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	Author	Trepanier, L.A.; Cribb, A.E.; Spielberg, S.P.; Ray, K.
	Title	Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene			Type	Journal Article
	Year	1998	Publication	Pharmacogenetics	Abbreviated Journal
	Volume	8	Issue	2	Pages	169-179
	Keywords	Acetylation; Amino; Acid; Sequence; Animal; Arylamine; N-Acetyltransferase; metabolism; Base; Blotting; Southern; Carnivora; genetics; Cats; Cytosol; enzymology; Dna; Human; Isoenzymes; Liver; Molecular; Data; Polymerase; Chain; Reaction; Rabbits; Homology; Nucleic Acid; Substrate; Specificity; Support; U.S.Gov't; P.H.S.; browse; nucleic; us; government; 130
	Abstract	The purpose of this study was to determine the molecular basis for a relative deficiency in the cat of cytosolic arylamine N- acetyltransferase (NAT), an enzyme family that is important in the metabolism of xenobiotics and that normally consists of at least two related enzymes, NAT1 and NAT2. N-acetyltransferase in feline liver showed high affinity (mean Km = 2.1 microM) for p-aminobenzoic acid, an NAT1 selective substrate in humans and rabbits, but showed a very poor affinity (mean Km > 10 mM) for sulfamethazine, an NAT2 selective substrate in humans and rabbits. Immunoreactive N-acetyltransferase was detected in feline liver, bladder and colon using an NAT1-specific antipeptide antibody, but was not detected in any tissues using an NAT2- specific antibody. Southern blot analysis of genomic DNA demonstrated a single band in domestic cats using each of six restriction digests; single bands were also found on Southern blot analysis of six wild felids. The deduced amino acid sequence of the central portion of feline N-acetyltransferase, obtained by polymerase chain reaction amplification in both domestic cats and seven wild felids (lion, tiger, lynx, snow leopard, bobcat, Asian leopard cat and cheetah), contained three residues, Phe125, Arg127, and Tyr129, which determine NAT1-like substrate specificity in humans. These results support the conclusion that cytosolic arylamine N-acetylation activity is low in the cat because of the presence of a single N-acetyltransferase that has substrate specificity, immunogenicity and sequence characteristics similar to human NAT1, and that the unusual presence of only a single N- acetyltransferase gene appears to be a family wide trait shared by other felids.
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	ISSN	0960-314x	ISBN		Medium
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	Notes	Document Type: eng			Approved	no
	Call Number	SLN @ rana @ 345			Serial	968
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	Author	Jackson, R., Ahlborn, G.G.
	Title	Appendix: Snow leopard managment recommendations provided to HMG in: Himalayan Snow Leopard Project: Final Progress Report, Phase I. Report: 1-7. Himalayan			Type	Report
	Year	1986	Publication		Abbreviated Journal
	Volume		Issue		Pages	1-7
	Keywords	action plan, CCT, conservation, Himalaya, human wildlife conflict, hunting, livestock, local participation, local people, management/protected
	Abstract	Preliminary recommendations for the management of snow leopard and its prey are provided for the Langu Valley segment of the Shey-Pkoksundo National Park. Park-wide and country-wide conservation options and management recommendations await results of the surveys scheduled for 1987. The following management objectives are formulated: 1) Protection and ultimate restoration of all natural communities within the area 2) Special protection measures for snow leopard and musk deer (strict control of hunting and livestock grazing) 3) Secure natural resources around local villages 4) Respect traditional rights of villagers, while controlling high impact human activities 5) Secure cooperation of local people. These objectives are refined and recommendations for concrete conservation actions are made. Notes: document is a part of the Himalayan Snow Leopard Project: Final Progress Report, Phase I
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	Notes				Approved	no
	Call Number	SLN @ rana @			Serial	1119
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	Author	Wolf, M.; Ale, S.
	Title	*Signs at the Top: Habitat Features Influencing Snow Leopard Uncia Uncia* Activity in Sagarmatha National Park, Nepal**			Type	Journal Article
	Year	2009	Publication	Journal of Mammalogy	Abbreviated Journal
	Volume	90	Issue	3	Pages	604-611
	Keywords	activity patterns,human activity,Nepal,predator-prey,sign data,Uncia uncia
	Abstract	We used logistic regression to examine factors that affected the spatial distribution of sign (scrapes, feces, footprints, spray or scent marks, and rubbing sites) in a newly reestablished population of snow leopards (Uncia uncia) in Sagarmatha (Mount Everest) National Park, Nepal. Our results indicate that terrain and human activity were the most important factors determining the spatial distribution of leopard activity, whereas presence of their major prey species (Himalayan tahr [Hemitragus jemlahicus]) had only a moderate effect. This suggests that localities at which these animals are active represent a trade-off between suitable habitat and avoidance of potential risk from anthropogenic origins. However, the influence of prey presence was likely underestimated because of the methodology used, and likely weighed in the trade-off as well.
