Abstract: In Uzbekistan, snow leopard (Uncia uncia Schreber, 1776) is met in the mountain ridges of Tien Shan (Karjantau, Ugam, Pskem, Chatkal, and possibly Kurama ridges) and Alay (Turkistan, Zaravshan, Gissar, and Baisuntau ridges). There are about 50 snow leopards there. They are observed to decrease in number for the reasons as follows: extensive use of alpine pastures, tourist activity and poaching. Irbis is under protection in the Chatkal, Zaamin, and Gissar nature reserves and Zaamin people's park. An additional measure to be taken to protect this species is to expand the area of the Chatkal nature reserve, to better fight against poaching activity and advocate snow leopard protection in mass media.