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Author |
Trepanier, L.A.; Cribb, A.E.; Spielberg, S.P.; Ray, K. |
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Title |
Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene |
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Journal Article |
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Year |
1998 |
Publication |
Pharmacogenetics |
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8 |
Issue |
2 |
Pages |
169-179 |
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Keywords |
Acetylation; Amino; Acid; Sequence; Animal; Arylamine; N-Acetyltransferase; metabolism; Base; Blotting; Southern; Carnivora; genetics; Cats; Cytosol; enzymology; Dna; Human; Isoenzymes; Liver; Molecular; Data; Polymerase; Chain; Reaction; Rabbits; Homology; Nucleic Acid; Substrate; Specificity; Support; U.S.Gov't; P.H.S.; browse; nucleic; us; government; 130 |
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Abstract |
The purpose of this study was to determine the molecular basis for a relative deficiency in the cat of cytosolic arylamine N- acetyltransferase (NAT), an enzyme family that is important in the metabolism of xenobiotics and that normally consists of at least two related enzymes, NAT1 and NAT2. N-acetyltransferase in feline liver showed high affinity (mean Km = 2.1 microM) for p-aminobenzoic acid, an NAT1 selective substrate in humans and rabbits, but showed a very poor affinity (mean Km > 10 mM) for sulfamethazine, an NAT2 selective substrate in humans and rabbits. Immunoreactive N-acetyltransferase was detected in feline liver, bladder and colon using an NAT1-specific antipeptide antibody, but was not detected in any tissues using an NAT2- specific antibody. Southern blot analysis of genomic DNA demonstrated a single band in domestic cats using each of six restriction digests; single bands were also found on Southern blot analysis of six wild felids. The deduced amino acid sequence of the central portion of feline N-acetyltransferase, obtained by polymerase chain reaction amplification in both domestic cats and seven wild felids (lion, tiger, lynx, snow leopard, bobcat, Asian leopard cat and cheetah), contained three residues, Phe125, Arg127, and Tyr129, which determine NAT1-like substrate specificity in humans. These results support the conclusion that cytosolic arylamine N-acetylation activity is low in the cat because of the presence of a single N-acetyltransferase that has substrate specificity, immunogenicity and sequence characteristics similar to human NAT1, and that the unusual presence of only a single N- acetyltransferase gene appears to be a family wide trait shared by other felids. |
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0960-314x |
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Document Type: eng |
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Call Number |
SLN @ rana @ 345 |
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968 |
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Mongolian Biosphere & Ecology Association |
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Title |
Mongolian Biosphere & Ecology Association Report March 2010 |
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Manuscript |
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Year |
2010 |
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Keywords |
nature; tourism; surveys; survey; snow; snow leopards; snow leopard; snow-leopards; snow-leopard; leopards; leopard; attack; domestic; Animals; Animal; illegal; illegal hunting; hunting; territory; province; 2010; hunt; 1990; movements; movement; pasture; desert; number; species; birds; river; mountain; hunters; hunter; recent; government; structure; management; national; central; people; Report; gobi; Gobi Desert; reproduction; Adult; meat; food; ibex; wild; wild sheep; sheep; marmot; nutrition; schools; population; use; local; big; big game; big-game; game; 310; mountains; wolves; wolf; Seasons; times; zones; global; Mongolia; 40; history; ecology |
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Abstract |
In accordance with order of the Ministry of Nature and Tourism,
zoologists of our association have made surveys in three ways such as
reasons why snow leopards attack domestic animals, “Snow leopard” trial
operation to count them and illegal hunting in territories of Khovd,
Gobi-Altai, Bayankhongor, Uvurkhangai and Umnugobi provinces from
September 2009 to January 2010. As result of these surveys it has made
the following conclusions in the followings: Reason to hunt them illegally: the principal reason is that
administrative units have been increased and territories of
administrative units have been diminished. There have been four
provinces in 1924 to 1926, 18 since 1965, 21 since 1990. Such situation
limits movements of herdsmen completely and pastures digressed much than
ever before. As result of such situation, 70% of pastures become desert.
Such digression caused not only heads of animals and also number of
species. Guarantee is that birds such as owls, cuckoo, willow grouse in
banks of Uyert river, Burkhanbuudai mountain, located in Biger soum,
Gobi-Altai province, which are not hunted by hunters, are disappearing
in the recent two decades. For that reason we consider it is urgently
necessary for the government to convert administrative unit structures
into four provinces. This would influence herdsmen moving across
hundreds km and pastures could depart from digression.
