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Author |
Trepanier, L.A.; Cribb, A.E.; Spielberg, S.P.; Ray, K. |
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Title |
Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene |
Type |
Journal Article |
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Year |
1998 |
Publication |
Pharmacogenetics |
Abbreviated Journal |
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Volume |
8 |
Issue |
2 |
Pages |
169-179 |
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Keywords |
Acetylation; Amino; Acid; Sequence; Animal; Arylamine; N-Acetyltransferase; metabolism; Base; Blotting; Southern; Carnivora; genetics; Cats; Cytosol; enzymology; Dna; Human; Isoenzymes; Liver; Molecular; Data; Polymerase; Chain; Reaction; Rabbits; Homology; Nucleic Acid; Substrate; Specificity; Support; U.S.Gov't; P.H.S.; browse; nucleic; us; government; 130 |
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The purpose of this study was to determine the molecular basis for a relative deficiency in the cat of cytosolic arylamine N- acetyltransferase (NAT), an enzyme family that is important in the metabolism of xenobiotics and that normally consists of at least two related enzymes, NAT1 and NAT2. N-acetyltransferase in feline liver showed high affinity (mean Km = 2.1 microM) for p-aminobenzoic acid, an NAT1 selective substrate in humans and rabbits, but showed a very poor affinity (mean Km > 10 mM) for sulfamethazine, an NAT2 selective substrate in humans and rabbits. Immunoreactive N-acetyltransferase was detected in feline liver, bladder and colon using an NAT1-specific antipeptide antibody, but was not detected in any tissues using an NAT2- specific antibody. Southern blot analysis of genomic DNA demonstrated a single band in domestic cats using each of six restriction digests; single bands were also found on Southern blot analysis of six wild felids. The deduced amino acid sequence of the central portion of feline N-acetyltransferase, obtained by polymerase chain reaction amplification in both domestic cats and seven wild felids (lion, tiger, lynx, snow leopard, bobcat, Asian leopard cat and cheetah), contained three residues, Phe125, Arg127, and Tyr129, which determine NAT1-like substrate specificity in humans. These results support the conclusion that cytosolic arylamine N-acetylation activity is low in the cat because of the presence of a single N-acetyltransferase that has substrate specificity, immunogenicity and sequence characteristics similar to human NAT1, and that the unusual presence of only a single N- acetyltransferase gene appears to be a family wide trait shared by other felids. |
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0960-314x |
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Document Type: eng |
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Call Number |
SLN @ rana @ 345 |
Serial |
968 |
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Author |
Sundberg, J.P.; Van Ranst, M.; Montali, R.; Homer, B.L.; Miller, W.H.; Rowland, P.H.; Scott, D.W.; England, J.J.; Dunstan, R.W.; Mikaelian, I.; Jenson, A.B. |
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Title |
Feline papillomas and papillomaviruses |
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Journal Article |
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Year |
2000 |
Publication |
Vet Pathol |
Abbreviated Journal |
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Volume |
37 |
Issue |
1 |
Pages |
1-10 |
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Keywords |
Animal; Antibodies; Monoclonal; Carnivora; pathology; virology; Cats; Dna; Viral; chemistry; Epitope; Mapping; veterinary; Female; Immunohistochemistry; Lions; Male; Microscopy; Electron; Papilloma; Papillomavirus; Papovaviridae; Infections; skin; neoplasms; Tongue; browse; 120 |
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Abstract |
Papillomaviruses (PVs) are highly species- and site-specific pathogens of stratified squamous epithelium. Although PV infections in the various Felidae are rarely reported, we identified productive infections in six cat species. PV-induced proliferative skin or mucous membrane lesions were confirmed by immunohistochemical screening for papillomavirus-specific capsid antigens. Seven monoclonal antibodies, each of which reacts with an immunodominant antigenic determinant of the bovine papillomavirus L1 gene product, revealed that feline PV capsid epitopes were conserved to various degrees. This battery of monoclonal antibodies established differential expression patterns among cutaneous and oral PVs of snow leopards and domestic cats, suggesting that they represent distinct viruses. Clinically, the lesions in all species and anatomic sites were locally extensive and frequently multiple. Histologically, the areas of epidermal hyperplasia were flat with a similarity to benign tumors induced by cutaneotropic, carcinogenic PVs in immunosuppressed human patients. Limited restriction endonuclease analyses of viral genomic DNA confirmed the variability among three viral genomes recovered from available frozen tissue. Because most previous PV isolates have been species specific, these studies suggest that at least eight different cat papillomaviruses infect the oral cavity (tentative designations: Asian lion, Panthera leo, P1PV; snow leopard, Panthera uncia, PuPV-1; bobcat, Felis rufus, FrPV; Florida panther, Felis concolor, FcPV; clouded leopard, Neofelis nebulosa, NnPV; and domestic cat, Felis domesticus, FdPV-2) or skin (domestic cat, F. domesticus, FdPV-1; and snow leopard, P. uncia, PuPV-2). |
