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Author Kolmstetter, C.; Munson, L.; Ramsay, E.C.
Title Degenerative spinal disease in large felids Type Journal Article
Year 2000 Publication J Zoo Wildl Med Abbreviated Journal
Volume 31 Issue 1 Pages 15-19
Keywords Age-Factors; Animal; Animals; zoo; Autopsy; veterinary; Carnivora; Female; Lions; Male; Age; factor; browse; 110
Abstract Degenerative spinal disorders, including intervertebral disc disease and spondylosis, seldom occur in domestic cats. In contrast, a retrospective study of 13 lions (Panthera leo), 16 tigers (Panthera tigris), 4 leopards (Panthera pardis), 1 snow leopard (Panthera uncia), and 3 jaguars (Panthera onca) from the Knoxville Zoo that died or were euthanatized from 1976 to 1996 indicated that degenerative spinal disease is an important problem in large nondomestic felids. The medical record, radiographic data, and the necropsy report of each animal were examined for evidence of intervertebral disc disease or spondylosis. Eight (three lions, four tigers, and one leopard) animals were diagnosed with degenerative spinal disease. Clinical signs included progressively decreased activity, moderate to severe rear limb muscle atrophy, chronic intermittent rear limb paresis, and ataxia. The age at onset of clinical signs was 10-19 yr (median = 18 yr). Radiographic evaluation of the spinal column was useful in assessing the severity of spinal lesions, and results were correlated with necropsy findings. Lesions were frequently multifocal, included intervertebral disc mineralization or herniation with collapsed intervertebral disc spaces, and were most common in the lumbar area but also involved cervical and thoracic vertebrae. Marked spondylosis was present in the cats with intervertebral disc disease, presumably subsequent to vertebral instability. Six of the animals' spinal cords were examined histologically, and five had acute or chronic damage to the spinal cord secondary to disc protrusion. Spinal disease should be suspected in geriatric large felids with decreased appetite or activity. Radiographic evaluation of the spinal column is the most useful method to assess the type and severity of spinal lesions.
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ISSN (down) 1042-7260 ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 384 Serial 545
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Author Roth, T.L.; Armstrong, D.L.; Barrie, M.T.; Wildt, D.E.
Title Seasonal effects on ovarian responsiveness to exogenous gonadotrophins and successful artificial insemination in the snow leopard (Uncia uncia) Type Journal Article
Year 1997 Publication Reprod Fertil Dev Abbreviated Journal
Volume 9 Issue 3 Pages 285-295
Keywords Animal; Carnivora; anatomy; histology; Blood; physiology; Estradiol; Female; Gonadotropins; administration; dosage; pharmacology; Chorionic; Equine; Human; Insemination; artificial; methods; veterinary; Laparoscopy; Male; Oocytes; cytology; Ovary; drug; effects; Ovulation; Induction; Pregnancy; Progesterone; Seasons; Support; Non-U.S.Gov't; browse; non; us; gov't; government; 400
Abstract Ovaries of the seasonally-breeding snow leopard (Uncia uncia) were examined to determine whether they were responsive to exogenous gonadotrophins throughout the year. The potential of laparoscopic artificial insemination (AI) also was assessed for producing offspring. During the non-breeding, pre-breeding, breeding and post-breeding seasons, females (n = 20) were treated with a standardized, dual- hormone regimen given intramuscularly (600 I.U. of equine chorionic gonadotrophin followed 80-84 h later with 300 I.U. of human chorionic gonadotrophin (hCG)). Laparoscopy was performed 45-50 h after administration of hCG, and all ovarian structures were described. Females with fresh corpora lutea (CL) were inseminated, and anovulatory females were subjected to follicular aspiration to examine oocyte quality. Snow leopards responded to exogenous gonadotrophins throughout the year. Mean number of total ovarian structures (distinct follicles mature in appearance plus CL) did not differ (P > or = 0.05) with season, but the proportion of CL: total ovarian structures was greater (P < 0.01) for the breeding season compared with all other seasons. The proportion of females ovulating was greater (P < 0.05) during the breeding and post-breeding seasons than during the pre-breeding and non- breeding seasons respectively. No Grade-1 quality oocytes were recovered from follicles of anovulatory females. Serum concentrations of oestradiol-17 beta appeared elevated in all females, and neither oestradiol-17 beta concentrations nor progesterone concentrations differed (P > or = 0.05) among seasons. Of 15 females artificially inseminated, the only one that was inseminated in the non-breeding season became pregnant and delivered a single cub. This is the first successful pregnancy resulting from AI in this endangered species.