Second reason: cooperative movement won. The issues related to management and strengthening of national
cooperatives, considered by Central Committee of Mongolian People's
Revolutionary Party in the meeting in March 1953 was the start of
cooperatives' movement. Consideration by Yu. Tsedenbal, chairman of
Ministers Council, chairman of the MPRP, on report “Result of to unify
popular units and some important issues to maintain entity management of
agricultural cooperatives” in the fourth meeting by the Central
Committee of Mongolian People's Revolutionary Party /MPRP/ on December
16-17, 1959, proclaimed complete victory of cooperative. At the end of
1959, it could unify 767 small cooperative into 389 ones, unify 99.3 %
of herdsmen and socialize 73.3 % of animals. The remaining of animals
amount 6 million 163 thousands animals, and equals to 26.7% of total
animals. This concerned number of animals related to the article
mentioned that every family should have not more that 50 animals in
Khangai zone and not more 75 animals in Gobi desert. It shows that such
number could not satisfy needs of family if such number is divided into
five main animals in separating with reproduction animals and adult
animals. So herdsmen started hunt hoofed animals secretly and illegally
in order to satisfy their meat needs. Those animals included main food
of snow leopard such as ibex, wild sheep, and marmot. Third reason is that the state used to hunt ibex, which are main
nutrition of snow leopards, every year. The administrative unit of the
soum pursued policy to hunt ibex in order to provide meat needs of
secondary schools and hospitals. That's why this affected decrease of
ibex population. Preciously from 1986 to 1990 the permissions to hunt
one thousands of wild sheep and two thousands of ibexes were hunt for
domestic alimentary use every year. Not less than 10 local hunters of every soum used to take part in big
game of ibexes. Also they hunted many ibexes, chose 3-10 best ibexes and
hid them in the mountains for their consummation during hunting.
Fourth reason: hunting of wolves. Until 1990 the state used to give
prizes to hunter, who killed a wolf in any seasons of the year. Firstly
it offered a sheep for the wolf hunter and later it gave 25 tugrugs /15
USD/. Every year, wolf hunting was organized several times especially
picking wolf-cubs influenced spread and population of wolves. So snow
leopard came to the places where wolves survived before and attack
domestic animals. Such situation continued until 1990. Now population of
ibexes has decreased than before 1990 since the state stopped hunting
wolves, population of wolves increased in mountainous zones. We didn't
consider it had been right since it was natural event. However
population of ibexes decreased. Fifth reason: Global warming. In recent five years it has had a drought
and natural disaster from excessive snow in the places where it has
never had such natural disasters before. But Mongolia has 40 million
heads of domestic animals it has never increased like such quantity in
its history before. We consider it is not incorrect that decrease of
domestic animals could give opportunities to raise population of wild
animals. Our next survey is to make attempt to fix heads of snow leopards
correctly with low costs. |
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Call Number |
SLN @ rana @ 1100 |
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705 |
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Author |
Chalise, M.K. |
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Title |
Nepalka Samrakshit Banyajantu (Nepal's Protected Wildlife in Nepali language) |
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Book Whole |
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2008 |
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Abbreviated Journal |
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106-108 |
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Keywords |
government; language; leopard; leopards; Nepal; protected; snow; snow-leopard; snow-leopards; snow leopard; snow leopards; wildlife |
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Shajha Prakashan |
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Lalitpur, Kathmandu |
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In Nepalese language only. Includes only the chapter on snow leopards and the book cover. The book is published by a government corporate house of publication. |
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Call Number |
SLN @ rana @ 1058 |
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211 |
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Author |
Khan, A.A. |
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Title |
Strategic plan for the conservation of the snow leopard in Pakistan |
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Report |
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2001 |
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1-17 |
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Keywords |
plan; conservation; snow; snow leopard; snow-leopard; leopard; Pakistan; government; Wwf; International; international snow leopard trust; International-Snow-Leopard-Trust; trust |
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WWF Pakistan & International Snow Leopard Trust |
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Pakistan |
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Draft – approved by stakeholders & submitted to government. WWF Pakistan & International Snow Leopard Trust. |
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SLN @ rana @ 1003 |
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531 |
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Author |
Zahler, P.; Graham, P. |
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Title |
War and wildlife: the Afghanistan conflict and its effects on the environment |
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Report |
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2001 |
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1-10 |
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war; wildlife; Afghanistan; conflict; effects; environment; International; international snow leopard trust; International-Snow-Leopard-Trust; snow; snow leopard; snow-leopard; leopard; trust; Islt; environmental; Organization; conservation; endangered; mountain; mountain ecosystem; mountain-ecosystem; ecosystem; approach; local; local people; people; Media; government; public; Report |
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The International Snow Leopard Trust (ISLT) is a nonprofit environmental organization dedicated to the conservation of the endangered snow leopard and its mountain ecosystem through a balanced approach that considers the needs of the local people and the environment. As such, we wish to stress that the ISLT does not have a position regarding the present conflict in Afghanistan. However, this organization believes that there are important repercussions regarding this conflict that have yet to be addressed in the media, within government circles, or among the public. This report documents some of these repercussions so that they may be included in the present dialog. |
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International Snow Leopard Trust |
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Seattle |
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ISLT special report. Peter Zahler from Wildlife Conservation Society & Peter Graham from ISLT. |
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SLN @ rana @ 975 |
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1067 |
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Author |
Villarrubia, C.; Jackson, R. |
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Title |
Snow Leopard Conservation on a Regional Basis: Elements in Planning Protected Areas |
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Conference Article |
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1994 |
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253-263 |
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conservation; protected-area; parks; reserves; refuge; planning; governments; local-peoples; herders; livestock; life-history; home-range; seasonal-shifts; core-areas; dispersal; habitat; ecology; fragmentation; buffers; zones; corridors; barriers; browse; protected; area; local people; local; history; home range; seasonal; shifts; core; 3540 |
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Islt |
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Usa |
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J.L.Fox; D.Jizeng |
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Full text available at URLTitle, Monographic: Seventh International Snow Leopard SymposiumPlace of Meeting: ChinaDate of Copyright: 1994 |
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SLN @ rana @ 264 |
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986 |
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