Abstract: Human population growth in the Mountain Badakhshan autonomous province will result in changes of wild life habitat. The first highland nature reserve (Muksu river basin) is proposed to be established within the habitat of Marco Polo sheep, Siberian ibex, Tien Shan brown bear, snow leopard, Himalayan and Tibetan snow-cock, bar-headed goose, bearded and Himalayan vultures. The Mountain Badakhshan nature reserve will serve as a reference for other highland landscapes of the USSR, a `fiduciary' of gene bank containing valuable endemic, rare, and endangered animal and plant species.