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Author Persianova L.A. url 
  Title About the Red Book listing rare and endangered animal and plant species Type Miscellaneous
  Year 1980 Publication Abbreviated Journal  
  Volume Issue Pages 41-42  
  Keywords Uzbekistan; Red Data book; flora; fauna; rare species; categories of threat; mammals; birds; reptiles; fishes; snow leopard.; 7870; Russian  
  Abstract The Red Book includes data of rare and endangered fauna and flora species. The species are sub-divided into five categories by threat. Volume 1 of the Red Book of the Uzbek SSR includes 22 mammal species, 31 bird species, five reptile and five fish species. Among them there are endemic species and species included in the International Red list. Snow leopard is referred to a category of endangered species.  
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  ISSN (down) http://www.snowleopard.org/islt/procite/lpabout80.doc ISBN Medium  
  Area Expedition Conference  
  Notes Full text available in RussianJournal Title: Urgent problems of nature protection and sustainable use of natural resources. Proceedings of the second national conference of Uzbekistan. Approved no  
  Call Number SLN @ rana @ 765 Serial 768  
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Author Roth, T.L.; Armstrong, D.L.; Barrie, M.T.; Wildt, D.E. url 
  Title Seasonal effects on ovarian responsiveness to exogenous gonadotrophins and successful artificial insemination in the snow leopard (Uncia uncia) Type Journal Article
  Year 1997 Publication Reprod Fertil Dev Abbreviated Journal  
  Volume 9 Issue 3 Pages 285-295  
  Keywords Animal; Carnivora; anatomy; histology; Blood; physiology; Estradiol; Female; Gonadotropins; administration; dosage; pharmacology; Chorionic; Equine; Human; Insemination; artificial; methods; veterinary; Laparoscopy; Male; Oocytes; cytology; Ovary; drug; effects; Ovulation; Induction; Pregnancy; Progesterone; Seasons; Support; Non-U.S.Gov't; browse; non; us; gov't; government; 400  
  Abstract Ovaries of the seasonally-breeding snow leopard (Uncia uncia) were examined to determine whether they were responsive to exogenous gonadotrophins throughout the year. The potential of laparoscopic artificial insemination (AI) also was assessed for producing offspring. During the non-breeding, pre-breeding, breeding and post-breeding seasons, females (n = 20) were treated with a standardized, dual- hormone regimen given intramuscularly (600 I.U. of equine chorionic gonadotrophin followed 80-84 h later with 300 I.U. of human chorionic gonadotrophin (hCG)). Laparoscopy was performed 45-50 h after administration of hCG, and all ovarian structures were described. Females with fresh corpora lutea (CL) were inseminated, and anovulatory females were subjected to follicular aspiration to examine oocyte quality. Snow leopards responded to exogenous gonadotrophins throughout the year. Mean number of total ovarian structures (distinct follicles mature in appearance plus CL) did not differ (P > or = 0.05) with season, but the proportion of CL: total ovarian structures was greater (P < 0.01) for the breeding season compared with all other seasons. The proportion of females ovulating was greater (P < 0.05) during the breeding and post-breeding seasons than during the pre-breeding and non- breeding seasons respectively. No Grade-1 quality oocytes were recovered from follicles of anovulatory females. Serum concentrations of oestradiol-17 beta appeared elevated in all females, and neither oestradiol-17 beta concentrations nor progesterone concentrations differed (P > or = 0.05) among seasons. Of 15 females artificially inseminated, the only one that was inseminated in the non-breeding season became pregnant and delivered a single cub. This is the first successful pregnancy resulting from AI in this endangered species.  