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ISSN (down) 1031-3613 ISBN Medium
Area Expedition Conference
Notes Document Type: eng Approved no
Call Number SLN @ rana @ 325 Serial 830
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Author Trepanier, L.A.; Cribb, A.E.; Spielberg, S.P.; Ray, K.
Title Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene Type Journal Article
Year 1998 Publication Pharmacogenetics Abbreviated Journal
Volume 8 Issue 2 Pages 169-179
Keywords Acetylation; Amino; Acid; Sequence; Animal; Arylamine; N-Acetyltransferase; metabolism; Base; Blotting; Southern; Carnivora; genetics; Cats; Cytosol; enzymology; Dna; Human; Isoenzymes; Liver; Molecular; Data; Polymerase; Chain; Reaction; Rabbits; Homology; Nucleic Acid; Substrate; Specificity; Support; U.S.Gov't; P.H.S.; browse; nucleic; us; government; 130
Abstract The purpose of this study was to determine the molecular basis for a relative deficiency in the cat of cytosolic arylamine N- acetyltransferase (NAT), an enzyme family that is important in the metabolism of xenobiotics and that normally consists of at least two related enzymes, NAT1 and NAT2. N-acetyltransferase in feline liver showed high affinity (mean Km = 2.1 microM) for p-aminobenzoic acid, an NAT1 selective substrate in humans and rabbits, but showed a very poor affinity (mean Km > 10 mM) for sulfamethazine, an NAT2 selective substrate in humans and rabbits. Immunoreactive N-acetyltransferase was detected in feline liver, bladder and colon using an NAT1-specific antipeptide antibody, but was not detected in any tissues using an NAT2- specific antibody. Southern blot analysis of genomic DNA demonstrated a single band in domestic cats using each of six restriction digests; single bands were also found on Southern blot analysis of six wild felids. The deduced amino acid sequence of the central portion of feline N-acetyltransferase, obtained by polymerase chain reaction amplification in both domestic cats and seven wild felids (lion, tiger, lynx, snow leopard, bobcat, Asian leopard cat and cheetah), contained three residues, Phe125, Arg127, and Tyr129, which determine NAT1-like substrate specificity in humans. These results support the conclusion that cytosolic arylamine N-acetylation activity is low in the cat because of the presence of a single N-acetyltransferase that has substrate specificity, immunogenicity and sequence characteristics similar to human NAT1, and that the unusual presence of only a single N- acetyltransferase gene appears to be a family wide trait shared by other felids.
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ISSN (down) 0960-314x ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 345 Serial 968
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Author Thorel, M.F.; Karoui, C.; Varnerot, A.; Fleury, C.; Vincent, V.
Title Isolation of Mycobacterium bovis from baboons, leopards and a sea-lion Type Journal Article
Year 1998 Publication Vet Res Abbreviated Journal
Volume 29 Issue 2 Pages 207-212
Keywords Animal; Animals; zoo; Carnivora; microbiology; Case; Report; Cattle; Dna; Fingerprinting; Transposable; Elements; Disease; Outbreaks; veterinary; France; Genome; Bacterial; Germany; Male; Monkey; Diseases; diagnosis; epidemiology; Mycobacterium; Infections; bovis; classification; isolation; purification; Papio; Seals; browse; 440
Abstract This study reports on two series of cases of Mycobacterium bovis infection in zoo animals. The first was in a captive population of baboons (Papio hamadryas) and the second in a mixed group of wild mammals, including four leopards (Panthera uncia and Panthera pardus) and a sea-lion (Otaria byrona). The isolation and identification of strains of M. bovis confirmed the presence of M. bovis infections in both zoos. The epidemiological study using genetic markers such as the IS6110-based DNA fingerprinting system made it possible to differentiate between M. bovis strains. The M. bovis strains isolated from baboons were shown to contain a single IS6110 copy, as usually do cattle isolates, whereas the M. bovis strains isolated from the other exotic animals presented multiple copies. This finding suggests that the origin of the contamination for the baboons in zoo A could be related to cattle. The origin of the contamination for the leopards and sea-lion in zoo B is more difficult to determine. In conclusion, the authors suggest some recommendations for avoiding outbreaks of tuberculosis infections in zoos.
