Abstract: The recent development of potent and specifica lphar-adrenoceptoar gonistsa nd antagonists has enhanced their use in nondomestic animal immobilization and reversal. Medetomidine, a new potent alphar-agonist, in combination with the dissociative anesthetic ketamine, has been used to immobilize a variety of nondomestic mammals. Medetomidine alone induces sedation in a dose-dependent way, and complete immobilization has been achieved with high doses in semidomesticated reindeer (Rangifer tarandus) and blue foxes (Alopex lagopus). Howbver, we feel that ketamine should be added to the immobilization mixture to ensure complete immobilization and operator safety. In ketamine combinations, medetomidine doses are usually 60-100 pg/kg. The required ketamine doses are remarkably low:0.8-1.6 mglkg in most ruminants,2.5-3.0 mgUgin felids,u rsids,a nd canids,a nd 5.G-8.0m glkgi n primates,w olverines(Gulog ulo),ando therm uitelids. Clinically, the resulting immobilization is characterized by a smooth onset, good to excellent myorelaxation, and areflexia at higher doses. Determinations of hematologic, serum biochemicil, arterial blood gas,a nd acid-bases tatusp arametersi ndicate that the immobilization is physiologically sound. We have had no fatalities attributable to the immobilization mixture ( I ,240 immobilizations). The alphar-adrenoceptora ntagonist,a tipamezole,i s highly efective in reversingt he immobilization induced by medetomidine, medetomidine-ketamine combinations, or xylazine. In ruminants, the medetomidine-ketamine-induced immobilization can be rapidly and persistently reversed by administering 100-l 50 1rg/kg of alipamezole i.v. and the rest s.c., adjusting the total atipamezole dose to an atipamezole: medetomidine ratio of approximately 4-5 (w/w). Becauseth e required ketamine doses are relatively high in carnivores, we prefer to use a lower atipamezole dose (totil atipamezoie: medetomidine ratio approximately 2-3 w/w) and to administer it i.m. or s.c. Using thii regimen, reversals are calm and animals show minimal “residual ketamine effect.” Because atipamezole is a competitive antagonist, its dose should be reduced if it is administered late in the immobilization period when a large part of medetomidine has been endogenously metabolized. Xylazine-induced immobilization is rapidly reversed by I mg of atipamezole for every 8-12 mg of xylazine used.

Abstract: Snow leopard is an endangered species. Its number is steadily decreasing. In the USSR, snow leopard is distributed in the mountains of Central Asia: Pamir, Tien Shan, Djungar Ala-Tau, Tarbagatai, Saur. It is also met at altitudes ranging from 1,800 3,500 m above sea level. A total number of snow leopard in the USSR does not exceed 1,000 animals; according to other data 2,000 animals. A decreasing number of snow leopard and its habitat shrinkage is directly related to human's pursuing snow leopards (in the USSR snow leopard was for a long time being considered as a species causing damage to livestock so authorities gave premiums for catching/shooting snow leopards) and reduction of ungulate population. Snow leopards are now protected in mountain nature reserves of the USSR: Chatkal, Aksu-Djabagly, Ramit, Besh-Aral, Sary-Chelek, and Alma-Ata.

Abstract: Many years' data connected with the distribution and number of endangered species of animals as dhole (Cuon alpinus Pall), striped hyena (Hyaena hyaena L.), snow leopard (Uncia uncia Shreb.) and birds of Tajikistan are given. Area of snow leopard includes the most of mountain ridges in this country. The total number is evaluated about 160-200 individuals. The record quantity of legal harvested skins of snow leopard is 64 in 1946.

Abstract: It provides description of appearance, distribution, behavioral patterns, and use of snow leopard in the USSR. The predator inhabits the mountains of Central Asia, east of the Amudarya river, along the ridges of Djungar Ala-Tau and Tarbagatai, South Altai, West and East Sayans. Its main food is ungulates, though it also preys on snow-cocks, marmots, small birds, and rodents. Sometimes attacks sheep. It has no enemy other than wolf; its diseases are not studied. Snow leopard is not dangerous for man. The fur-skin is used for making rugs and fur. Less than 1,000 animals are hunted globally. Before 1960, in the USSR less than 120 skins were annually purchased. Its total population is several thousand animals.