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  ISSN (down) 1031-3613 ISBN Medium  
  Area Expedition Conference  
  Notes Document Type: eng Approved no  
  Call Number SLN @ rana @ 325 Serial 830  
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Author Trepanier, L.A.; Cribb, A.E.; Spielberg, S.P.; Ray, K. url 
  Title Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene Type Journal Article
  Year 1998 Publication Pharmacogenetics Abbreviated Journal  
  Volume 8 Issue 2 Pages 169-179  
  Keywords Acetylation; Amino; Acid; Sequence; Animal; Arylamine; N-Acetyltransferase; metabolism; Base; Blotting; Southern; Carnivora; genetics; Cats; Cytosol; enzymology; Dna; Human; Isoenzymes; Liver; Molecular; Data; Polymerase; Chain; Reaction; Rabbits; Homology; Nucleic Acid; Substrate; Specificity; Support; U.S.Gov't; P.H.S.; browse; nucleic; us; government; 130  
  Abstract The purpose of this study was to determine the molecular basis for a relative deficiency in the cat of cytosolic arylamine N- acetyltransferase (NAT), an enzyme family that is important in the metabolism of xenobiotics and that normally consists of at least two related enzymes, NAT1 and NAT2. N-acetyltransferase in feline liver showed high affinity (mean Km = 2.1 microM) for p-aminobenzoic acid, an NAT1 selective substrate in humans and rabbits, but showed a very poor affinity (mean Km > 10 mM) for sulfamethazine, an NAT2 selective substrate in humans and rabbits. Immunoreactive N-acetyltransferase was detected in feline liver, bladder and colon using an NAT1-specific antipeptide antibody, but was not detected in any tissues using an NAT2- specific antibody. Southern blot analysis of genomic DNA demonstrated a single band in domestic cats using each of six restriction digests; single bands were also found on Southern blot analysis of six wild felids. The deduced amino acid sequence of the central portion of feline N-acetyltransferase, obtained by polymerase chain reaction amplification in both domestic cats and seven wild felids (lion, tiger, lynx, snow leopard, bobcat, Asian leopard cat and cheetah), contained three residues, Phe125, Arg127, and Tyr129, which determine NAT1-like substrate specificity in humans. These results support the conclusion that cytosolic arylamine N-acetylation activity is low in the cat because of the presence of a single N-acetyltransferase that has substrate specificity, immunogenicity and sequence characteristics similar to human NAT1, and that the unusual presence of only a single N- acetyltransferase gene appears to be a family wide trait shared by other felids.  
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  ISSN (down) 0960-314x ISBN Medium  
  Area Expedition Conference  
  Notes Document Type: eng Approved no  
  Call Number SLN @ rana @ 345 Serial 968  
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Author Gosselin, S.J.; Loudy, D.L.; Tarr, M.J.; Balistreri, W.F.; Setchell, K.D.; Johnston, J.O.; Kramer, L.W.; Dresser, B.L. url 
  Title Veno-occlusive disease of the liver in captive cheetah Type Journal Article
  Year 1988 Publication Vet Pathol Abbreviated Journal  
  Volume 25 Issue 1 Pages 48-57  
  Keywords Animal; Feed; analysis; Carnivora; Cheetahs; Female; Hepatic; Veno; Occlusive; Disease; pathology; veterinary; Histocytochemistry; Liver; ultrastructure; Male; Microscopy; Electron; Support; Non-U.S.Gov't; Vitamin A; browse; non; us; gov't; government; 280  
  Abstract Liver tissues from 126 captive cheetah were evaluated by light microscopy and histochemistry; eight animals were evaluated by electron microscopy. The main hepatic lesion, a vascular lesion resembling veno- occlusive disease (VOD) of the liver and characterized by subendothelial fibrosis and proliferation of smooth muscle-like cells in the central veins, was seen in 60% of the sexually mature cheetah. Although this hepatic vascular lesion was seen in cheetah as young as 1 year of age, the most severe lesions, usually associated with liver failure, were found in cheetah between the ages of 6 and 11. There was no sex predisposition, and in approximately 40% of the VOD cases, liver disease was not suspected clinically or at necropsy. VOD was found in other felidae, especially in the snow leopard. High levels of vitamin A in livers, as well as in diets of the cheetah, could be a contributing factor in the development of VOD in some groups of cheetah.  