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ISSN (down) 0928-4249 ISBN Medium
Area Expedition Conference
Notes Document Type: eng Approved no
Call Number SLN @ rana @ 346 Serial 966
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Author Hochstrasser, K.; Wachter, E.; Reisinger, P.W.; Greim, M.; Albrecht, G.J.; Gebhard, W.
Title Amino acid sequences of mammalian kazal-type proteinase inhibitors from salivary glands Type Journal Article
Year 1993 Publication Comp Biochem Physiol B Abbreviated Journal
Volume 106 Issue 1 Pages 103-108
Keywords Amino; Acid; Sequence; Animal; Carnivora; Comparative; study; Cysteine; chemistry; Glycosylation; Mink; Molecular; Data; Protease; Inhibitors; Salivary; Proteins; species; Specificity; Submandibular; Gland; Trypsin; Inhibitor; Kazal; Pancreatic; browse; 200
Abstract 1. The amino acid sequences of bikazins (the double-headed Kazal-type proteinase inhibitors from submandibular glands) isolated from the snow leopard (Unica unica), the European mink (Mustela lutreola), and the European pine marten (Martes martes) were determined. 2. N-terminal domains of bikazins are characterized by a cysteine residue spacing that differs from that of C-terminal domains of bikazins and other Kazal-type proteinase inhibitor domains. 3. N-terminal sequences of bikazins seem to be specific for, and highly conserved within, each Carnivora family.
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Series Editor Series Title Abbreviated Series Title
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ISSN (down) 0305-0491 ISBN Medium
Area Expedition Conference
Notes Document Type: eng Approved no
Call Number SLN @ rana @ 202 Serial 385
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Author Schaffer, E.; Wiesner, H.; Von Hegel, G.
Title Multiple ocular coloboma (MOC) with persistent pupillary membrane in the snow leopard (Panthera uncia) Type Journal Article
Year 1988 Publication Tierarztl Prax Abbreviated Journal
Volume 16 Issue 1 Pages 87-91
Keywords Animal; Carnivora; Case; Report; Coloboma; etiology; pathology; veterinary; Comparative; study; Eyelids; abnormalities; Male; Optic; Nerve; Syndrome; browse; 270; german
Abstract In a litter of three snow leopards, bilateral colobomata of the upper temporal eyelids, bilateral persistent pupillary membranes and a unilateral coloboma of the optic nerve entrance are described as “Multiple Ocular Colobomata” (MOC). The causal pathogenesis of each of the colobomata is discussed comparatively. The colobomata of the eyelids, essential feature of the MOC syndrome in snow leopards, are most probably not of hereditary, but rather of intrauterine infectious viral origin.
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ISSN (down) 0303-6286 ISBN Medium
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Notes Document Type: German Approved no
Call Number SLN @ rana @ 112 Serial 851
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Author Gosselin, S.J.; Loudy, D.L.; Tarr, M.J.; Balistreri, W.F.; Setchell, K.D.; Johnston, J.O.; Kramer, L.W.; Dresser, B.L.
Title Veno-occlusive disease of the liver in captive cheetah Type Journal Article
Year 1988 Publication Vet Pathol Abbreviated Journal
Volume 25 Issue 1 Pages 48-57
Keywords Animal; Feed; analysis; Carnivora; Cheetahs; Female; Hepatic; Veno; Occlusive; Disease; pathology; veterinary; Histocytochemistry; Liver; ultrastructure; Male; Microscopy; Electron; Support; Non-U.S.Gov't; Vitamin A; browse; non; us; gov't; government; 280
Abstract Liver tissues from 126 captive cheetah were evaluated by light microscopy and histochemistry; eight animals were evaluated by electron microscopy. The main hepatic lesion, a vascular lesion resembling veno- occlusive disease (VOD) of the liver and characterized by subendothelial fibrosis and proliferation of smooth muscle-like cells in the central veins, was seen in 60% of the sexually mature cheetah. Although this hepatic vascular lesion was seen in cheetah as young as 1 year of age, the most severe lesions, usually associated with liver failure, were found in cheetah between the ages of 6 and 11. There was no sex predisposition, and in approximately 40% of the VOD cases, liver disease was not suspected clinically or at necropsy. VOD was found in other felidae, especially in the snow leopard. High levels of vitamin A in livers, as well as in diets of the cheetah, could be a contributing factor in the development of VOD in some groups of cheetah.
