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Author Kazensky, C.A.; Munson, L.; Seal, U.S.   
  Title The effects of melengestrol acetate on the ovaries of captive wild felids Type Journal Article
  Year 1998 Publication Journal-of-Zoo-and-Wildlife-Medicine Abbreviated Journal  
  Volume (up) 29 Issue 1 Pages 1-5  
  Keywords Mga; zoo; felids; contraception; Melengestrol-acetate; ovaries; snow-leopard; Panthera-uncia; snow leopard; browse; uncia; panthera; melengestrol; acetate; 1260; effects; study; ovarian; Ovary; captive; wild; wild felid; Wild-Felid; species; Follicle; Cats; cat; recent; Ovulation; doses; Dose; action; Progestin; Disease; veterinary  
  Abstract Melengestrol acetate (MGA) is the most widely used contraceptive in zoo felids, but the mechanism of contraception and the pathologic effects have not been investigated. For this study, the effects of MGA on folliculogenesis were assessed, and the association of MGA with ovarian lesions was evaluated. Comparisons were made among the histopathologic findings in the ovaries from 88 captive wild felids (representing 15 species) divided into three groups: 37 currently contracepted with MGA, eight previously exposed to MGA, and 43 never contracepted. Ninety-one percent of the felids evaluated had tertiary follicles, and no differences were noted between contracepted and uncontracepted cats. Some MGA-contracepted cats also had corpora lutea indicating recent ovulation. These results indicate that folliculogenesis is not suppressed by current doses of MGA and ovulation occurred in some cats. Therefore, the contraceptive actions of MGA do not occur by suppressing folliculogenesis, and MGA-contracepted felids likely have endogenous estrogens that may confound progestin effects on the uterus. Cystic rete ovarii was the most common pathologic finding, but they were not more prevalent in MGA-contracepted cats. These findings indicate that MGA is not associated with ovarian disease, including ovarian cancer, in contrast to the uterine lesions noted in MGA-treated cats.  
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  Notes Document Type: English. Affiliation: Taylor Veterinary Hospital, Turlock , California 95382, USA Approved no  
  Call Number SLN @ rana @ 348 Serial 527  
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Author Thorel, M.F.; Karoui, C.; Varnerot, A.; Fleury, C.; Vincent, V. url 
  Title Isolation of Mycobacterium bovis from baboons, leopards and a sea-lion Type Journal Article
  Year 1998 Publication Vet Res Abbreviated Journal  
  Volume (up) 29 Issue 2 Pages 207-212  
  Keywords Animal; Animals; zoo; Carnivora; microbiology; Case; Report; Cattle; Dna; Fingerprinting; Transposable; Elements; Disease; Outbreaks; veterinary; France; Genome; Bacterial; Germany; Male; Monkey; Diseases; diagnosis; epidemiology; Mycobacterium; Infections; bovis; classification; isolation; purification; Papio; Seals; browse; 440  
  Abstract This study reports on two series of cases of Mycobacterium bovis infection in zoo animals. The first was in a captive population of baboons (Papio hamadryas) and the second in a mixed group of wild mammals, including four leopards (Panthera uncia and Panthera pardus) and a sea-lion (Otaria byrona). The isolation and identification of strains of M. bovis confirmed the presence of M. bovis infections in both zoos. The epidemiological study using genetic markers such as the IS6110-based DNA fingerprinting system made it possible to differentiate between M. bovis strains. The M. bovis strains isolated from baboons were shown to contain a single IS6110 copy, as usually do cattle isolates, whereas the M. bovis strains isolated from the other exotic animals presented multiple copies. This finding suggests that the origin of the contamination for the baboons in zoo A could be related to cattle. The origin of the contamination for the leopards and sea-lion in zoo B is more difficult to determine. In conclusion, the authors suggest some recommendations for avoiding outbreaks of tuberculosis infections in zoos.  