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  ISSN (down) 0300-9858 ISBN Medium  
  Area Expedition Conference  
  Notes Document Type: Eng Approved no  
  Call Number SLN @ rana @ 127 Serial 339  
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Author Munson, L.; Worley, M.B. url 
  Title Veno-occlusive disease in snow leopards (Panthera uncia) from zoological parks Type Journal Article
  Year 1991 Publication Vet Pathol Abbreviated Journal  
  Volume 28 Issue 1 Pages 37-45  
  Keywords Cirrhosis; epidemiology; Hemosiderosis; Hepadnaviridae; Hepatic; Hepatitis; pathology; Veno-Occlusive; veterinary; zoo  
  Abstract Livers from 54 snow leopards, 4 days to 23 years old, that had died in 23 US zoos, were evaluated histopathologically to determine if the hepatic fibrosis, which has been noted to be prevalent in this species, was due to chronic active hepatitis from hepadnaviral infection, Ito cell proliferation, or hemosiderosis. Forty-two of 54 snow leopards had subintimal vascular fibrosis with partial or total occlusion of central and sublobular veins (veno-occlusive disease) of unknown origin. All 21 leopards older than 5 years were affected. Four leopards had chronic active hepatitis, and 12 leopards had cholangiohepatitis; but these lesions were not connected anatomically to central and sublobular venous fibrosis. Hepatocellular and Kupffer cell siderosis and Ito cell proliferation were prevalent and often coexisted with perisinusoidal, central, and sublobular venous fibrosis; but fibrosis was present in leopards without siderosis or Ito cell proliferation. The pattern and prevalence of veno-occlusive disease in these leopards was similar to that reported in captive cheetah (Acinonyx jubatus), suggesting that a common extrinsic factor may cause the majority of hepatic disease in these large felid animals in captivity.  
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  ISSN (down) 0300-9858 ISBN Medium  
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  Notes Document Type: eng Approved no  
  Call Number SLN @ rana @ 173 Serial 706  
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Author Sundberg, J.P.; Van Ranst, M.; Montali, R.; Homer, B.L.; Miller, W.H.; Rowland, P.H.; Scott, D.W.; England, J.J.; Dunstan, R.W.; Mikaelian, I.; Jenson, A.B. url 
  Title Feline papillomas and papillomaviruses Type Journal Article
  Year 2000 Publication Vet Pathol Abbreviated Journal  
  Volume 37 Issue 1 Pages 1-10  
  Keywords Animal; Antibodies; Monoclonal; Carnivora; pathology; virology; Cats; Dna; Viral; chemistry; Epitope; Mapping; veterinary; Female; Immunohistochemistry; Lions; Male; Microscopy; Electron; Papilloma; Papillomavirus; Papovaviridae; Infections; skin; neoplasms; Tongue; browse; 120  
  Abstract Papillomaviruses (PVs) are highly species- and site-specific pathogens of stratified squamous epithelium. Although PV infections in the various Felidae are rarely reported, we identified productive infections in six cat species. PV-induced proliferative skin or mucous membrane lesions were confirmed by immunohistochemical screening for papillomavirus-specific capsid antigens. Seven monoclonal antibodies, each of which reacts with an immunodominant antigenic determinant of the bovine papillomavirus L1 gene product, revealed that feline PV capsid epitopes were conserved to various degrees. This battery of monoclonal antibodies established differential expression patterns among cutaneous and oral PVs of snow leopards and domestic cats, suggesting that they represent distinct viruses. Clinically, the lesions in all species and anatomic sites were locally extensive and frequently multiple. Histologically, the areas of epidermal hyperplasia were flat with a similarity to benign tumors induced by cutaneotropic, carcinogenic PVs in immunosuppressed human patients. Limited restriction endonuclease analyses of viral genomic DNA confirmed the variability among three viral genomes recovered from available frozen tissue. Because most previous PV isolates have been species specific, these studies suggest that at least eight different cat papillomaviruses infect the oral cavity (tentative designations: Asian lion, Panthera leo, P1PV; snow leopard, Panthera uncia, PuPV-1; bobcat, Felis rufus, FrPV; Florida panther, Felis concolor, FcPV; clouded leopard, Neofelis nebulosa, NnPV; and domestic cat, Felis domesticus, FdPV-2) or skin (domestic cat, F. domesticus, FdPV-1; and snow leopard, P. uncia, PuPV-2).  
