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| Author | Trepanier, L.A.; Cribb, A.E.; Spielberg, S.P.; Ray, K. | ||||
| Title | Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene | Type | Journal Article | ||
| Year | 1998 | Publication | Pharmacogenetics | Abbreviated Journal | |
| Volume | 8 | Issue | 2 | Pages | 169-179 |
| Keywords | Acetylation; Amino; Acid; Sequence; Animal; Arylamine; N-Acetyltransferase; metabolism; Base; Blotting; Southern; Carnivora; genetics; Cats; Cytosol; enzymology; Dna; Human; Isoenzymes; Liver; Molecular; Data; Polymerase; Chain; Reaction; Rabbits; Homology; Nucleic Acid; Substrate; Specificity; Support; U.S.Gov't; P.H.S.; browse; nucleic; us; government; 130 | ||||
| Abstract | The purpose of this study was to determine the molecular basis for a relative deficiency in the cat of cytosolic arylamine N- acetyltransferase (NAT), an enzyme family that is important in the metabolism of xenobiotics and that normally consists of at least two related enzymes, NAT1 and NAT2. N-acetyltransferase in feline liver showed high affinity (mean Km = 2.1 microM) for p-aminobenzoic acid, an NAT1 selective substrate in humans and rabbits, but showed a very poor affinity (mean Km > 10 mM) for sulfamethazine, an NAT2 selective substrate in humans and rabbits. Immunoreactive N-acetyltransferase was detected in feline liver, bladder and colon using an NAT1-specific antipeptide antibody, but was not detected in any tissues using an NAT2- specific antibody. Southern blot analysis of genomic DNA demonstrated a single band in domestic cats using each of six restriction digests; single bands were also found on Southern blot analysis of six wild felids. The deduced amino acid sequence of the central portion of feline N-acetyltransferase, obtained by polymerase chain reaction amplification in both domestic cats and seven wild felids (lion, tiger, lynx, snow leopard, bobcat, Asian leopard cat and cheetah), contained three residues, Phe125, Arg127, and Tyr129, which determine NAT1-like substrate specificity in humans. These results support the conclusion that cytosolic arylamine N-acetylation activity is low in the cat because of the presence of a single N-acetyltransferase that has substrate specificity, immunogenicity and sequence characteristics similar to human NAT1, and that the unusual presence of only a single N- acetyltransferase gene appears to be a family wide trait shared by other felids. | ||||
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| ISSN | 0960-314x | ISBN | Medium | ||
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Document Type: eng | Approved | no | ||
| Call Number | SLN @ rana @ 345 | Serial | 968 | ||
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| Author | Guerrero, D. | ||||
| Title | Animal behavior concerns & solutions: snow leopard (Uncia uncia) evaluation, zoo | Type | Journal Article | ||
| Year | 1998 | Publication | Anim.Keepers' Forum | Abbreviated Journal | |
| Volume | 25 | Issue | 2 | Pages | 56-58 |
| Keywords | aggressive-behavior; behavior; captive-animal-care; diets; endangered; threatened-species; genetics; handling-methods; intraspecies-relationships; social-behavior; husbandry; zoos; snow leopard; aggressive; captive; Animal; care; threatened; species; handling; methods; intraspecies; relationships; social; browse; 1310 | ||||
| Abstract | The author offers advice on how a captive-raised snow leopard cub could be acclimated to humans so it could be used as a zoo “ambassador”. The cub had negative experiences with humans and lacked socialization with other animals and conspecifics. Methods of avoiding and redirecting the cub's aggressive behavior are suggested. lgh. | ||||
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Ark Anim., Inc., P.O. Box 1154, Escondido, CA 92033-1154. e-mail: arkabc@arkanimals.com Document Type: English | Approved | no | ||
| Call Number | SLN @ rana @ 338 | Serial | 358 | ||
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| Author | Roth, T.L.; Swanson, W.F.; Wildt, D.E. | ||||
| Title | Snow leopard (Panthera unica) sperm longevity in vitro is not influenced by protein or energy source supplements but is affected by buffer source | Type | Journal Article | ||
| Year | 1995 | Publication | Theriogenology | Abbreviated Journal | |
| Volume | 43 | Issue | 1 | Pages | 309 |
| Keywords | genetics; Sperm; captivity; medical; medicine; veterinary; zoo; breeding; browse; 1400 | ||||
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Annual Conference of the International Embryo Transfer Society, Calgary, Alberta, Canada, January 8-10, 1995 Document Type: English Call Number: QP251 .T44 | Approved | no | ||
| Call Number | SLN @ rana @ 280 | Serial | 829 | ||
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| Author | Atzeni, L., Wang, J., Riordan, P., Shi, K., Cushman, S. A. | ||||
| Title | Landscape resistance to gene flow in a snow leopard population from Qilianshan National Park, Gansu, China | Type | Journal Article | ||
| Year | 2023 | Publication | Landscape Ecology | Abbreviated Journal | |
| Volume | Issue | Pages | |||
| Keywords | Landscape genetics · MLPE · Gene flow · Genetic distance · Isolation by distance · Isolation by resistance · Landscape resistance · Snow leopard · Principal component analysis | ||||
