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Author |
Trepanier, L.A.; Cribb, A.E.; Spielberg, S.P.; Ray, K. |
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Title |
Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene |
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Journal Article |
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1998 |
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Pharmacogenetics |
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8 |
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2 |
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169-179 |
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Acetylation; Amino; Acid; Sequence; Animal; Arylamine; N-Acetyltransferase; metabolism; Base; Blotting; Southern; Carnivora; genetics; Cats; Cytosol; enzymology; Dna; Human; Isoenzymes; Liver; Molecular; Data; Polymerase; Chain; Reaction; Rabbits; Homology; Nucleic Acid; Substrate; Specificity; Support; U.S.Gov't; P.H.S.; browse; nucleic; us; government; 130 |
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The purpose of this study was to determine the molecular basis for a relative deficiency in the cat of cytosolic arylamine N- acetyltransferase (NAT), an enzyme family that is important in the metabolism of xenobiotics and that normally consists of at least two related enzymes, NAT1 and NAT2. N-acetyltransferase in feline liver showed high affinity (mean Km = 2.1 microM) for p-aminobenzoic acid, an NAT1 selective substrate in humans and rabbits, but showed a very poor affinity (mean Km > 10 mM) for sulfamethazine, an NAT2 selective substrate in humans and rabbits. Immunoreactive N-acetyltransferase was detected in feline liver, bladder and colon using an NAT1-specific antipeptide antibody, but was not detected in any tissues using an NAT2- specific antibody. Southern blot analysis of genomic DNA demonstrated a single band in domestic cats using each of six restriction digests; single bands were also found on Southern blot analysis of six wild felids. The deduced amino acid sequence of the central portion of feline N-acetyltransferase, obtained by polymerase chain reaction amplification in both domestic cats and seven wild felids (lion, tiger, lynx, snow leopard, bobcat, Asian leopard cat and cheetah), contained three residues, Phe125, Arg127, and Tyr129, which determine NAT1-like substrate specificity in humans. These results support the conclusion that cytosolic arylamine N-acetylation activity is low in the cat because of the presence of a single N-acetyltransferase that has substrate specificity, immunogenicity and sequence characteristics similar to human NAT1, and that the unusual presence of only a single N- acetyltransferase gene appears to be a family wide trait shared by other felids. |
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0960-314x |
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Document Type: eng |
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SLN @ rana @ 345 |
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968 |
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Author |
Turner, L. |
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Title |
Oklahoma City Zoo-Twenty Nine Snow Leopards |
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Journal Article |
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1980 |
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Int.Ped Book of Snow Leopards |
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2 |
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96-111 |
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zoos; captivity; husbandry; zoo; breeding; housing; browse; 3690 |
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Discusses breeding, housing, aquisition, history |
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SLN @ rana @ 66 |
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974 |
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Author |
ud Din, J. |
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Title |
Assessing the Status of Snow Leopard in Torkhow Valley, District Chitral, Pakistan: Final Technical Report |
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Report |
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Year |
2008 |
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1-16 |
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Keywords |
status; snow; snow leopard; snow-leopard; leopard; valley; chitral; Pakistan; Report; study; prey; Base; conflict; threats; threat; wildlife; sign; transect; surveys; survey; Slims; Data; number; snow leopards; snow-leopards; leopards; Animals; Animal; population; livestock; livestock depredation; livestock-depredation; depredation; area; Case; ungulates; ungulate; Himalayan; himalayan ibex; ibex; rut; using; prey species; prey-species; species; marmot; game; birds; carnivores; carnivore; wolf; wolves; jackal; fox; survival; retaliatory; retaliatory killing; retaliatory-killing; killing; poisoning; poaching; loss; habitat; habitat degradation; habitat-degradation; degradation; grazing; collection; awareness; Gis; map; staff; field; training; conservation; community; distribution; resource; project; network; program |
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This study was aimed at assessing the status of Snow leopard, its major prey base, and the extent of human-Snow leopard conflict and major threats to the wildlife in north Chitral (Torkhow valley) Pakistan. Snow leopard occurrence was conformed through sign transect surveys i.e. SLIMS. Based on the data collected the number of Snow leopards in this survey block (1022 Kmý) is estimated to be 2-3 animals. Comparing this estimate with the available data from other parts of the district the population of snow leopard in Chitral district was count to be 36 animals. Livestock depredation reports collected from the area reflect the existence of human-snow leopard conflict and 138 cases were recorded affecting 102 families (in a period of eight years, 2001-2008). Ungulates (Himalayan Ibex) rut season surveys were conducted in coordination with NWFP Wildlife department. A total of 429 animals were counted using direct count (point method) surveys. Other snow leopard prey species recorded include marmot, hare, and game birds. Signs of other carnivores i.e. wolf, jackal, and fox were also noticed. Major threats to the survival of wildlife especially snow leopard reckoned include retaliatory killing (Shooting, Poisoning), poaching, loss of natural prey, habitat degradation (over grazing, fodder and fuel wood collection), lack of awareness, and over population. GIS map of the study area was developed highlighting the area searched for Snow leopard and its prey species. Capacity of the Wildlife Department staff was built in conducting SLIMS and ungulate surveys through class room and on field training. Awareness regarding the importance of wildlife conservation was highlighted to the students, teachers and general community through lectures and distribution of resource materials developed by WWF-Pakistan. |
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Project funded by Snow Leopard Network's Snow Leopard Conservation Grant Program. |
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SLN @ rana @ 1065 |
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978 |
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Author |
Usgs; International Snow Leopard Trust |
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Title |
Snow Leopard Habitat Map |
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Map |
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Year |
1995 |
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map; habitat; 4860; snow; snow leopard; snow-leopard; leopard; range; Pakistan; resource; Division; trust; International; symposium; Jackson |