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  ISSN (down) 0300-9858 ISBN Medium  
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  Notes Document Type: eng Approved no  
  Call Number SLN @ rana @ 385 Serial 948  
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Author De Groot, H.; Van Swieten, P.; Aalberse, R.C. url 
  Title Evidence for a Fel d I-like molecule in the “big cats” (Felidae species) Type Journal Article
  Year 1990 Publication J Allergy Clin Immunol Abbreviated Journal  
  Volume 86 Issue 1 Pages 107-116  
  Keywords Adolescence; Adult; Allergens; immunology; Animal; Antibodies; Monoclonal; diagnostic; use; Antibody; Specificity; Carnivora; Cats; Comparative; study; Cross; Reactions; Hair; Histamine; Release; Human; IgE; analysis; IgG; Middle; Age; Radioallergosorbent; Test; methods; Support; Non-U.S.Gov't; browse; us; government; gov't; 240  
  Abstract In this study, we investigated the cross-reactivity pattern of IgE and IgG4 antibodies to the major feline allergen, Fel d I. We studied the IgE and IgG4 response of 11 cat-allergic patients against Fel d I-like structures in eight members of the Felidae family: ocelot, puma, serval, siberian tiger, lion, jaguar, snow leopard, and caracal. Hair from these “big cats” was collected, extracted, and used in a RAST system and histamine-release test. By means of a RAST-inhibition assay with affinity-purified Fel d I from cat dander, it was established that, in the Felidae species, a Fel d I equivalent is present that reacts with IgE and IgG4 antibodies. We found that all patients had cross-reacting IgE antibodies to seven of the Felidae tested; no IgE antibodies reactive with the caracal were found. Eight of 10 patients with IgG4 antibodies directed to cat dander also had IgG4 antibodies directed to several Felidae species, including the caracal. However, the correlation between the IgE and the IgG4 antibody specificity was low, indicating that, in the case of Fel d I IgE and IgG4, antibodies do not necessarily have the same specificity.  
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  ISSN (down) 0091-6749 ISBN Medium  
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  Notes Document Type: eng Approved no  
  Call Number SLN @ rana @ 157 Serial 233  
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Author Roth, T.L.; Howard, J.G.; Donoghue, A.M.; Swanson, W.F.; Wildt, D.E. url 
  Title Function and culture requirements of snow leopard (Panthera uncia) spermatozoa in vitro Type Journal Article
  Year 1994 Publication J Reprod Fertil Abbreviated Journal  
  Volume 101 Issue 3 Pages 563-569  
  Keywords Animal; Carnivora; physiology; Cell; survival; Cells; Cultured; Comparative; study; Culture; Media; Female; Male; Pentoxifylline; Sperm; Motility; Ovum; Interactions; Spermatozoa; cytology; Support; Non-U.S.Gov't; U.S.Gov't; P.H.S.; browse; non; us; gov't; government; 190  
  Abstract Electroejaculates from eight snow leopards were used to determine how the motility of spermatozoa was influenced by (i) type of media (Ham's F10, PBS, human tubal fluid or RPMI-1640); (ii) holding temperature (23 degrees C versus 37 degrees C); (iii) washing of spermatozoa and (iv) a sperm metabolic enhancer, pentoxifylline. The duration of sperm motility was assessed by evaluating samples in each treatment every hour for 6 h and a sperm motility index (a value combining percentage sperm motility and rate of forward progression) calculated. Spermatozoa from the Ham's F10, PBS and PBS plus pentoxifylline treatments were also co-incubated with zona-intact, domestic cat eggs that were fixed and evaluated for spermatozoa bound to the zona pellucida, penetrating the outer and inner layers of the zona pellucida and within the perivitelline space. During the 6 h co-incubation, the sperm motility index in PBS with pentoxifylline was greater (P < 0.05) than in PBS alone which, in turn, was greater (P < 0.05) than in the other three test media. Washing the spermatozoa enhanced (P < 0.05) motility in both PBS and PBS plus pentoxifylline relative to unwashed samples, but there was no effect (P > 0.05) of holding temperature. Pentoxifylline supplementation enhanced (P < 0.05) the proportion of cat eggs with bound, but not penetrated, snow leopard spermatozoa in the inner layer of the zona pellucida, and there were no spermatozoa in the perivitelline space.(ABSTRACT TRUNCATED AT 250 WORDS)  