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  ISSN 0928-4249 ISBN Medium  
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  Notes Document Type: eng Approved no  
  Call Number SLN @ rana @ 346 Serial 966  
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Author Kolmstetter, C.; Munson, L.; Ramsay, E.C. url 
  Title Degenerative spinal disease in large felids Type Journal Article
  Year 2000 Publication J Zoo Wildl Med Abbreviated Journal  
  Volume (up) 31 Issue 1 Pages 15-19  
  Keywords Age-Factors; Animal; Animals; zoo; Autopsy; veterinary; Carnivora; Female; Lions; Male; Age; factor; browse; 110  
  Abstract Degenerative spinal disorders, including intervertebral disc disease and spondylosis, seldom occur in domestic cats. In contrast, a retrospective study of 13 lions (Panthera leo), 16 tigers (Panthera tigris), 4 leopards (Panthera pardis), 1 snow leopard (Panthera uncia), and 3 jaguars (Panthera onca) from the Knoxville Zoo that died or were euthanatized from 1976 to 1996 indicated that degenerative spinal disease is an important problem in large nondomestic felids. The medical record, radiographic data, and the necropsy report of each animal were examined for evidence of intervertebral disc disease or spondylosis. Eight (three lions, four tigers, and one leopard) animals were diagnosed with degenerative spinal disease. Clinical signs included progressively decreased activity, moderate to severe rear limb muscle atrophy, chronic intermittent rear limb paresis, and ataxia. The age at onset of clinical signs was 10-19 yr (median = 18 yr). Radiographic evaluation of the spinal column was useful in assessing the severity of spinal lesions, and results were correlated with necropsy findings. Lesions were frequently multifocal, included intervertebral disc mineralization or herniation with collapsed intervertebral disc spaces, and were most common in the lumbar area but also involved cervical and thoracic vertebrae. Marked spondylosis was present in the cats with intervertebral disc disease, presumably subsequent to vertebral instability. Six of the animals' spinal cords were examined histologically, and five had acute or chronic damage to the spinal cord secondary to disc protrusion. Spinal disease should be suspected in geriatric large felids with decreased appetite or activity. Radiographic evaluation of the spinal column is the most useful method to assess the type and severity of spinal lesions.  
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  ISSN 1042-7260 ISBN Medium  
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  Notes Document Type: eng Approved no  
  Call Number SLN @ rana @ 384 Serial 545  
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Author Pfeil, A.; Lucker, H.; Pfeil, I.   
  Title Leiomyoma in the urinary bladder of a female snow leopard (Uncia uncia, Schreber, 1776) Type Journal Article
  Year 2004 Publication Tier„rztliche Praxis Kleintiere Abbreviated Journal  
  Volume (up) 32 Issue 1 Pages 40-44  
  Keywords Bladder; captive; diagnostic; Female; german; leopard; origin; snow-leopard; snow-leopards; snow leopard; snow leopards; surgery; therapy; uncia; Uncia-uncia; Uncia uncia; urinary; veterinary; zoo  
  Abstract Summary

A leiomyoma of the urinary bladder in a 14-year-old female snow leopard exhibiting bloody vaginal discharge was removed by partial cystectomy. Gravel (struvite) was found in the urine of the inflammatory bladder. Additionally ovario-hysterectomy was performed. Histological findings showed a glandular-cystic hyperplasia. Tumors of the bladder are very rare in cats. Specifically the benign tumors of the bladder very often have no clinical relevance and rarely result in bladder dysfunction. Therefore they might remain undiagnosed in many cases, particularly since the diagnostic procedure in big cats is very extensive. Leiomyoma of the bladder in snow leopards have not been described yet. The present paper describes the surgery performed, the succeeding therapy, the struvit prophylaxis, and discusses the aetiology of the leiomyoma's origin on the basis of current literature. Zusammenfassung

Bei einer 14-j„hrigen Schneeleopardin mit blutigem Vaginalausfluss wurde ein Leiomyom der Blase durch partielle Zystektomie entfernt. Im Urin und in der entzndeten Blase konnte Grieá (Struvit) nachgewiesen werden. Gleichzeitig wurde eine Ovariohysterektomie durchgefhrt. Der histologische Befund ergab eine glandul„r-zystische Hyperplasie des Endometriums. Tumoren der Harnblase sind bei Katzen sehr selten. Vor allem benigne Blasentumoren haben oft keine klinische Relevanz und fhren selten zu Blasenfunktionsst”rungen. Es ist daher m”glich, dass sie insbesondere bei Groákatzen wegen der aufwendigen Diagnostik bersehen werden. Leiomyome in der Blase sind beim Schneeleoparden bisher nicht beschrieben. In diesem Artikel werden die durchgefhrte Operation, die folgende Therapie und Struvitprophylaxe beschrieben sowie m”gliche Žtiologien der Entstehung des Leiomyoms anhand der Literatur diskutiert.
