Abstract: 41 percent of all vertebrate species listed in the Red Book of the Uzbek SSR (18 mammal species, 29 bird, 6 reptile, and 8 fish species) inhabit the Kashkadarya region. The mammals are Tien Shan brown bear, Central Asian otter, Turkistan lynx, snow leopard, and goitered gazelle. Nesting bird fauna includes the following species: black stork, Turkistan white stork, short toed eagle, booted eagle, golden eagle, bearded vulture, black vulture, griffon vulture, saker falcon, houbara bustard, and eagle owl. Migrating and wintering bird species are dalmatian pelican, rose pelican, mute swan, osprey, tawny eagle, imperial eagle, pin-tailed sandgrouse; and possibly Bonnli's eagle and Barbary falcon that have not been seen here since 1950-s. Rare reptiles are represented by two species: desert monitor and Central Asian cobra.