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0300-9858 |
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Document Type: eng |
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Call Number |
SLN @ rana @ 385 |
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948 |
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Author |
De Groot, H.; Van Swieten, P.; Aalberse, R.C. |
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Title |
Evidence for a Fel d I-like molecule in the “big cats” (Felidae species) |
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Journal Article |
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Year |
1990 |
Publication |
J Allergy Clin Immunol |
Abbreviated Journal |
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Volume |
86 |
Issue |
1 |
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107-116 |
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Keywords |
Adolescence; Adult; Allergens; immunology; Animal; Antibodies; Monoclonal; diagnostic; use; Antibody; Specificity; Carnivora; Cats; Comparative; study; Cross; Reactions; Hair; Histamine; Release; Human; IgE; analysis; IgG; Middle; Age; Radioallergosorbent; Test; methods; Support; Non-U.S.Gov't; browse; us; government; gov't; 240 |
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In this study, we investigated the cross-reactivity pattern of IgE and IgG4 antibodies to the major feline allergen, Fel d I. We studied the IgE and IgG4 response of 11 cat-allergic patients against Fel d I-like structures in eight members of the Felidae family: ocelot, puma, serval, siberian tiger, lion, jaguar, snow leopard, and caracal. Hair from these “big cats” was collected, extracted, and used in a RAST system and histamine-release test. By means of a RAST-inhibition assay with affinity-purified Fel d I from cat dander, it was established that, in the Felidae species, a Fel d I equivalent is present that reacts with IgE and IgG4 antibodies. We found that all patients had cross-reacting IgE antibodies to seven of the Felidae tested; no IgE antibodies reactive with the caracal were found. Eight of 10 patients with IgG4 antibodies directed to cat dander also had IgG4 antibodies directed to several Felidae species, including the caracal. However, the correlation between the IgE and the IgG4 antibody specificity was low, indicating that, in the case of Fel d I IgE and IgG4, antibodies do not necessarily have the same specificity. |
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0091-6749 |
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Document Type: eng |
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SLN @ rana @ 157 |
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233 |
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Author |
Hast, M.H. |
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Title |
The larynx of roaring and non-roaring cats |
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Journal Article |
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Year |
1989 |
Publication |
J Anat |
Abbreviated Journal |
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163 |
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117-121 |
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Animal; Carnivora; anatomy; histology; Cats; Comparative; study; Female; Larynx; physiology; Lions; Male; Vocal; Cords; vocalization; browse; 260 |
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Abstract |
Dissections were made of the larynges of 14 species of the cat family, with representative specimens from all genera. It was found that the vocal folds of the larynx of genus Panthera (with the exception of the snow leopard) form the basic structure of a sound generator well- designed to produce a high acoustical energy. Combined with an efficient sound radiator (vocal tract) that can be adjusted in length, a Panthera can use its vocal instrument literally to blow its own horn with a 'roar'. Also, it is proposed that laryngeal morphology can be used as an anatomical character in mammalian taxonomy. |
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0021-8782 |
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Document Type: eng |
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Call Number |
SLN @ rana @ 143 |
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374 |
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Author |
Macdonald, A.A.; Johnstone, M. |
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Title |
Comparative anatomy of the cardiac foramen ovale in cats (Felidae), dogs (Canidae), bears (Ursidae) and hyaenas (Hyaenidae) |
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Journal Article |
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Year |
1995 |
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J Anat |
Abbreviated Journal |
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Volume |
186 ( Pt 2) |
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235-243 |
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Animal; Newborn; Bears: anatomy & histology; Carnivora: anatomy & histology: embryology; Cats: anatomy & histology; Dogs: anatomy & histology; Heart Septum: anatomy & histology: embryology; Support,Non-U.S.Gov't; bear; anatomy; histology; Carnivora; embryology; Cats; cat; bears; Dog; Dogs; heart; septum; browse; non; gov't; us; government; 160 |