 
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  Notes In German. Title: Leiomyom in der Blase bei einem weiblichen Schneeleoparden (Uncia uncia, Schreber, 1776). Aus dem Zoologischen Garten Dresden (Direktor: Dr. H. Lcker) und der Tier„rztlichen Klinik Dr. I. Pfeil, Dresden. Approved no  
  Call Number SLN @ rana @ 1055 Serial 772  
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Author Wharton, D.; Mainka, S.A. url 
  Title Management and husbandry of the snow leopard Uncia uncia Type Journal Article
  Year 1997 Publication International Zoo Yearbook Abbreviated Journal  
  Volume (up) 35 Issue Pages 139-147  
  Keywords breeding; captive-management; diet; enclosures; housing; husbandry; nutrition; veterinary-care; zoo; browse; veterinary; care; captive; management; 1290  
  Abstract The international studbook for the Snow leopard Uncia uncia was established in 1976. The species has been the focus of intensive captive management and as at 1 January 1992, 541 animals were maintained at 160 collections. This paper gives an overview of the diet, housing, breeding and captive management of the species with specific reference to animals maintained in North American collections. A summary of veterinary care reported in the Snow leopard captive-management survey is also given.  
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  Notes Document Type: English Approved no  
  Call Number SLN @ rana @ 331 Serial 1018  
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Author Chandra, S.; Laughlin, D.C. url 
  Title Virus-like particles in cystic mammary adenoma of a snow leopard Type Journal Article
  Year 1975 Publication Cancer Res Abbreviated Journal  
  Volume (up) 35 Issue 11 Pt 1 Pages 3069-3074  
  Keywords Adenoma pathology veterinary; Animal; Animals; zoo; Carnivora; Cytoplasmic Granules; Endoplasmic Reticulum: ultrastructure; Inclusion Bodies; Mammae: pathology; Neoplasms: pathology: veterinary; neoplasms; pathology; mammae; inclusion; bodies; ultrastructure; reticulum; endoplasmic; granules; cytoplasmic; adenoma; veterinary; browse; 380  
  Abstract Virus-like particles were observed in the giant cells of a mammary adenoma of a snow leopard kept in captivity. Particles that measured 115 to 125 nm in diameter budded from the lamella of endoplasmic reticulum and were studded on their inner surfaces with dense granules (approximately 12 nm) that gave them their unique ultrastructural morphology. Such particles were not observed extracellularly. Type B or type C particles were not seen in the tumor tissue.  
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  ISSN 0008-5472 ISBN Medium  
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  Notes Document Type: eng Approved no  
  Call Number SLN @ rana @ 27 Serial 212  
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Author Sundberg, J.P.; Van Ranst, M.; Montali, R.; Homer, B.L.; Miller, W.H.; Rowland, P.H.; Scott, D.W.; England, J.J.; Dunstan, R.W.; Mikaelian, I.; Jenson, A.B. url 
  Title Feline papillomas and papillomaviruses Type Journal Article
  Year 2000 Publication Vet Pathol Abbreviated Journal  
  Volume (up) 37 Issue 1 Pages 1-10  
  Keywords Animal; Antibodies; Monoclonal; Carnivora; pathology; virology; Cats; Dna; Viral; chemistry; Epitope; Mapping; veterinary; Female; Immunohistochemistry; Lions; Male; Microscopy; Electron; Papilloma; Papillomavirus; Papovaviridae; Infections; skin; neoplasms; Tongue; browse; 120  
  Abstract Papillomaviruses (PVs) are highly species- and site-specific pathogens of stratified squamous epithelium. Although PV infections in the various Felidae are rarely reported, we identified productive infections in six cat species. PV-induced proliferative skin or mucous membrane lesions were confirmed by immunohistochemical screening for papillomavirus-specific capsid antigens. Seven monoclonal antibodies, each of which reacts with an immunodominant antigenic determinant of the bovine papillomavirus L1 gene product, revealed that feline PV capsid epitopes were conserved to various degrees. This battery of monoclonal antibodies established differential expression patterns among cutaneous and oral PVs of snow leopards and domestic cats, suggesting that they represent distinct viruses. Clinically, the lesions in all species and anatomic sites were locally extensive and frequently multiple. Histologically, the areas of epidermal hyperplasia were flat with a similarity to benign tumors induced by cutaneotropic, carcinogenic PVs in immunosuppressed human patients. Limited restriction endonuclease analyses of viral genomic DNA confirmed the variability among three viral genomes recovered from available frozen tissue. Because most previous PV isolates have been species specific, these studies suggest that at least eight different cat papillomaviruses infect the oral cavity (tentative designations: Asian lion, Panthera leo, P1PV; snow leopard, Panthera uncia, PuPV-1; bobcat, Felis rufus, FrPV; Florida panther, Felis concolor, FcPV; clouded leopard, Neofelis nebulosa, NnPV; and domestic cat, Felis domesticus, FdPV-2) or skin (domestic cat, F. domesticus, FdPV-1; and snow leopard, P. uncia, PuPV-2).  
