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Author |
Trepanier, L.A.; Cribb, A.E.; Spielberg, S.P.; Ray, K. |
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Title |
Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene |
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Journal Article |
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Year |
1998 |
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Pharmacogenetics |
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Volume |
8 |
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2 |
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169-179 |
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Acetylation; Amino; Acid; Sequence; Animal; Arylamine; N-Acetyltransferase; metabolism; Base; Blotting; Southern; Carnivora; genetics; Cats; Cytosol; enzymology; Dna; Human; Isoenzymes; Liver; Molecular; Data; Polymerase; Chain; Reaction; Rabbits; Homology; Nucleic Acid; Substrate; Specificity; Support; U.S.Gov't; P.H.S.; browse; nucleic; us; government; 130 |
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The purpose of this study was to determine the molecular basis for a relative deficiency in the cat of cytosolic arylamine N- acetyltransferase (NAT), an enzyme family that is important in the metabolism of xenobiotics and that normally consists of at least two related enzymes, NAT1 and NAT2. N-acetyltransferase in feline liver showed high affinity (mean Km = 2.1 microM) for p-aminobenzoic acid, an NAT1 selective substrate in humans and rabbits, but showed a very poor affinity (mean Km > 10 mM) for sulfamethazine, an NAT2 selective substrate in humans and rabbits. Immunoreactive N-acetyltransferase was detected in feline liver, bladder and colon using an NAT1-specific antipeptide antibody, but was not detected in any tissues using an NAT2- specific antibody. Southern blot analysis of genomic DNA demonstrated a single band in domestic cats using each of six restriction digests; single bands were also found on Southern blot analysis of six wild felids. The deduced amino acid sequence of the central portion of feline N-acetyltransferase, obtained by polymerase chain reaction amplification in both domestic cats and seven wild felids (lion, tiger, lynx, snow leopard, bobcat, Asian leopard cat and cheetah), contained three residues, Phe125, Arg127, and Tyr129, which determine NAT1-like substrate specificity in humans. These results support the conclusion that cytosolic arylamine N-acetylation activity is low in the cat because of the presence of a single N-acetyltransferase that has substrate specificity, immunogenicity and sequence characteristics similar to human NAT1, and that the unusual presence of only a single N- acetyltransferase gene appears to be a family wide trait shared by other felids. |
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0960-314x |
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Document Type: eng |
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Call Number |
SLN @ rana @ 345 |
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968 |
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Author |
Yanfa, L.; Huanwen, L. |
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A preliminary study on the rearing and breeding of ounce |
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Year |
1986 |
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Acta Theriologica Sinica |
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6 |
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2 |
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93-99 |
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captivity; husbandry; zoos; breeding; reproduction; mating; rearing; browse; 3710; Chinese |
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China |
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Document Type: Chinese |
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SLN @ rana @ 96 |
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1045 |
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Author |
Yu, N.Z.C.; Wang, X.; He, G.; Zhang, Z.; Zhang, A.; Lu, W.; Tang, F. |
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Title |
A revision of genus Uncia Gray, 1854 based on mitochondrial DNA restriction site maps |
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Journal Article |
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Year |
1996 |
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Acta Theriologica Sinica |
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16 |
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2 |
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105-108 |
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taxonomy; uncia; panthera; snow-leopard; snow leopard; browse; 1350; Chinese |
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The Snow leopard (Panthera uncia) is one of the most threatened wild big cats within its range of distribution, however, the question of its systematic status is a matter of debate. Is it a member of genus Panthera, or is it in its own genus (Uncia)? The analysis of genetic difference at the DNA level may provide useful data to clarify the issue. In the present study, ten hexanucleotide-specific restriction endonucleases were used to evaluate the patterns of mitochondrial DNA variation between the Snow leopard and leopard (P. pardus). The molecular size of mtDNA from the two species was about 16.5 kb. Ten enzymes surveyed 32-34 restriction sites, which corresponded to 192 apprx 204 base pairs, or 1.16% apprx 1.24% of the total mtDNA molecule. A total of 45 restriction sites were mapped; of these sites, twenty-four, which correspond to 53.3% of the total sites, were variable. The sequence divergence between them was 0.075 33, which was undoubtedly in the species-level distinction but did not reach the genus level. Therefore, the Snow leopard should be placed in the genus Panthera rather than in its own ganus. It also seems reasonable to recognize Uncia as a valid subgenus. This conclusion not only support but also supplement the viewpoint of Simpson who treated Uncia as a subgenus within Panthera. |