| Abstract | Context: The accurate estimation of landscape resistance to movement is important for ecological understanding and conservation applications. Rigorous estimation of resistance requires validation and optimization. One approach uses genetic data for the optimization or validation of resistance models. Objectives We used a genetic dataset of snow leopards from China to evaluate how landscape genetics resistance models varied across genetic distances and spatial scales of analysis. We evaluated whether landscape genetics models were superior to models of resistance derived from habitat suitability or isolation-by-distance. Methods: We regressed genetically optimized, habitat-based, and isolation-by-distance hypotheses against genetic distances using mixed effect models. We explored all subset combinations of genetically optimized variables to find the most supported resistance scenario for each genetic distance. Results: Genetically optimized models always out-performed habitat-based and isolation-by-distance hypotheses. The choice of genetic distances influenced the apparent influence of variables, their spatial scales and their functional response shapes, producing divergent resistance scenarios. Gene flow in snow leopards was largely facilitated by areas of intermediate ruggedness at intermediate elevations corresponding to small-to-large valleys within and between the mountain ranges. Conclusions: This study highlights that landscape genetics models provide superior estimation of functional dispersal than habitat surrogates and suggests that optimization of genetic distance should be included as an optimization routine in landscape genetics, along with variables, scales, effect size and functional response shape. Furthermore, our study provides new insights on the ecological conditions that promote gene flow in snow leopards, which expands ecological knowledge, and we hope will improve conservation planning. |
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Approved | no | |||
| Call Number | SLN @ rakhee @ | Serial | 1720 | ||
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| Author | Hacker, C., Atzeni, L., Munkhtsog, B., Munkhtsog, B., Galsandorj, N., Zhang, Y., Liu, Y., Buyanaa, C., Bayandonoi, G., Ochirjav, M., Farrington, J. D., Jevit, M., Zhang, Y., Wu, L. Cong, W., Li, D., Gavette, C., Jackson, R., Janecka, J. E. | ||||
| Title | Genetic diversity and spatial structures of snow leopards (Panthera uncia) reveal proxies of connectivity across Mongolia and northwestern China | Type | Journal Article | ||
| Year | 2022 | Publication | Landscape Ecology | Abbreviated Journal | |
| Volume | Issue | Pages | 1-19 | ||
| Keywords | Admixture · Central Asia · Connectivity · Habitat Modeling · Landscape Genetics · Noninvasive Genetics · MEM · Spatial Structures | ||||
| Abstract | Understanding landscape connectivity and population genetic parameters is imperative for threatened species management. However, such information is lacking for the snow leopard (Panthera uncia). This study sought to explore hierarchical snow leopard gene flow patterns and drivers of genetic structure in Mongolia and China. A total of 97 individuals from across Mongolia and from the north-eastern edge of the Qinghai-Tibetan Plateau in Gansu Province to the middle of Qinghai Province in China were genotyped across 24 microsatellite loci. Distance-based frameworks were used to determine a landscape scenario best explaining observed genetic structure. Spatial and non-spatial methods were used to investigate fine-scale autocorrelation and similarity patterns as well as genetic structure and admixture. A genetic macro-division between populations in China and Mongolia was observed, suggesting that the Gobi Desert is a substantial barrier to gene flow. However, admixture and support for a resistance-based mode of isolation suggests connective routes that could facilitate movement. Populations in Mongolia had greater connectivity, indicative of more continuous habitat. Drivers of genetic structure in China were difficult to discern, and fine-scale sampling is needed. This study elucidates snow leopard landscape connectivity and helps to prioritize conservation areas. Although contact zones may have existed and occasional crossings can occur, establishing corridors to connect these areas should not be a priority. Focus should be placed on maintaining the relatively high connectivity for snow leopard populations within Mongolia and increasing research efforts in China. | ||||
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Approved | no | |||
| Call Number | SLN @ rakhee @ | Serial | 1717 | ||
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| Author | Aruge, S., Batool, H., Khan, F. M., Abbas, F. I., Janjua, S | ||||
| Title | A pilot study�genetic diversity and population structure of snow leopards of Gilgit-Baltistan, Pakistan, using molecular techniques. | Type | Journal Article | ||
| Year | 2019 | Publication | PeerJ | Abbreviated Journal | |
| Volume | Issue | 7672 | Pages | 1-14 | |
| Keywords | Population, Genetics, Panthera uncia, Pakistan, Molecular markers | ||||