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  ISSN 0300-9858 ISBN Medium  
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  Notes Document Type: eng Approved no  
  Call Number SLN @ rana @ 385 Serial 948  
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Author Roth, T.L.; Swanson, W.F.; Wildt, D.E. url 
  Title Snow leopard (Panthera unica) sperm longevity in vitro is not influenced by protein or energy source supplements but is affected by buffer source Type Journal Article
  Year 1995 Publication Theriogenology Abbreviated Journal  
  Volume (up) 43 Issue 1 Pages 309  
  Keywords genetics; Sperm; captivity; medical; medicine; veterinary; zoo; breeding; browse; 1400  
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  Notes Annual Conference of the International Embryo Transfer Society, Calgary, Alberta, Canada, January 8-10, 1995 Document Type: English Call Number: QP251 .T44 Approved no  
  Call Number SLN @ rana @ 280 Serial 829  
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Author Pollock, R.V.; Carmichael, L.E. url 
  Title Use of modified live feline panleukopenia virus vaccine to immunize dogs against canine parvovirus Type Journal Article
  Year 1983 Publication Am J Vet Res Abbreviated Journal  
  Volume (up) 44 Issue 2 Pages 169-175  
  Keywords Animal; Antibodies; Viral; biosynthesis; Dog; Diseases; microbiology; prevention; control; Dogs; Dose; Response; Relationship; Immunologic; Parvoviridae; immunology; Parvovirus; Feline; growth; development; Support; Non-U.S.Gov't; Vaccines; Attenuated; Virus; veterinary; Replication; browse; 350  
  Abstract Modified live feline panleukopenia virus (FPLV) vaccine protected dogs against canine parvovirus (CPV) infection. However, unlike the long- lived (greater than or equal to 20-month) immunity engendered by CPV infection, the response of dogs to living FPLV was variable. Doses of FPLV (snow leopard strain) in excess of 10(5.7) TCID50 were necessary for uniform immunization; smaller inocula resulted in decreased success rates. The duration of immunity, as measured by the persistence of hemagglutination-inhibiting antibody, was related to the magnitude of the initial response to vaccination; dogs with vigorous initial responses resisted oronasal CPV challenge exposure 6 months after vaccination, and hemagglutination-inhibiting antibodies persisted in such dogs for greater than 1 year. Limited replication of FPLV in dogs was demonstrated, but unlike CPV, the feline virus did not spread to contact dogs or cats. Adverse reactions were not associated with living FPLV vaccination, and FPLV did not interfere with simultaneous response to attenuated canine distemper virus.  
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  ISSN 0002-9645 ISBN Medium  
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  Notes Document Type: eng Approved no  
  Call Number SLN @ rana @ 69 Serial 784  
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Author Rieger, I.; Peters, G. url 
  Title Observations on the mating and vocal behavior of snow leopards (Uncia-uncia) in zoological garden Type Journal Article
  Year 1981 Publication Zeitschrift Fur Saugetierkunde International Journal of Mamamalian Biology Abbreviated Journal  
  Volume (up) 46 Issue 1 Pages 35-48  
  Keywords mating; breeding; vocalization; zoos; zoo; veterinary; behavior; browse; 1570  
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  Notes Publisher:GUSTAV FISCHER VERLAG, JENA Document Type: German Approved no  
  Call Number SLN @ rana @ 59 Serial 821  
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