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Document Type: Chinese |
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SLN @ rana @ 295 |
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1063 |
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Lutz, H.; Hofmann-Lehmann, R.; Fehr, D.; Leutenegger, C.; Hartmann, M.; Ossent, P.; Grob, M.; Elgizoli, M.; Weilenmann, P. |
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Title |
Liberation of the wilderness of wild felids bred under human custody: Danger of release of viral infections |
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Journal Article |
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Year |
1996 |
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Schweizer Archiv fuer Tierheilkunde |
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Volume |
138 |
Issue |
12 |
Pages |
579-585 |
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Keywords |
endangered-species; European-Wild-Cat; Fiv; Fpv; Host; Human-Custody; infection; Pathogen; Reintroduction-Projects; Relocation-Projects; survival; Tibet; Veterinary-Medicine; Viral-Disease; Viral-Infection; Wild-Felid; Wild-Felid-Breeding; Wilderness-Liberation; Wildlife-Management; browse; endangered; species; european; wild; cat; Human; custody; reintroduction; project; relocation; veterinary; medicine; Viral; Disease; wild felid; breeding; wilderness; liberation; management; 690 |
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There are several felidae amongst the numerous endangered species. Means of aiding survival are the reintroduction to the wild of animals bred under the auspices of man and their relocation from densely populated to thinly populated areas. It is unlikely that the dangers of such reintroduction or relocation projects have been examined sufficiently in respect to the risks of virus infections confronting individuals kept in zoos or similar situations. This report presents infections may be expected to occur when relo- three examples to illustrate that accidental virus cating and reintroducing wild cats. The first example is the reintroduction of captive snow leopards. Zoo bred snow leopards may be infected with FIV, a virus infection that is highly unlikely to occur in the original hirnalayan highlands of Tibet and China. A second example is of several cases of FIP that occured in European wild cats bred in groups in captivity. The third example mentioned is the relocation of hons from East Africa where all the commonly known feline viruses are wide-spread to the Etosha National Park. In the latter, virus infections such as FIV, FCV and FPV do not occur. The indiscriminate relocation and reintroduction of the wild cats mentioned here harbours a potential of undesirable consequences. |
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Document Type: German |
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no |
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Call Number |
SLN @ rana @ 287 |
Serial |
629 |
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Author |
Chandra, S.; Laughlin, D.C. |
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Title |
Virus-like particles in cystic mammary adenoma of a snow leopard |
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Journal Article |
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Year |
1975 |
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Cancer Res |
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35 |
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11 Pt 1 |
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3069-3074 |
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Adenoma pathology veterinary; Animal; Animals; zoo; Carnivora; Cytoplasmic Granules; Endoplasmic Reticulum: ultrastructure; Inclusion Bodies; Mammae: pathology; Neoplasms: pathology: veterinary; neoplasms; pathology; mammae; inclusion; bodies; ultrastructure; reticulum; endoplasmic; granules; cytoplasmic; adenoma; veterinary; browse; 380 |
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Virus-like particles were observed in the giant cells of a mammary adenoma of a snow leopard kept in captivity. Particles that measured 115 to 125 nm in diameter budded from the lamella of endoplasmic reticulum and were studded on their inner surfaces with dense granules (approximately 12 nm) that gave them their unique ultrastructural morphology. Such particles were not observed extracellularly. Type B or type C particles were not seen in the tumor tissue. |
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0008-5472 |
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Document Type: eng |
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Call Number |
SLN @ rana @ 27 |
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212 |
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Paul, H.A.; Bargar, W.L.; Leininger, R. |
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Title |
Total hip replacement in a snow leopard |
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1985 |
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J Am Vet Med Assoc |
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187 |
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11 |
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1262-1263 |
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Animal; Carnivora; surgery; Case; Report; Hip; Dislocation; veterinary; Prosthesis; Male; browse; 310 |
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0003-1488 |
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Document Type: eng |
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SLN @ rana @ 82 |
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760 |
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Wharton, D. |