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ISSN (down) 0300-9858 ISBN Medium
Area Expedition Conference
Notes Document Type: Eng Approved no
Call Number SLN @ rana @ 127 Serial 339
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Author Sundberg, J.P.; Van Ranst, M.; Montali, R.; Homer, B.L.; Miller, W.H.; Rowland, P.H.; Scott, D.W.; England, J.J.; Dunstan, R.W.; Mikaelian, I.; Jenson, A.B.
Title Feline papillomas and papillomaviruses Type Journal Article
Year 2000 Publication Vet Pathol Abbreviated Journal
Volume 37 Issue 1 Pages 1-10
Keywords Animal; Antibodies; Monoclonal; Carnivora; pathology; virology; Cats; Dna; Viral; chemistry; Epitope; Mapping; veterinary; Female; Immunohistochemistry; Lions; Male; Microscopy; Electron; Papilloma; Papillomavirus; Papovaviridae; Infections; skin; neoplasms; Tongue; browse; 120
Abstract Papillomaviruses (PVs) are highly species- and site-specific pathogens of stratified squamous epithelium. Although PV infections in the various Felidae are rarely reported, we identified productive infections in six cat species. PV-induced proliferative skin or mucous membrane lesions were confirmed by immunohistochemical screening for papillomavirus-specific capsid antigens. Seven monoclonal antibodies, each of which reacts with an immunodominant antigenic determinant of the bovine papillomavirus L1 gene product, revealed that feline PV capsid epitopes were conserved to various degrees. This battery of monoclonal antibodies established differential expression patterns among cutaneous and oral PVs of snow leopards and domestic cats, suggesting that they represent distinct viruses. Clinically, the lesions in all species and anatomic sites were locally extensive and frequently multiple. Histologically, the areas of epidermal hyperplasia were flat with a similarity to benign tumors induced by cutaneotropic, carcinogenic PVs in immunosuppressed human patients. Limited restriction endonuclease analyses of viral genomic DNA confirmed the variability among three viral genomes recovered from available frozen tissue. Because most previous PV isolates have been species specific, these studies suggest that at least eight different cat papillomaviruses infect the oral cavity (tentative designations: Asian lion, Panthera leo, P1PV; snow leopard, Panthera uncia, PuPV-1; bobcat, Felis rufus, FrPV; Florida panther, Felis concolor, FcPV; clouded leopard, Neofelis nebulosa, NnPV; and domestic cat, Felis domesticus, FdPV-2) or skin (domestic cat, F. domesticus, FdPV-1; and snow leopard, P. uncia, PuPV-2).
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ISSN (down) 0300-9858 ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 385 Serial 948
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Author De Groot, H.; Van Swieten, P.; Aalberse, R.C.
Title Evidence for a Fel d I-like molecule in the “big cats” (Felidae species) Type Journal Article
Year 1990 Publication J Allergy Clin Immunol Abbreviated Journal
Volume 86 Issue 1 Pages 107-116
Keywords Adolescence; Adult; Allergens; immunology; Animal; Antibodies; Monoclonal; diagnostic; use; Antibody; Specificity; Carnivora; Cats; Comparative; study; Cross; Reactions; Hair; Histamine; Release; Human; IgE; analysis; IgG; Middle; Age; Radioallergosorbent; Test; methods; Support; Non-U.S.Gov't; browse; us; government; gov't; 240
Abstract In this study, we investigated the cross-reactivity pattern of IgE and IgG4 antibodies to the major feline allergen, Fel d I. We studied the IgE and IgG4 response of 11 cat-allergic patients against Fel d I-like structures in eight members of the Felidae family: ocelot, puma, serval, siberian tiger, lion, jaguar, snow leopard, and caracal. Hair from these “big cats” was collected, extracted, and used in a RAST system and histamine-release test. By means of a RAST-inhibition assay with affinity-purified Fel d I from cat dander, it was established that, in the Felidae species, a Fel d I equivalent is present that reacts with IgE and IgG4 antibodies. We found that all patients had cross-reacting IgE antibodies to seven of the Felidae tested; no IgE antibodies reactive with the caracal were found. Eight of 10 patients with IgG4 antibodies directed to cat dander also had IgG4 antibodies directed to several Felidae species, including the caracal. However, the correlation between the IgE and the IgG4 antibody specificity was low, indicating that, in the case of Fel d I IgE and IgG4, antibodies do not necessarily have the same specificity.
