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Author |
Trepanier, L.A.; Cribb, A.E.; Spielberg, S.P.; Ray, K. |
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Title |
Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene |
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Year |
1998 |
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Pharmacogenetics |
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8 |
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2 |
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169-179 |
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Keywords |
Acetylation; Amino; Acid; Sequence; Animal; Arylamine; N-Acetyltransferase; metabolism; Base; Blotting; Southern; Carnivora; genetics; Cats; Cytosol; enzymology; Dna; Human; Isoenzymes; Liver; Molecular; Data; Polymerase; Chain; Reaction; Rabbits; Homology; Nucleic Acid; Substrate; Specificity; Support; U.S.Gov't; P.H.S.; browse; nucleic; us; government; 130 |
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The purpose of this study was to determine the molecular basis for a relative deficiency in the cat of cytosolic arylamine N- acetyltransferase (NAT), an enzyme family that is important in the metabolism of xenobiotics and that normally consists of at least two related enzymes, NAT1 and NAT2. N-acetyltransferase in feline liver showed high affinity (mean Km = 2.1 microM) for p-aminobenzoic acid, an NAT1 selective substrate in humans and rabbits, but showed a very poor affinity (mean Km > 10 mM) for sulfamethazine, an NAT2 selective substrate in humans and rabbits. Immunoreactive N-acetyltransferase was detected in feline liver, bladder and colon using an NAT1-specific antipeptide antibody, but was not detected in any tissues using an NAT2- specific antibody. Southern blot analysis of genomic DNA demonstrated a single band in domestic cats using each of six restriction digests; single bands were also found on Southern blot analysis of six wild felids. The deduced amino acid sequence of the central portion of feline N-acetyltransferase, obtained by polymerase chain reaction amplification in both domestic cats and seven wild felids (lion, tiger, lynx, snow leopard, bobcat, Asian leopard cat and cheetah), contained three residues, Phe125, Arg127, and Tyr129, which determine NAT1-like substrate specificity in humans. These results support the conclusion that cytosolic arylamine N-acetylation activity is low in the cat because of the presence of a single N-acetyltransferase that has substrate specificity, immunogenicity and sequence characteristics similar to human NAT1, and that the unusual presence of only a single N- acetyltransferase gene appears to be a family wide trait shared by other felids. |
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0960-314x |
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Document Type: eng |
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SLN @ rana @ 345 |
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968 |
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Author |
Turner, L. |
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Title |
Oklahoma City Zoo-Twenty Nine Snow Leopards |
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Journal Article |
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1980 |
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Int.Ped Book of Snow Leopards |
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2 |
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96-111 |
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zoos; captivity; husbandry; zoo; breeding; housing; browse; 3690 |
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Discusses breeding, housing, aquisition, history |
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SLN @ rana @ 66 |
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974 |
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Author |
Wang, X.; Peng, J.; Zhou, H. |
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Title |
Preliminary observations on the distribution and status of dwarf blue sheep Pseudois schaeferi |
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2000 |
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Oryx |
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34 |
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1 |
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21-26 |
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Batang County of China; conservation; status; distribution; dwarf blue sheep; Pseudois schaeferi.; 5190 |
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Describes the drastic decline of the dwarf blue sheep since the 1950's primarily due to over-hunting. There are an estimated 200 individuals remaining in a 295 square km range in Batang county, China. The authors recommend urgent protection for this species. |
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Full text available at URL |
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SLN @ rana @ 504 |
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1004 |
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Wharton, D.; Mainka, S.A. |
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Title |
Management and husbandry of the snow leopard Uncia uncia |
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1997 |
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International Zoo Yearbook |
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35 |
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139-147 |
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breeding; captive-management; diet; enclosures; housing; husbandry; nutrition; veterinary-care; zoo; browse; veterinary; care; captive; management; 1290 |
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The international studbook for the Snow leopard Uncia uncia was established in 1976. The species has been the focus of intensive captive management and as at 1 January 1992, 541 animals were maintained at 160 collections. This paper gives an overview of the diet, housing, breeding and captive management of the species with specific reference to animals maintained in North American collections. A summary of veterinary care reported in the Snow leopard captive-management survey is also given. |
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Document Type: English |
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SLN @ rana @ 331 |
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1018 |
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Author |
White, S.D.; Stannard, A.A.; Ihrke, P.J.; Rosser, E.J. |
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Title |
Therapy of demodicosis in snow leopard challenged |
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1981 |
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J Am Vet Med Assoc |
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178 |
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9 |
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877-878 |
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Amoxicillin: therapeutic use; Animal; Animals; zoo; Calcium: therapeutic use; Carnivora; Mite Infestations: drug therapy; veterinary; Sulfides: therapeutic use; Thiosulfates: therapeutic use; amoxicillin; therapeutic; calcium; mite; infestations; drug; therapy; drug therapy; sulfides; thiosulfates; browse; use; 360 |
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0003-1488 |
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Document Type: eng |