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Endangered Species Update |
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Journal Article |
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1997 |
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Endangered Species Update |
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14 |
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11 |
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13 |
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Species-Survival-Plan; zoo; breeders; captivity; Asa; Ssp; browse; species survival plan; species; survival; plan; 1100; endangered; endangered species; endangered-species |
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The snow leopard is listed as endangered, although most of its high mountain habitat remains untouched. However the ability of humans to exploit wildlife has led to it being endangered. Serious attempts to keep snow leopards in captivity began in 1891, but it was not until the 1950s that cubs survived long enough to become breeders. The American Zoo and Aquarium Association (ASA) Snow Leopard Species Survival Plan (SSP) was set up in 1984, achieving success with breeding goals. |
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Document Type: English |
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SLN @ rana @ 335 |
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1019 |
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Johnson, D. |
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The National Fish and Wildlife Foundation goes international |
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1994 |
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Endangered Species Update, A |
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11 |
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10 |
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A10 |
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Nfwf; India; asia; siberia; endangered-species; snow-leopard; managemnet; conservation; snow leopard; browse; endangered; species; 1150 |
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Abstract: The National Fish and Wildlife Foundation (NFWF) which is a conservation organization created in 1984 aims to conserve the species on an international context before they are endangered which will enable a more effective conservation procedure. The NFWF has addressed the causes of endangered species in India and South Asia such as the tiger, Indian wolf and the snow leopard and has supported the conservation efforts of the Siberian tiger. It has cooperated with multi-national organizations to evaluate the best strategy that could be adopted to prevent a future extinction of several species and has supported CITES programs |
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SLN @ rana @ 254 |
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500 |
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Reed-Smith, J.; Kumpf, M. |
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Title |
Snow leopards (Uncia uncia): family group management alternatives |
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1998 |
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Anim.Keepers' Forum |
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25 |
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10 |
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386-391 |
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behavior; captive-animal-care; endangered; threatened-species; intraspecies-relationships; mammals; techniques; zoos; snow leopard; husbandry; browse; captive; Animal; care; threatened; species; intraspecies; relationships; 1300 |
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The authors offer insights into creating family groups of snow leopards in zoos. The programs at the Denver Zoo, Denver, Colorado, and at John Ball Zoological Gardens, Grand Rapids, Michigan, are highlighted. lgh. |
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Document Type: English |
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SLN @ rana @ 340 |
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814 |
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Shafiq, M.M.; Abid, A. |
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Status of large mammal species in Khunjerab National Park |
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1998 |
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Pakistan Journal of Forestry |
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48 |
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1-4 |
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91-96 |
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Khunjerab-National-Park; large-mammals; endangered species; snow leopard; Uncia uncia; wolf; fox; ibex; sheep; bear; prey; predator; protected-area; Khunjerab; browse; national; park; large; mammals; endangered; species; uncia; protected; 560 |
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Study on the current status of large mammals species population was carried out in Khunjerab National Park, Northern Areas. The observation recorded showed that the population of Tibetan Red fox (Vulpes vulpes montana), Snow leopard (Uncia uncia), and Wolf (Canis lupus) have, though a bit, increased but are still in the rank of “Endangered”. While the population of Himalyan Ibex (Cpara ibex sibirica) is increasing more rapidly and their status is now “Common” in the Park. The limited population of Marcopolo sheep (Ovis ammon polii), Tibetan wild Ass (Equus hemionus kiang) and Brown bear (Urus arctos) is still under threat, and comes them under “Critical Endangered” category. |
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Document Type: English
Call Number: 634.909547 PA |
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SLN @ rana @ 342 |
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879 |
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