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ISLT and World Wide Fund for Nature - Pakistan |
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Pakistan |
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Snow leopard range map published in: Proceedings of the Eighth International Snow Leopard Symposium. Held in Islamabad, Pakistan 12-16 November 1995. Editors of proceedings: Rodney Jackson and Ashiq Ahmad. Map authors U.S.G.S. Biological Resources Division and Snow Leopard Trust. Page 9. |
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Call Number |
SLN @ rana @ 471 |
Serial |
979 |
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Author |
Vashetko, E.; Esipov A.; Bykova, E.; Kreuzberg, E. |
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Title |
Snow Leopard Bibliography. Central Asia (Abstracts) |
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Manuscript |
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2005 |
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analysis; asia; bibliography; central; Central Asia; conservation; ecology; International; International-Snow-Leopard-Trust; international snow leopard trust; Islt; leopard; project; region; Russian; snow; snow-leopard; snow leopard; species; trust; work |
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Bibliography of the Snow Leopard included publications on the studying various questions of ecology and conservation of the Snow Leopard in Central Asia (305) for the period 1873 to 2004. The most important works on this species in the region, as well as results of the analysis of timing of publications was described. |
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English version. Also available in Russian in the SLN bibliography. Project supported by International Snow Leopard Trust (ISLT), was carried out in 2004-2005. |
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SLN @ rana @ 1061 |
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983 |
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Volozheninov, N.N. |
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Rare and vanishing mammals and birds in S Uzbekistan. Ecology and protection of the rare and vanishing vertebrates in Uzbekistan, Tashkent |
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Book Whole |
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1985 |
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Uzbekistan; Russia; Soviet-Union; Ussr; browse; soviet union; soviet; union; 2610; Russian |
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In Russian |
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SLN @ rana @ 90 |
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991 |
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Title |
Miraki Reservation, Chatkal Reservation |
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Miscellaneous |
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1978 |
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9-11 |
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Uzbekistan; Chatkal nature reserve; Miraki nature reserve; landscapes; flora; fauna; natural monuments; snow leopard.; 7670; Russian |
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It describes history of the Miraki and Chatkal nature reserves' establishment and provides data concerning area, landscapes, altitude zoning, flora and fauna as well as natural monuments. |
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Full text available in RussianJournal Title: Uzbekistan's Reservations and Natural Monuments. XIV General Assembly of the International Union for Conservation of Nature and Natural Resources. |
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SLN @ rana @ 745 |
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13 |
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Title |
Rare Animals and their Protection in the USSR |
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Miscellaneous |
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1978 |
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4-4 |
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Uzbekistan; categories of threat; rare species; snow leopard; distribution; threats.; 8030; Russian |
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It described categories of threat (Category A and Category B). Snow leopard was assessed under Category A the species whose numbers and habitats have sharply diminished and are continuing to diminish as a consequence of direct persecution, destruction of their habitat or other causes. The snow leopard (Pardus uncia) inhabits the mountains of the Tien Shan range, Tarbagatai, Saur, Altai and the Sayans. Exploitation of mountain areas and depletion of stocks of wild ungulates (Siberian mountain goats and wild sheep) have led to a sharp reduction in the number of snow leopards. It is estimated that today only about one thousand leopards are left, and they have accordingly been placed under complete protection. Hunting and selective shooting are everywhere prohibited. Catching leopards is regulated by the articles of the international convention restricting trade in rare species of plants and animals. |
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Full text available in RussianJournal Title: Uzbekistan's Reservations and Natural Monuments. XIV General Assembly of the International Union for Conservation of Nature and Natural Resources. |
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SLN @ rana @ 781 |
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14 |
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Biological diversity conservation. National strategy and action plan of the Republic of Uzbekistan |
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1998 |
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34-35 |
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Uzbekistan; national strategy and action plan; biodiversity; endangered species; snow leopard; distribution; number; conservation measures.; 6280; Russian |
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The National strategy and action plan of the Republic of Uzbekistan was signed on April 1, 1998. Snow leopard was included in the list of rare and endangered animal species and referred to category 2 a rare, not endangered species. It is distributed in highlands of the West Tien Shan and Pamiro-Alay. Its population is 30-50 animals. Snow leopard is protected in the Chatkal, Gissar nature reserve, and Ugam-Chatkal national park. |
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Full text available in Russian |
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SLN @ rana @ 606 |
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17 |
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Biological resources |
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Miscellaneous |
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2002 |
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24-25 |
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Uzbekistan; biodiversity; vertebrates; snow leopard.; 6290; Russian |
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It provides a summary of plant and animal resources in Uzbekistan. Among 15,000 animal species, 664 are vertebrate species including 424 bird, 97 mammal, 83 fish, 59 reptile and three amphibian species. Snow leopard, snow cock, ibex, and other species are typical for highlands. |
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Full text available in Russian Journal Title: First national report of the Republic of Uzbekistan on Framework Convention of UN on climate change. |
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SLN @ rana @ 607 |
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18 |
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