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	Notes	Department of Biological Sciences (M/C 066), University of Illinois at Chicago, 845 West Taylor Street, 3352 SES, Chicago, IL 60607-7060, USA			Approved	no
	Call Number	SLN @ rana @ 1026			Serial	1027
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	Author	De Groot, H.; Van Swieten, P.; Aalberse, R.C.
	Title	Evidence for a Fel d I-like molecule in the “big cats” (Felidae species)			Type	Journal Article
	Year	1990	Publication	J Allergy Clin Immunol	Abbreviated Journal
	Volume	86	Issue	1	Pages	107-116
	Keywords	Adolescence; Adult; Allergens; immunology; Animal; Antibodies; Monoclonal; diagnostic; use; Antibody; Specificity; Carnivora; Cats; Comparative; study; Cross; Reactions; Hair; Histamine; Release; Human; IgE; analysis; IgG; Middle; Age; Radioallergosorbent; Test; methods; Support; Non-U.S.Gov't; browse; us; government; gov't; 240
	Abstract	In this study, we investigated the cross-reactivity pattern of IgE and IgG4 antibodies to the major feline allergen, Fel d I. We studied the IgE and IgG4 response of 11 cat-allergic patients against Fel d I-like structures in eight members of the Felidae family: ocelot, puma, serval, siberian tiger, lion, jaguar, snow leopard, and caracal. Hair from these “big cats” was collected, extracted, and used in a RAST system and histamine-release test. By means of a RAST-inhibition assay with affinity-purified Fel d I from cat dander, it was established that, in the Felidae species, a Fel d I equivalent is present that reacts with IgE and IgG4 antibodies. We found that all patients had cross-reacting IgE antibodies to seven of the Felidae tested; no IgE antibodies reactive with the caracal were found. Eight of 10 patients with IgG4 antibodies directed to cat dander also had IgG4 antibodies directed to several Felidae species, including the caracal. However, the correlation between the IgE and the IgG4 antibody specificity was low, indicating that, in the case of Fel d I IgE and IgG4, antibodies do not necessarily have the same specificity.
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	ISSN	0091-6749	ISBN		Medium
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	Notes	Document Type: eng			Approved	no
	Call Number	SLN @ rana @ 157			Serial	233
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	Author	Berenstein, F.
	Title	The snow leopard. Fusion in an Elaborated Delusional Fantasy			Type	Journal Article
	Year	1984	Publication	Am J Psychoanal	Abbreviated Journal
	Volume	44	Issue	4	Pages	377-397
	Keywords	Adolescence; Case; Report; Countertransference; Psychology; Divorce; Fantasy; Gender; Identity; Human; Male; Parent-Child; Relations; Professional-Patient; Psychoanalytic Interpretation; Psychoanalytic; therapy; Psychosexual; development; Transference; parent; child; professional; patient; interpretation; browse; 340
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	ISSN	0002-9548	ISBN		Medium
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	Notes	Document Type: eng			Approved	no
	Call Number	SLN @ rana @ 68			Serial	130
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	Author	Mishra, C.; Fitzherbert, A.
	Title	War and wildlife: a post-conflict assessment of Afghanistan's Wakhan Corridor			Type	Journal Article
	Year	2004	Publication	Oryx	Abbreviated Journal
	Volume	38	Issue	1	Pages	102-105
	Keywords	Afghanistan; fur trade; human-wildlife conflict; hunting; Lynx; marco polo sheep; snow leopard; Wakhan; wolf; 5270
	Abstract	Prior to the last two decades of conflict, Afghanistan's Wakhan Corridor was considered an important area for conservation of the wildlife of high altitudes. We conducted an assessment of the status of large mammals in Wakhan after 22 years of conflict, and also made a preliminary assessment of wildlife trade in the markets of Kabul, Faizabad and Ishkashem. The survey confirmed the continued occurrence of at least eight species of large mammals in Wakhan, of which the snow leopard Uncia uncia and Marco Polo sheep Ovis ammon are globally threatened. We found evidence of human-wildlife conflict in Wakhan due to livestock depredation by snow leopard and wolf Canis lupus. Large mammals are hunted for meat, sport, fur, and in retaliation against livestock depredation. The fur trade in Kabul is a threat to the snow leopard, wolf, lynx Lynx lynx and common leopard Panthera pardus.
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	Notes	Document Type: English			Approved	no
	Call Number	SLN @ rana @ 512			Serial	694
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	Author	Rovero, F., Augugliaro, C., Havmoller, R. W., Groff, C., Zimmerman, F., Oberosler, V., Tenan, S.