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ISSN (down) 0091-6749 ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 157 Serial 233
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Author Chaudhuri, S.; Mukherjee, S.K.; Chatterjee, A.; Ganguli, J.L.
Title Isolation of P multocida F-3, 4 from a stillborn snow leopard Type Journal Article
Year 1992 Publication Vet Rec Abbreviated Journal
Volume 130 Issue 2 Pages 36
Keywords Animal; Bacteremia; Blood; browse; Carnivora; Death; Diseases; Female; Fetal; Infections; isolation; microbiology; multocida; Pasteurella; Pregnancy; purification; veterinary
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ISSN (down) 0042-4900 ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 187 Serial 214
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Author Roth, T.L.; Howard, J.G.; Donoghue, A.M.; Swanson, W.F.; Wildt, D.E.
Title Function and culture requirements of snow leopard (Panthera uncia) spermatozoa in vitro Type Journal Article
Year 1994 Publication J Reprod Fertil Abbreviated Journal
Volume 101 Issue 3 Pages 563-569
Keywords Animal; Carnivora; physiology; Cell; survival; Cells; Cultured; Comparative; study; Culture; Media; Female; Male; Pentoxifylline; Sperm; Motility; Ovum; Interactions; Spermatozoa; cytology; Support; Non-U.S.Gov't; U.S.Gov't; P.H.S.; browse; non; us; gov't; government; 190
Abstract Electroejaculates from eight snow leopards were used to determine how the motility of spermatozoa was influenced by (i) type of media (Ham's F10, PBS, human tubal fluid or RPMI-1640); (ii) holding temperature (23 degrees C versus 37 degrees C); (iii) washing of spermatozoa and (iv) a sperm metabolic enhancer, pentoxifylline. The duration of sperm motility was assessed by evaluating samples in each treatment every hour for 6 h and a sperm motility index (a value combining percentage sperm motility and rate of forward progression) calculated. Spermatozoa from the Ham's F10, PBS and PBS plus pentoxifylline treatments were also co-incubated with zona-intact, domestic cat eggs that were fixed and evaluated for spermatozoa bound to the zona pellucida, penetrating the outer and inner layers of the zona pellucida and within the perivitelline space. During the 6 h co-incubation, the sperm motility index in PBS with pentoxifylline was greater (P < 0.05) than in PBS alone which, in turn, was greater (P < 0.05) than in the other three test media. Washing the spermatozoa enhanced (P < 0.05) motility in both PBS and PBS plus pentoxifylline relative to unwashed samples, but there was no effect (P > 0.05) of holding temperature. Pentoxifylline supplementation enhanced (P < 0.05) the proportion of cat eggs with bound, but not penetrated, snow leopard spermatozoa in the inner layer of the zona pellucida, and there were no spermatozoa in the perivitelline space.(ABSTRACT TRUNCATED AT 250 WORDS)
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Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (down) 0022-4251 ISBN Medium
Area Expedition Conference
Notes Document Type: eng Approved no
Call Number SLN @ rana @ 253 Serial 828
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Author Schmidt, A.M.; Hess, D.L.; Schmidt, M.J.; Lewis, C.R.
Title Serum concentrations of oestradiol and progesterone and frequency of sexual behaviour during the normal oestrous cycle in the snow leopard (Panthera uncia) Type Journal Article
Year 1993 Publication J Reprod Fertil Abbreviated Journal
Volume 98 Issue 1 Pages 91-95
Keywords Animal; Animals; zoo; physiology; Carnivora; Estradiol; Blood; estrus; Female; Progesterone; Seasons; Sex; behavior; Support; U.S.Gov't; P.H.S.; browse; us; government; gov't; 490
Abstract Serum oestradiol and progesterone concentrations were measured at weekly intervals for six months, and correlated with daily behavioural observations in two adult female snow leopards (Panthera uncia). Three oestradiol peaks (> 21 pg ml-1; interval 3.6 weeks) were identified in a snow leopardess housed alone (two more were probably missed because of the weekly sampling schedule), and three oestradiol peaks were identified in a snow leopardess housed with a male as a breeding pair (interval 6 weeks). Daily frequencies of feline reproductive behaviour averaged 1.77 observations per observation period during weeks of high oestradiol and 0.62 during weeks of low oestradiol. Progesterone concentrations did not rise above baseline values (< 2 ng ml-1) in the isolated animal, but 6 weeks of high progesterone concentrations (4.9- 38.8 ng ml-1) was recorded in the paired snow leopardess following mating. No offspring were produced. Snow leopards were observed daily for an additional 4.5 years. Sexual behaviour peaks could be clearly identified from December through April, and average daily sexual behaviour scores were higher during these months than during the rest of the year. Intervals between sexual behaviour peaks for the isolated snow leopardess averaged 3.03 weeks. The sexual behaviour of the paired snow leopards decreased for 8-9 weeks following mating when no offspring were produced, and decreased for 13 weeks in one year when a single cub was born.