| Abstract | Background: The Hindu Kush and Karakoram mountain ranges in Pakistan�s northern areas are a natural habitat of the snow leopard (Panthera uncia syn. Uncia uncia) but the ecological studies on this animal are scarce since it is human shy by nature and lives in dif!cult mountainous tracts. The pilot study is conducted to exploit the genetic diversity and population structure of the snow leopard in this selected natural habitat of the member of the wildcat family in Pakistan. Method: About 50 putative scat samples of snow leopard from !ve localities of Gilgit-Baltistan (Pakistan) along with a control sample of zoo maintained male snow leopard were collected for comparison. Signi!cant quality and quantity of genomic DNA was extracted from scat samples using combined Zhang�phenol�chloroform method and successful ampli!cation of cytochrome c oxidase I gene (190 bp) using mini-barcode primers, seven simple sequence repeats (SSR) markers and Y-linked AMELY gene (200 bp) was done. Results: Cytochrome c oxidase I gene sequencing suggested that 33/50 (66%) scat samples were of snow leopard. AMELY primer suggested that out of 33 ampli!ed samples, 21 (63.63%) scats were from male and 12 (36.36%) from female leopards. Through successful ampli!cation of DNA of 25 out of 33 (75.75%) scat samples using SSR markers, a total of 68 alleles on seven SSR loci were identi!ed, showing low heterozygosity, while high gene "ow between population. Discussion: The low gene flow rate among the population results in low genetic diversity causing decreased diversi!cation. This affects the adaptability to climatic changes, thus ultimately resulting in decreased population size of the species. |
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Approved | no | |||
| Call Number | SLN @ rakhee @ | Serial | 1491 | ||
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| Author | Rodgers, T. W.,Janecka, J. E. | ||||
| Title | Applications and techniques for non-invasive faecal genetics research in felid conservation | Type | Journal Article | ||
| Year | 2013 | Publication | Abbreviated Journal | ||
| Volume | Issue | Pages | |||
| Keywords | Conservation . Elusive species . Faecal DNA . Felidae . Non-invasive genetics | ||||
| Abstract | Non-invasive genetic techniques utilising DNA extracted from faeces hold great promise for felid conservation research. These methods can be used to establish species distributions, model habitat requirements, analyse diet, estimate abundance and population density, and form the basis for population, landscape and conservation genetic analyses. Due to the elusive nature of most felid species, non-invasive genetic methods have the potential to provide valuable data that cannot be obtained with traditional observational or capture techniques. Thus, these methods are particularly valuable for research and conservation of endangered felid species. Here, we review recent studies that use non-invasive faecal genetic techniques to survey or study wild felids; provide an overview of field, laboratory and analysis techniques; and offer suggestions on how future non-invasive genetic studies can be expanded or improved to more effectively support conservation. |
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Approved | no | |||
| Call Number | SLN @ rakhee @ | Serial | 1430 | ||
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| Author | Janecka, J. E., Jackson, R., Munkhtsog, B., Murphy, W. J. | ||||
| Title | Characterization of 9 microsatellites and primers in snow leopards and a species-specific PCR assay for identifying noninvasive samples | Type | Journal Article | ||
| Year | 2014 | Publication | Conservation Genetic Resource | Abbreviated Journal | |
| Volume | 6 | Issue | 2 | Pages | 369:373 |
| Keywords | Microsatellites,Cytochrome b, Snow Leopard, Noninvasive genetics, Individual identification | ||||
| Abstract | Molecular markers that can effectively identify noninvasively collected samples and provide genetic information are critical for understanding the distribution, status, and ecology of snow leopards (Panthera uncia). However, the low DNA quantity and quality in many noninvasive samples such as scats makes PCR amplification and genotyping challenging. We therefore designed primers for 9 microsatellites loci previously isolated in the domestic cat (Felis catus) specifically for snow leopard studies using noninvasive samples. The loci showed moderate levels of variation in two Mongolian snow leopard populations. Combined with seven other loci that we previously described, they have sufficient variation (He = 0.504, An = 3.6) for individual identification and population structure analysis. We designed a species species specific PCR assay using cytochrome b for identification of unknown snow leopard samples. These molecular markers facilitate in depth studies to assess distribution, abundance, population structure, and landscape connectivity of this endangered species. |
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Approved | no | |||
| Call Number | SLN @ rakhee @ | Serial | 1428 | ||
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| Author | Janecka, J. E., Jackson, R., Munkhtsog, B., Murphy, W. J. | ||||
| Title | Characterization of 9 microsatellites and primers in snow leopards and a species-specific PCR assay for identifying noninvasive samples | Type | Journal Article | ||
| Year | 2014 | Publication | Conservation Genetic Resource | Abbreviated Journal | |
| Volume | 6 | Issue | 2 | Pages | 369:373 |
| Keywords | Microsatellites,Cytochrome b, Snow Leopard, Noninvasive genetics, Individual identification | ||||