	Title	Co-occurrence of snow leopard Panthera uncia, Siberian ibex Capra sibirica and livestock: potential relationships and effects			Type	Journal Article
	Year	2018	Publication	Oryx	Abbreviated Journal
	Volume		Issue		Pages	1-7
	Keywords	Altai mountains, camera trapping, human� wildlife conflict, Mongolia, occupancy, occurrence interactions, Siberian ibex, snow leopard
	Abstract	Understanding the impact of livestock on native wildlife is of increasing conservation relevance. For the Vulnerable snow leopard Panthera uncia, wild prey reduction, intensifying human�wildlife conflicts and retaliatory killings are severe threats potentially exacerbated by the presence of livestock. Elucidating patterns of co-occurrence of snow leopards, wild ungulate prey, and livestock, can be used to assess the compatibility of pastoralism with conservation. We used camera trapping to study the interactions of livestock, Siberian ibex Capra sibirica and snow leopards in a national park in the Altai mountains, Mongolia. We obtained  detections of wild mammals and  of domestic ungulates, dogs and humans. Snow leopards and Siberian ibex were recorded  and  times, respectively. Co-occurrence modelling showed that livestock had a higher estimated occupancy (.) than ibex, whose occupancy was lower in the presence of livestock (.) than in its absence (.�. depending on scenarios modelled). Snow leopard occupancy did not appear to be affected by the presence of livestock or ibex but the robustness of such inference was limited by uncertainty around the estimates. Although our sampling at presumed snow leopard passing sites may have led to fewer ibex detections, results indicate that livestock may displace wild ungulates, but may not directly affect the occurrence of snow leopards. Snow leopards could still be threatened by livestock, as overstocking can trigger human�carnivore conflicts and hamper the conservation of large carnivores. Further research is needed to assess the generality and strength of our results.
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	Notes				Approved	no
	Call Number	SLN @ rakhee @			Serial	1465
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	Author	Roth, T.L.; Armstrong, D.L.; Barrie, M.T.; Wildt, D.E.
	Title	Seasonal effects on ovarian responsiveness to exogenous gonadotrophins and successful artificial insemination in the snow leopard (Uncia uncia)			Type	Journal Article
	Year	1997	Publication	Reprod Fertil Dev	Abbreviated Journal
	Volume	9	Issue	3	Pages	285-295
	Keywords	Animal; Carnivora; anatomy; histology; Blood; physiology; Estradiol; Female; Gonadotropins; administration; dosage; pharmacology; Chorionic; Equine; Human; Insemination; artificial; methods; veterinary; Laparoscopy; Male; Oocytes; cytology; Ovary; drug; effects; Ovulation; Induction; Pregnancy; Progesterone; Seasons; Support; Non-U.S.Gov't; browse; non; us; gov't; government; 400
	Abstract	Ovaries of the seasonally-breeding snow leopard (Uncia uncia) were examined to determine whether they were responsive to exogenous gonadotrophins throughout the year. The potential of laparoscopic artificial insemination (AI) also was assessed for producing offspring. During the non-breeding, pre-breeding, breeding and post-breeding seasons, females (n = 20) were treated with a standardized, dual- hormone regimen given intramuscularly (600 I.U. of equine chorionic gonadotrophin followed 80-84 h later with 300 I.U. of human chorionic gonadotrophin (hCG)). Laparoscopy was performed 45-50 h after administration of hCG, and all ovarian structures were described. Females with fresh corpora lutea (CL) were inseminated, and anovulatory females were subjected to follicular aspiration to examine oocyte quality. Snow leopards responded to exogenous gonadotrophins throughout the year. Mean number of total ovarian structures (distinct follicles mature in appearance plus CL) did not differ (P > or = 0.05) with season, but the proportion of CL: total ovarian structures was greater (P < 0.01) for the breeding season compared with all other seasons. The proportion of females ovulating was greater (P < 0.05) during the breeding and post-breeding seasons than during the pre-breeding and non- breeding seasons respectively. No Grade-1 quality oocytes were recovered from follicles of anovulatory females. Serum concentrations of oestradiol-17 beta appeared elevated in all females, and neither oestradiol-17 beta concentrations nor progesterone concentrations differed (P > or = 0.05) among seasons. Of 15 females artificially inseminated, the only one that was inseminated in the non-breeding season became pregnant and delivered a single cub. This is the first successful pregnancy resulting from AI in this endangered species.
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	Series Volume		Series Issue		Edition
	ISSN	1031-3613	ISBN		Medium
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	Notes	Document Type: eng			Approved	no
	Call Number	SLN @ rana @ 325			Serial	830
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	Author	Filla, M., Lama, R. P., Filla, T., Heurich, M., Balkenhol, N., Waltert, M., Khorozyan, I.