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ISSN (down) 0022-4251 ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 204 Serial 874
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Author Johnston, L.A.; Armstrong, D.L.; Brown, J.L.
Title Seasonal effects on seminal and endocrine traits in the captive snow leopard (Panthera uncia) Type Journal Article
Year 1994 Publication J Reprod Fertil Abbreviated Journal
Volume 102 Issue 1 Pages 229-236
Keywords Animal; Carnivora; physiology; Comparative; study; Fsh; Blood; Gonadotropins; Pituitary; Lh; Male; Seasons; Semen; Sperm; Motility; Spermatozoa; cytology; Testosterone; browse; 180
Abstract The annual reproductive cycle of the male snow leopard (Panthera uncia) was characterized by evaluating seminal and endocrine traits monthly. Testicular volume was greatest (P < 0.05) during the winter months when the quality of ejaculate was optimal. Ejaculate volume, total sperm concentration ml-1, motile sperm concentration per ejaculate, sperm morphology and sperm motility index were lowest during the summer and autumn months compared with the winter and spring. Peripheral LH, FSH and testosterone concentrations were also lowest during the summer months, increasing during the autumn just before the increase in semen quality, and were maximal during the winter months. There was a direct relationship (P < 0.01) between: (1) testosterone and testicular volume, total sperm concentration ml-1, motile sperm concentration per ejaculate and ejaculate volume, and (2) LH and testicular volume and motile sperm concentration per ejaculate. In summary, although spermatozoa were recovered throughout the year, optimal gamete quality was observed during the winter and spring. Although previous studies in felids have demonstrated seasonal effects on either seminal or endocrine traits, this is the first study to demonstrate a distinct effect of season on both pituitary and testicular function.
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ISSN (down) 0022-4251 ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 252 Serial 504
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Author Doster, A.R.; Armstrong, D.L.; Bargar, T.W.
Title Seminoma and parathyroid adenoma in a snow leopard (Panthera unica) Type Journal Article
Year 1989 Publication J Comp Pathol Abbreviated Journal
Volume 100 Issue 4 Pages 475-480
Keywords Adenoma: pathology: veterinary; Animal; Carnivora; Dysgerminoma; pathology; veterinary; Male; Microscopy; Electron; neoplasms; Multiple Primary; Parathyroid; Testicular Neoplasms; adenoma; multiple; primary; Testicular; browse; 250
Abstract A seminoma and parathyroid adenoma were diagnosed in an aged snow leopard. The ultrastructural appearance of the seminoma was similar to that described in the dog and in man. The lack of significant amounts of rough endoplasmic reticulum, Golgi complexes and free ribosomes in the parathyroid adenoma suggested that it was non-functional. Parathyroid adenoma has not been previously described in a large wild feline.
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Series Editor Series Title Abbreviated Series Title
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ISSN (down) 0021-9975 ISBN Medium
Area Expedition Conference
Notes Document Type: eng Approved no
Call Number SLN @ rana @ 142 Serial 244
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Author Schmidt, R.E.; Eisenbrandt, D.L.; Hubbard, G.B.
Title Tyzzer's disease in snow leopards Type Journal Article
Year 1984 Publication J Comp Pathol Abbreviated Journal
Volume 94 Issue 1 Pages 165-167
Keywords Animal; Animals; Newborn; zoo; Bacillus; Bacterial; Infections; pathology; veterinary; Carnivora; Liver; browse; 330
Abstract Tyzzer's disease was diagnosed histologically in 2 litters of newborn snow leopard kittens. The gross and histological lesions were similar to those reported in domestic cats and other animals. No signs of illness was noted in either of the snow leopard dams.
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ISSN (down) 0021-9975 ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 67 Serial 875
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Author Hast, M.H.