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The structure of the foramen ovale from 16 species representing 4 carnivore families, the Felidae, Canidae, Ursidae and Hyaenidae, was studied using the scanning electron microscope. The Felidae were represented by 9 domestic cat fetuses (Felis catus), 2 snow leopard neonates (Uncia uncia), an ocelot neonate (Leopardus pardalis), 2 lion neonates (Panthera leo), a panther neonate (Panthera pardus) and 3 tigers (Neofelis tigris), comprising 2 fetuses and a neonate. The Canidae were represented by a golden jackal neonate (Canis aureus), a newborn wolf (Canis lupus), 8 domestic dog fetuses (Canis familiaris), 3 red fox neonates (Vulpes vulpes) and a dhole neonate (Cuon alpinus). The Ursidae were represented by a brown bear neonate (Ursus arctos), a day-old grizzly bear cub (Ursus arctos horribilis), a polar bear neonate (Ursus maritimus), and 2 additional bear fetuses (species unknown). The Hyaenidae were represented by a striped hyaena neonate (Hyaena hyaena). In each species, the foramen ovale, when viewed from the terminal part of the caudal vena cava, had the appearance of a short tunnel. A thin fold of tissue, the developed remains of the embryonic septum primum, extended from the distal end of the caudal vena cava for a variable distance into the lumen of the left atrium and contributed towards the 'tunnel' appearance in all specimens. It constituted a large proportion of the tube, and its distal end was straight-edged. There was fibrous material underlying the endothelium of the flap, the apparent morphology of which suggested that it comprised cardiac muscle.(ABSTRACT TRUNCATED AT 250 WORDS) |
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0021-8782 |
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Document Type: eng |
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SLN @ rana @ 269 |
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632 |
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Kleinman, M.S.; Garman, R.H. |
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Title |
An endoscopic approach to a snow leopard |
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Journal Article |
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1978 |
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Gastroenterology |
Abbreviated Journal |
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74 |
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6 |
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1348 |
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Animal; Bezoars; veterinary; Carnivora; Cats; Esophagoscopy; Male; browse; 370 |
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0016-5085 |
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Document Type: eng |
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SLN @ rana @ 47 |
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536 |
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Author |
Brown, J.L.; Wasser, S.K.; Wildt, D.E.; Graham, L.H. |
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Title |
Comparative Aspects of Steroid Hormone Metabolism and Ovarian Activity in Felids, Measured Noninvasively in Feces |
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Journal Article |
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1994 |
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Biol Reprod |
Abbreviated Journal |
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51 |
Issue |
4 |
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776-786 |
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Animal; Carbon; Radioisotopes; Carnivora; Cats; Chromatography; High; Pressure; Liquid; Comparative Study; Estradiol; metabolism; Estrone; feces; chemistry; Female; Ovary; physiology; Pregnancy; Progesterone; Pseudopregnancy; Support; Non-U.S.Gov't; browse; non; government; gov't; us; 170 |
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Noninvasive fecal assays were used to study steroid metabolism and ovarian activity in several felid species. Using the domestic cat (Felis catus) as model, the excretory products of injected [14C]estradiol (E2) and [14C]progesterone (P4) were determined. Within 2 days, 97.0 +/- 0.6% and 96.7 +/- 0.5% of recovered E2 and P4 radioactivity, respectively, was found in feces. E2 was excreted as unconjugated estradiol and estrone (40%) and as a non-enzyme- hydrolyzable conjugate (60%). P4 was excreted primarily as non-enzyme- hydrolyzable, conjugated metabolites (78%) and as unconjugated pregnenolone epimers. A simple method for extracting fecal steroid metabolites optimized extraction efficiencies of the E2 and P4 excretion products (90.1 +/- 0.8% and 87.2 +/- 1.4%, respectively). Analysis of HPLC fractions of extracted fecal samples from the radiolabel-injected domestic cats revealed that E2 immunoreactivity coincided primarily with the unconjugated metabolized [14C]E2 peak, whereas progestogen immunoreactivity coincided with a single conjugated epimer and multiple unconjugated pregnenolone epimers. After HPLC separation, similar immunoreactive E2 and P4 metabolite profiles were observed in the leopard cat (F. bengalensis), cheetah (Acinonyx jubatus), clouded leopard (Neofelis nebulosa), and snow leopard (Panthera uncia). Longitudinal analyses demonstrated that changes in fecal E2 and P4 metabolite concentrations reflected natural or artificially induced ovarian activity. For example, severalfold increases in E2 excretion were associated with overt estrus or exogenous gonadotropin treatment, and elevated fecal P4 metabolite concentrations occurred during pregnant and nonpregnant (pseudopregnant) luteal phases. Although overall concentrations were similar, the duration of elevated fecal P4 metabolites during pseudopregnancy was approximately half that observed during pregnancy. In summary, steroid metabolism mechanisms appear to be conserved among these physically diverse, taxonomically related species. Results indicate that this hormone-monitoring approach will be extremely useful for elucidating the hormonal regulatory mechanism associated with the reproductive cycle, pregnancy, and parturition of intractable and endangered felid species. |
