| Records |
| Author |
Trepanier, L.A.; Cribb, A.E.; Spielberg, S.P.; Ray, K. |
| Title |
Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene |
Type |
Journal Article |
Year  |
1998 |
Publication |
Pharmacogenetics |
Abbreviated Journal |
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| Volume |
8 |
Issue |
2 |
Pages |
169-179 |
| Keywords |
Acetylation; Amino; Acid; Sequence; Animal; Arylamine; N-Acetyltransferase; metabolism; Base; Blotting; Southern; Carnivora; genetics; Cats; Cytosol; enzymology; Dna; Human; Isoenzymes; Liver; Molecular; Data; Polymerase; Chain; Reaction; Rabbits; Homology; Nucleic Acid; Substrate; Specificity; Support; U.S.Gov't; P.H.S.; browse; nucleic; us; government; 130 |
| Abstract |
The purpose of this study was to determine the molecular basis for a relative deficiency in the cat of cytosolic arylamine N- acetyltransferase (NAT), an enzyme family that is important in the metabolism of xenobiotics and that normally consists of at least two related enzymes, NAT1 and NAT2. N-acetyltransferase in feline liver showed high affinity (mean Km = 2.1 microM) for p-aminobenzoic acid, an NAT1 selective substrate in humans and rabbits, but showed a very poor affinity (mean Km > 10 mM) for sulfamethazine, an NAT2 selective substrate in humans and rabbits. Immunoreactive N-acetyltransferase was detected in feline liver, bladder and colon using an NAT1-specific antipeptide antibody, but was not detected in any tissues using an NAT2- specific antibody. Southern blot analysis of genomic DNA demonstrated a single band in domestic cats using each of six restriction digests; single bands were also found on Southern blot analysis of six wild felids. The deduced amino acid sequence of the central portion of feline N-acetyltransferase, obtained by polymerase chain reaction amplification in both domestic cats and seven wild felids (lion, tiger, lynx, snow leopard, bobcat, Asian leopard cat and cheetah), contained three residues, Phe125, Arg127, and Tyr129, which determine NAT1-like substrate specificity in humans. These results support the conclusion that cytosolic arylamine N-acetylation activity is low in the cat because of the presence of a single N-acetyltransferase that has substrate specificity, immunogenicity and sequence characteristics similar to human NAT1, and that the unusual presence of only a single N- acetyltransferase gene appears to be a family wide trait shared by other felids. |
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0960-314x |
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Document Type: eng |
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no |
| Call Number |
SLN @ rana @ 345 |
Serial |
968 |
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| Author |
Wasser, S. |
| Title |
Snow Leopard Genetics: New Techniques |
Type |
Miscellaneous |
| Year |
1998 |
Publication |
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Abbreviated Journal |
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| Volume |
xvi |
Issue |
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Pages |
8 |
| Keywords |
genetics; medicine; veterinary; Dna; feces; scat; browse; 4500 |
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Islt |
Place of Publication |
Seattle |
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Full Text at URLJournal Title: Snow Line |
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no |
| Call Number |
SLN @ rana @ 438 |
Serial |
1009 |
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| Author |
Woodroffe, R.; Ginsberg, J.R. |
| Title |
Edge effects and the extinction of populations inside protected areas |
Type |
Journal Article |
| Year |
1998 |
Publication |
Science Washington D.C. |
Abbreviated Journal |
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| Volume |
280 |
Issue |
5372 |
Pages |
2126-2128 |
| Keywords |
edge-effects; extinction; human-animal-conflict; mortality; population-size; protected-areas; browse; edge effects; Human; Animal; conflict; population; protected; area; 590 |
| Abstract |
Theory predicts that small populations may be driven to extinction by random fluctuations in demography and loss of genetic diversity through drift. However, population size is a poor predictor of extinction in large carnivores inhabiting protected areas. Conflict with people on reserve borders is the major cause of mortality in such populations, so that border areas represent population sinks. The species most likely to disappear from small reserves are those that range widely-and are therefore most exposed to threats on reserve borders-irrespective of population size. Conservation efforts that combat only stochastic processes are therefore unlikely to avert extinction. |
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Document Type: English |
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no |
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SLN @ rana @ 351 |
Serial |
1028 |
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| Author |
Xu, H.F.; Zhang, E.D.; Song, H.G. |
| Title |
Wildlife conservation and management principles and techniques |
Type |
Miscellaneous |
| Year |
1998 |
Publication |
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Pages |
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5620 |
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East China Normal University Press |
Place of Publication |
Shanghai |
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no |
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SLN @ rana @ 546 |
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1040 |
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| Author |
Yang, Q.S.; Feng, Z.J. |
| Title |
Snow Leopards Uncia Uncia |
Type |
Book Chapter |
| Year |
1998 |
Publication |
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Abbreviated Journal |
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Issue |
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Pages |
132-135 |
| Keywords |
5640 |
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Science Press |
Place of Publication |
Beijing |
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Medium Designator: China Red Data Book of Endangered Animals: Mammalia |
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SLN @ rana @ 548 |
Serial |
1051 |
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| Author |
Yuan, G.Y. |
| Title |
Natural environmental protection and nature reserves in Xinjiang |
Type |
Miscellaneous |
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1998 |
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5660 |
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Science, Technology and Hygiene Publishing House of Xinjiang, Urumqi |
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Xinjiang, Urumqi |
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no |
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SLN @ rana @ 550 |
Serial |
1065 |
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| Author |
International Snow Leopard Trust |
| Title |
Snow Line |
Type |
Miscellaneous |
| Year |
1998 |
Publication |
Snow Line |
Abbreviated Journal |
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| Volume |
xvi |
Issue |
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Pages |
1-12 |
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Newsletter of International Snow Leopard Trust |
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SLN @ rana @ |
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1156 |
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| Author |
International Snow Leopard Trust |
| Title |
ISLT Hires Snow Leopard Conservationist in India |
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Magazine Article |
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1998 |
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1357 |
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Planning Wildlife Conservation in Leh and Kargil Districts of Ladakh, Jammu and Kashmir |
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Establising Snow Leopard Information Management System (SLIMS) at WII Phase 1 – Trans Himalaya |
Type |
Report |
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1999 |
Publication |
Wildlife Institute of India |
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no |
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SLN @ rakhee @ |
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1495 |
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| Author |
Allen, P. |
| Title |
WWF Progress Report: Irbis Enterprises Snow Leopard Conservation Incentive Project |
Type |
Miscellaneous |
| Year |
1999 |
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| Keywords |
irbis; conservation; herders; livestock; economics; Mongolia; gobi; poaching; community-development; development; browse; community; 4100 |
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English |
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Location: Uvs Aimag (Turgen and Tsagaan Shuvuut Strictly Protected Areas)Gobi Altai Aimag (Great Gobi Strictly Protected Area) |
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no |
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SLN @ rana @ 355 |
Serial |
65 |
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