Title The larynx of roaring and non-roaring cats Type Journal Article
Year 1989 Publication J Anat Abbreviated Journal
Volume 163 Issue Pages 117-121
Keywords Animal; Carnivora; anatomy; histology; Cats; Comparative; study; Female; Larynx; physiology; Lions; Male; Vocal; Cords; vocalization; browse; 260
Abstract Dissections were made of the larynges of 14 species of the cat family, with representative specimens from all genera. It was found that the vocal folds of the larynx of genus Panthera (with the exception of the snow leopard) form the basic structure of a sound generator well- designed to produce a high acoustical energy. Combined with an efficient sound radiator (vocal tract) that can be adjusted in length, a Panthera can use its vocal instrument literally to blow its own horn with a 'roar'. Also, it is proposed that laryngeal morphology can be used as an anatomical character in mammalian taxonomy.
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ISSN (down) 0021-8782 ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 143 Serial 374
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Author Macdonald, A.A.; Johnstone, M.
Title Comparative anatomy of the cardiac foramen ovale in cats (Felidae), dogs (Canidae), bears (Ursidae) and hyaenas (Hyaenidae) Type Journal Article
Year 1995 Publication J Anat Abbreviated Journal
Volume 186 ( Pt 2) Issue Pages 235-243
Keywords Animal; Newborn; Bears: anatomy & histology; Carnivora: anatomy & histology: embryology; Cats: anatomy & histology; Dogs: anatomy & histology; Heart Septum: anatomy & histology: embryology; Support,Non-U.S.Gov't; bear; anatomy; histology; Carnivora; embryology; Cats; cat; bears; Dog; Dogs; heart; septum; browse; non; gov't; us; government; 160
Abstract The structure of the foramen ovale from 16 species representing 4 carnivore families, the Felidae, Canidae, Ursidae and Hyaenidae, was studied using the scanning electron microscope. The Felidae were represented by 9 domestic cat fetuses (Felis catus), 2 snow leopard neonates (Uncia uncia), an ocelot neonate (Leopardus pardalis), 2 lion neonates (Panthera leo), a panther neonate (Panthera pardus) and 3 tigers (Neofelis tigris), comprising 2 fetuses and a neonate. The Canidae were represented by a golden jackal neonate (Canis aureus), a newborn wolf (Canis lupus), 8 domestic dog fetuses (Canis familiaris), 3 red fox neonates (Vulpes vulpes) and a dhole neonate (Cuon alpinus). The Ursidae were represented by a brown bear neonate (Ursus arctos), a day-old grizzly bear cub (Ursus arctos horribilis), a polar bear neonate (Ursus maritimus), and 2 additional bear fetuses (species unknown). The Hyaenidae were represented by a striped hyaena neonate (Hyaena hyaena). In each species, the foramen ovale, when viewed from the terminal part of the caudal vena cava, had the appearance of a short tunnel. A thin fold of tissue, the developed remains of the embryonic septum primum, extended from the distal end of the caudal vena cava for a variable distance into the lumen of the left atrium and contributed towards the 'tunnel' appearance in all specimens. It constituted a large proportion of the tube, and its distal end was straight-edged. There was fibrous material underlying the endothelium of the flap, the apparent morphology of which suggested that it comprised cardiac muscle.(ABSTRACT TRUNCATED AT 250 WORDS)
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ISSN (down) 0021-8782 ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 269 Serial 632
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Author Kleinman, M.S.; Garman, R.H.
Title An endoscopic approach to a snow leopard Type Journal Article
Year 1978 Publication Gastroenterology Abbreviated Journal
Volume 74 Issue 6 Pages 1348
Keywords Animal; Bezoars; veterinary; Carnivora; Cats; Esophagoscopy; Male; browse; 370
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ISSN (down) 0016-5085 ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 47 Serial 536
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Author Subbotin, A.E.; Istomov, S.V.