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0006-3363 |
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Document Type: eng |
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Call Number |
SLN @ rana @ 251 |
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198 |
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Author |
Lesnyak A.P. |
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Title |
Cats in Uzbekistan's fur trade |
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Miscellaneous |
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Year |
1984 |
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Abbreviated Journal |
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57-64 |
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Uzbekistan; rare species; Cats; species range; diet; hunting; pelts; poaching; snow leopard.; 7580; Russian |
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Abstract |
Data of distribution, food, and fur trade of Felidae (North Persian leopard, snow leopard, caracal, Turkestan lynx, manul, Turkestan steppe cat, jungle cat [chaus], sand cat) in Uzbekistan is given. Snow leopard is an object of illegal hunting. |
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Full text available in RussianJournal Title: Hunting and nature protection in Uzbekistan. |
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Call Number |
SLN @ rana @ 736 |
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615 |
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Author |
Ferretti, F., Lovari, S. |
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Title |
Predation may counteract climatic change as a driving force for movements of mountain ungulates |
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Report |
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2016 |
Publication |
Behavioural-Processes |
Abbreviated Journal |
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129 |
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101-104 |
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Climate change, Environmental change, Interspecific interactions, Large cats, Predator-prey interactions |
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Temperature variations are expected to influence altitudinal movements of mountain herbivores and, in
turn, those of their predators, but relevant information is scarce. We evaluated monthly relationships
between temperature and altitude used by a large mountain-dwelling herbivore, the Himalayan tahr
Hemitragus jemlahicus, and its main predator, the snow leopard Panthera uncia, in an area of central
Himalaya for five consecutive years (2006–2010). In contrast to expectations, there was no significant
direct relationship between altitude of tahr sightings and temperature. The mean altitude of tahr sightings
decreased by c. 200 m throughout our study. As expected, snow leopard movements tracked those of tahr,
although the core area of the snow leopard did not move downwards. Tahr remained the staple of the
snow leopard diet: we suggest that the former did not move upwards in reaction to higher temperature
to avoid encounters with the latter. Avoidance of competition with the larger common leopard Panthera
pardus at lower altitudes could explain why snow leopards did not shift their core area downwards.
Apparently, interspecific interactions (predation; competition) influenced movements of Himalayan tahr
and snow leopards more than climatic variations. |
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SLN @ rakhee @ |
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1441 |
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Author |
Zakirov A. |
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Title |
Cats |
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Miscellaneous |
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1974 |
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Abbreviated Journal |
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196-198 |
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Uzbekistan; Ferghana valley; mammals; Cats; snow leopard; distribution.; 8680; Russian |
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Abstract |
It describes a fauna complex of the Fergana valley in Uzbekistan. Three cat family species are found there (wild cat, Turkistan lynx and snow leopard). Snow leopard (Uncia uncia) inhabits eastern part of the Chatkal ridge in the mountains of Akchala. Known are cases of snow leopard's preying on sheep in summer but such cases are extremely rare and the harm is negligent. This is a highly endangered species and therefore full prohibition of shooting the animals is required. |
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Full text available in RussianJournal Title: Vertebrates in the Ferghana valley. |
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Call Number |
SLN @ rana @ 845 |
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1070 |
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