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  ISSN (down) 0022-4251 ISBN Medium  
  Area Expedition Conference  
  Notes Document Type: eng Approved no  
  Call Number SLN @ rana @ 253 Serial 828  
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Author Schmidt, A.M.; Hess, D.L.; Schmidt, M.J.; Lewis, C.R. url 
  Title Serum concentrations of oestradiol and progesterone and frequency of sexual behaviour during the normal oestrous cycle in the snow leopard (Panthera uncia) Type Journal Article
  Year 1993 Publication J Reprod Fertil Abbreviated Journal  
  Volume 98 Issue 1 Pages 91-95  
  Keywords Animal; Animals; zoo; physiology; Carnivora; Estradiol; Blood; estrus; Female; Progesterone; Seasons; Sex; behavior; Support; U.S.Gov't; P.H.S.; browse; us; government; gov't; 490  
  Abstract Serum oestradiol and progesterone concentrations were measured at weekly intervals for six months, and correlated with daily behavioural observations in two adult female snow leopards (Panthera uncia). Three oestradiol peaks (> 21 pg ml-1; interval 3.6 weeks) were identified in a snow leopardess housed alone (two more were probably missed because of the weekly sampling schedule), and three oestradiol peaks were identified in a snow leopardess housed with a male as a breeding pair (interval 6 weeks). Daily frequencies of feline reproductive behaviour averaged 1.77 observations per observation period during weeks of high oestradiol and 0.62 during weeks of low oestradiol. Progesterone concentrations did not rise above baseline values (< 2 ng ml-1) in the isolated animal, but 6 weeks of high progesterone concentrations (4.9- 38.8 ng ml-1) was recorded in the paired snow leopardess following mating. No offspring were produced. Snow leopards were observed daily for an additional 4.5 years. Sexual behaviour peaks could be clearly identified from December through April, and average daily sexual behaviour scores were higher during these months than during the rest of the year. Intervals between sexual behaviour peaks for the isolated snow leopardess averaged 3.03 weeks. The sexual behaviour of the paired snow leopards decreased for 8-9 weeks following mating when no offspring were produced, and decreased for 13 weeks in one year when a single cub was born.  
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  ISSN (down) 0022-4251 ISBN Medium  
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  Notes Document Type: eng Approved no  
  Call Number SLN @ rana @ 204 Serial 874  
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Author Schmidt, R.E.; Eisenbrandt, D.L.; Hubbard, G.B. url 
  Title Tyzzer's disease in snow leopards Type Journal Article
  Year 1984 Publication J Comp Pathol Abbreviated Journal  
  Volume 94 Issue 1 Pages 165-167  
  Keywords Animal; Animals; Newborn; zoo; Bacillus; Bacterial; Infections; pathology; veterinary; Carnivora; Liver; browse; 330  
  Abstract Tyzzer's disease was diagnosed histologically in 2 litters of newborn snow leopard kittens. The gross and histological lesions were similar to those reported in domestic cats and other animals. No signs of illness was noted in either of the snow leopard dams.  
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  ISSN (down) 0021-9975 ISBN Medium  
  Area Expedition Conference  
  Notes Document Type: eng Approved no  
  Call Number SLN @ rana @ 67 Serial 875  
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