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SLN @ rana @ 57 |
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1020 |
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Yanfa, L.; Huanwen, L. |
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A preliminary study on the rearing and breeding of ounce |
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1986 |
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Acta Theriologica Sinica |
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6 |
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2 |
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93-99 |
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captivity; husbandry; zoos; breeding; reproduction; mating; rearing; browse; 3710; Chinese |
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China |
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Document Type: Chinese |
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SLN @ rana @ 96 |
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1045 |
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McCarthy, T.; Murray, K.; Sharma, K.; Johansson, O. |
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Preliminary results of a long-term study of snow leopards in South Gobi, Mongolia |
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2010 |
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Cat News |
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Autumn |
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53 |
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15-19 |
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snow leopard, Mongolia, monitor, population, Panthera, Snow Leopard Trust, Snow Leopard Conservation Fund, South Gobi, ecology, radio collar, GPS-satellite collar, home range, camera trapping, fecal genetics, occupancy modeling |
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Snow leopards Panthera uncia are under threat across their range and require urgent conservation actions based on sound science. However, their remote habitat and cryptic nature make them inherently difficult to study and past attempts have provided insufficient information upon which to base effective conservation. Further, there has been no statistically-reliable and cost-effective method available to monitor snow leopard populations, focus conservation effort on key populations, or assess conservation impacts. To address these multiple information needs, Panthera, Snow Leopard Trust, and Snow Leopard Conservation Fund, launched an ambitious long-term study in Mongolia’s South Gobi province in 2008. To date, 10 snow leo-pards have been fitted with GPS-satellite collars to provide information on basic snow leopard ecology. Using 2,443 locations we calculated MCP home ranges of 150 – 938 km2, with substantial overlap between individuals. Exploratory movements outside typical snow leopard habitat have been observed. Trials of camera trapping, fecal genetics, and occupancy modeling, have been completed. Each method ex-hibits promise, and limitations, as potential monitoring tools for this elusive species. |
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SLN @ rana @ |
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1151 |
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Author |
Zhirjakov, V.A. |
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On the ecology of the snow leopard in the Zailisky-Alatau (Northern Tien Shan) |
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1990 |
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Int Ped Book of Snow Leopards |
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6 |
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25-30 |
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Tien-Shan; ecology; China; browse; Kazakhstan; Russia; Soviet-Union; distribution; population; prey; behavior; food-habits; scat-analysis; 3240 |
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Full text available at URL |
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SLN @ rana @ 168 |
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1078 |
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Author |
Chapron, G. |
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Title |
Re-wilding: other projects help carnivores stay wild |
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2005 |
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Nature |
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437 |
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318 |
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Acinonyx jubatus, carnivore, coexistence, conservation, damage prevention, Panthera leo, snow leopard, survival, Uncia uncia |
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Letter to Nature Editor, in response to: In their plea for bringing Pleistocene wildlife to the New World (“Re-wilding North America” Nature 436, 913–914; 2005), Josh Donlan and colleagues do not discuss successful efforts to ensure long-term survival of large carnivores in Africa and Asia. A few examples are given. |
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1114 |
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Author |
Christiansen, P. |
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Canine morphology in the larger Felidae: implications for feeding ecology |
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2007 |
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Biological Journal of the Linnean Society |
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91 |
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573-592 |
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bite force, canine, clouded leopard, feeding behaviour, felid, Homotherium serum, leopard, Megantereoncultridens, morphology, Neofelis nebulosa, paleontology, Panthera pardus, Panthera tigris, puma, Puma concolor, Smilodon fatalis, Smilodon populator, snow leopard, Uncia uncia |
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Canine morphology is analysed at seven intervals along the crown in both
anteroposterior and lateromedial perspective in seven species of large felids. The puma and the snow leopard have stout, rather conical canines, whereas those of lions, jaguars, and tigers bear substantial resemblance to each other, reflecting their phylogenetic relationships, and are less conical and large. The canines of the leopard are intermediate in morphology between those of the other species, probably reflecting its more generalized diet. The clouded leopard has very large and blade-like canines, which are different from the other analysed species. Canine bending strengths to estimated bite forces appear to differ less among the species than morphology,indicating that the evolution of canines has been constricted with respect to their strength in failure, probably owing to their being equally important for species fitness. However, the clouded leopard again stands out, having a high estimated bite force and rather weak canines in bending about the anteroposterior as well as lateromedial planes compared to the other species. Canine morphology to some extent reflects differences in killing mode, but also appears to be related to the phylogeny. The marked divergence of the clouded leopard is presently not understood. |
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SLN @ rana @ |
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1115 |
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