	Title	Patterns of livestock depredation by snow leopards and effects of intervention strategies: lessons from the Nepalese Himalaya			Type	Journal Article
	Year	2022	Publication	Wildlife Research	Abbreviated Journal
	Volume		Issue		Pages
	Keywords	Annapurna, co-existence, conservation biology, highland communities, human–wildlife conflict, large carnivore, livestock depredation, Panthera uncia, prey selection, snow leopard.
	Abstract	Context: Large carnivores are increasingly threatened by anthropogenic activities, and their protection is among the main goals of biodiversity conservation. The snow leopard (Panthera uncia) inhabits high-mountain landscapes where livestock depredation drives it into conflicts with local people and poses an obstacle for its conservation. Aims: The aim of this study was to identify the livestock groups most vulnerable to depredation, target them in implementation of practical interventions, and assess the effectiveness of intervention strategies for conflict mitigation. We present a novel attempt to evaluate intervention strategies for particularly vulnerable species, age groups, time, and seasons. Methods: In 2020, we conducted questionnaire surveys in two regions of the Annapurna Conservation Area, Nepal (Manang, n = 146 respondents and Upper Mustang, n = 183). We applied sample comparison testing, Jacobs’ selectivity index, and generalised linear models (GLMs) to assess rates and spatio-temporal heterogeneity of depredation, reveal vulnerable livestock groups, analyse potential effects of applied intervention strategies, and identify husbandry factors relevant to depredation. Key results: Snow leopard predation was a major cause of livestock mortality in both regions (25.4–39.8%), resulting in an estimated annual loss of 3.2–3.6% of all livestock. The main intervention strategies (e.g. corrals during night-time and herding during daytime) were applied inconsistently and not associated with decreases in reported livestock losses. In contrast, we found some evidence that dogs, deterrents (light, music playing, flapping tape, and dung burning), and the use of multiple interventions were associated with a reduction in reported night-time depredation of yaks. Conclusions and implications: We suggest conducting controlled randomised experiments for quantitative assessment of the effectiveness of dogs, deterrents, and the use of multiple interventions, and widely applying the most effective ones in local communities. This would benefit the long-term co-existence of snow leopards and humans in the Annapurna region and beyond.
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	Notes				Approved	no
	Call Number	SLN @ rakhee @			Serial	1684
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	Author	Lu, Q., Xiao, L., Cheng, C., Lu, Z., Zhao, J., Yao, M.
	Title	Snow Leopard Dietary Preferences and Livestock Predation Revealed by Fecal DNA Metabarcoding: No Evidence for Apparent Competition Between Wild and Domestic Prey			Type	Journal Article
	Year	2021	Publication	Frontiers in Ecology and Evolution	Abbreviated Journal
	Volume	9	Issue	783546	Pages	1 - 14
	Keywords	apparent mutualism, blue sheep, feeding habits, molecular dietary analysis, human-carnivore conflict, prey selection, Sanjiangyuan
	Abstract	Accurate assessments of the patterns and drivers of livestock depredation by wild carnivores are vital for designing effective mitigation strategies to reduce human-wildlife conflict. Snow leopard’s (Panthera uncia) range extensively overlaps pastoralist land- use and livestock predation there is widely reported, but the ecological determinants of livestock consumption by snow leopards remain obscure. We investigated snow leopard dietary habits at seven sites across the Sanjiangyuan region of the Qinghai– Tibetan Plateau (QTP), an area central to the species’ global range. Snow leopard abundance, wild prey composition, and livestock density varied among those sites, thus allowing us to test the effects of various factors on snow leopard diet and livestock predation. Using DNA metabarcoding, we obtained highly resolved dietary data from 351 genetically verified snow leopard fecal samples. We then analyzed the prey preferences of snow leopards and examined ecological factors related to their livestock consumption. Across the sites, snow leopard prey was composed mainly of wild ungulates (mean = 81.5% of dietary sequences), particularly bharal (Pseudois nayaur), and supplemented with livestock (7.62%) and smaller mammals (marmots, pikas, mice; 10.7%). Snow leopards showed a strong preference for bharal, relative to livestock, based on their densities. Interestingly, both proportional and total livestock consumption by snow leopards increased linearly with local livestock biomass, but not with livestock density. That, together with a slight negative relationship with bharal density, supports apparent facilitation between wild and domestic prey. We also found a significant positive correlation between population densities of snow leopard and bharal, yet those densities showed slight negative relationships with livestock density. Our results highlight the importance of sufficient wild ungulate abundance to the conservation of viable snow leopard populations. Additionally, livestock protection is critically needed to reduce losses to snow leopard depredation, especially where local livestock abundances are high.
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	Notes				Approved	no
	Call Number	SLN @ rakhee @			Serial	1675
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