| Abstract | Molecular markers that can effectively identify noninvasively collected samples and provide genetic information are critical for understanding the distribution, status, and ecology of snow leopards (Panthera uncia). However, the low DNA quantity and quality in many noninvasive samples such as scats makes PCR amplification and genotyping challenging. We therefore designed primers for 9 microsatellites loci previously isolated in the domestic cat (Felis catus) specifically for snow leopard studies using noninvasive samples. The loci showed moderate levels of variation in two Mongolian snow leopard populations. Combined with seven other loci that we previously described, they have sufficient variation (He = 0.504, An = 3.6) for individual identification and population structure analysis. We designed a species species specific PCR assay using cytochrome b for identification of unknown snow leopard samples. These molecular markers facilitate in depth studies to assess distribution, abundance, population structure, and landscape connectivity of this endangered species. endangered species |
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Approved | no | |||
| Call Number | SLN @ rakhee @ | Serial | 1427 | ||
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| Author | Manati, A.R. | ||||
| Title | Fur trade of large cats and the question of the subspecies status of leopards in Afghanistan (Der Handel mit Fellen von Grosskatzen und die Abklärung der Unterartenfrage beim | Type | Book Whole | ||
| Year | 2008 | Publication | Abbreviated Journal | ||
| Volume | Issue | Pages | 125 | ||
| Keywords | fur trade, genetics, leopard, Panthera pardus, snow leopard, subspecies, Uncia uncia | ||||
| Abstract | Over a time of four years the bazars of Afghanistan were surveyed for furs of spotted wild cats, in particular leopards and snow leopards. In 2004 in Kabul a total of 28 furs of leopards were purchased by shopkeepers and 21 sold at an average price of 825 $. In the same year 25 furs of snow leopards were purchased and 19 sold to clients at an average price of 583 $. In 2006 at a single inspection double as many furs of leopards were found to be offered for sale in comparison to the whole year of 2004. Also prices had increased over the two years by 20 % to an average of 1037 $. Similarly the number of furs of snow leopards at 21 pieces was higher than in 2004, and the prices had increased to an average of 652 $. In 2007 investigations rendered more difficult, because the authorities had started to control the fur trade, and the results are not unequivocal. Clients were without any exception foreigners. Surveys in 2004 in Mazar-e-Sharif, Kunduz, Takhar and Faiz Abad, in 2006 additionally in Baharak and Iskashem in the province of Badakhshan, revealed a regular trade in furs of spotted cats, however not as extensive as in Kabul. The most interesting finding was a fur of a cheetah in Mazar-e-Sharif, the first record of this species after 35 years. From the surveys can be concluded that leopards still exist in the whole range of its distribution area in Afghanistan. However they don't allow any conclusion on the population size and its threat by hunting. In contrast to the leopard there exists a recent estimation of the population size of the snow leopard, saying that there are still 100 to 200 snow leopards living in Afghanistan. On the basis of these figures as well as the numbers of furs traded annually a Population and Habitat Viability Analysis was conducted. The result of this analysis is alarming. It has to be assumed that the snow leopard will be extinct in Afghanistan within the next ten years. To improve the protection of spotted cats in Afghanistan it needs both, a better implementation of the existing legislation as well as an awareness campaign among potential clients, i. e. foreigners living in Afghanistan. The second part of this thesis deals with the question of subspecies of leopards in Afghanistan. Out of the 27 subspecies described four are believed to exist in Afghanistan. However, according to a molecularbiological revision of the species there occurs only one subspecies in Afghanistan, Panthera pardus saxicolor. To clarify the subspecies question various measures of furs had been taken in the bazars. The results revealed that the leopards in Afghanistan are the biggest of its species. However a further differentiation according to the area of origin within the country was not possible. Also the traditional differentiation on the basis of colours and patterns on the furs was not possible. In contrast to the molecularbiological investigations published not only samples of zoo animals were available in this study but also samples from the wild. The own results confim that almost all leopards from Afghanistan and Iran belong to one and the same subspecies, P. p. saxicolor. Only in the most eastern part of Afghanistan, the Indian leopard, Panthera pardus fusca, can be found. The International Studbook for the Persian Leopard was analysed. The whole population derives from a few founder animals, which were imported in the midth fifties from Iran and in the late sixties from Afghanistan. To avoid inbreeding later on the Iranian and the Afghan lines were mixed. A female imported in 1968 from Kabul to Cologne is represented in each of the more than 100 today living animals.Mixing the two lines subsequently is justified by the genetic results of this study. Recently acquired animals from the Caucasus, however, should be tested genetically before integrating them into the zoo population. |
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| Publisher | University of Köln | Place of Publication | Germany | Editor | |
| Language | German | Summary Language | Original Title | ||
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Approved | no | |||
| Call Number | SLN @ rana @ | Serial | 1123 | ||
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