Title The population status of snow leopards Uncia uncia (Felidae, Carnivora) in the western Sayan Mountain Ridge Type Journal Article
Year 2009 Publication Doklady Biologicl Sciences Abbreviated Journal
Volume 425 Issue Pages 183-186
Keywords population; status; snow; snow leopards; snow leopard; snow-leopards; snow-leopard; leopards; leopard; uncia; Uncia uncia; Uncia-uncia; Felidae; Carnivora; Sayan; mountain; Russian; Test; species; cat; Russia; area; range; Data; study; activity; activities; behavior; habitats; habitat; humans; Human; number; description; Animal; structure
Abstract The snow leopard (Uncia uncial Schreber, 1776) is the most poorly studied species of the cat family in the world and, in particular, in Russia, where the northern periphery of the species area (no more than 3% of it) is located in the Altai-Hangai-Sayan range [1]. It is generally known that the existing data on the Russian part of the snow leopard population have never been a result of targeted studies; at best, they have been based on recording the traces of the snow leopard vital activity [2]. This is explained by the snow leopard's elusive behavior, inaccessibility of its habitats for humans, and its naturally small total numbers in the entire species area. All published data on the population status of the snow leopard in Russia, from the first descriptions of the species [3-6] to the latest studies [7, 8] are subjective, often speculative, and are not confirmed by

quantitative estimates. It is obvious, however, that every accurate observation of this animal is of particular interest [9]. The purpose of our study was to determine the structure and size of the population group presumably inhabiting the Western Sayan mountain ridge at the northern boundary of the species area
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Publisher Pleiades Publishing, Ltd. Place of Publication Editor
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ISSN (down) 0012-4966 ISBN Medium
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Notes Original Russian test published in Doklady Akademii Nauk, Vol. 425, No.6, pp.846-849. Approved no
Call Number SLN @ rana @ 1005 Serial 941
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Author Chandra, S.; Laughlin, D.C.
Title Virus-like particles in cystic mammary adenoma of a snow leopard Type Journal Article
Year 1975 Publication Cancer Res Abbreviated Journal
Volume 35 Issue 11 Pt 1 Pages 3069-3074
Keywords Adenoma pathology veterinary; Animal; Animals; zoo; Carnivora; Cytoplasmic Granules; Endoplasmic Reticulum: ultrastructure; Inclusion Bodies; Mammae: pathology; Neoplasms: pathology: veterinary; neoplasms; pathology; mammae; inclusion; bodies; ultrastructure; reticulum; endoplasmic; granules; cytoplasmic; adenoma; veterinary; browse; 380
Abstract Virus-like particles were observed in the giant cells of a mammary adenoma of a snow leopard kept in captivity. Particles that measured 115 to 125 nm in diameter budded from the lamella of endoplasmic reticulum and were studded on their inner surfaces with dense granules (approximately 12 nm) that gave them their unique ultrastructural morphology. Such particles were not observed extracellularly. Type B or type C particles were not seen in the tumor tissue.
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ISSN (down) 0008-5472 ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 27 Serial 212
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Author Johnston, L.A.; Donoghue, A.M.; O'Brien, S.J.; Wildt, D.E.
Title Rescue and maturation in vitro of follicular oocytes collected from nondomestic felid species Type Journal Article
Year 1991 Publication Biol Reprod Abbreviated Journal
Volume 45 Issue 6 Pages 898-906
Keywords Animal; Carnivora; anatomy; histology; physiology; Cells; Cultured; Female; Fertilization; Vitro; inVitro; Male; Oocytes; cytology; growth; development; ovarian; Follicle; Spermatozoa; Support; Non-U.S.Gov't; U.S.Gov't; P.H.S.; browse; non; us; gov't; government; 230
Abstract The potential for rescuing immature oocytes from the ovaries of females of rare felid species which die or undergo medical ovariohysterectomy was evaluated. Ovaries were recovered from 13 species representing 35 individuals in good-to-poor health. Although the majority of females were 10 yr of age or older and in fair-to-poor health, a total of 846 oocytes were recovered of which 608 (71.9%) were classified as fair-to- excellent quality. One hundred of these oocytes were used for initial maturation classification and as parthogenetic controls. Overall, of the 508 fair-to-excellent quality oocytes placed in culture, 164 (32.3%) matured to metaphase II in vitro. For species in which 3 or more individuals yielded oocytes, mean oocyte maturation rates were as follows: 36.2%, tiger; 27.9% leopard; and 8.3%, cheetah. In vitro insemination of oocytes resulted in fertilization (2 polar bodies, 2 pronuclei, or cleavage) rates of 9.1% to 28.6% (leopard) using homologous fresh spermatozoa and 4.0% (lion) to 40.0% (puma) using homologous frozen-thawed spermatozoa. Inseminations using heterologous (domestic cat) spermatozoa also resulted in fertilized oocytes in the tiger, leopard, snow leopard, puma, serval, and Geoffroy's cat (range in fertilization rate, 5.0% for leopard to 46.2% for puma). Cleaved embryos resulted from the insemination of leopard oocytes with homologous sperm (n = 1 embryo) and puma oocytes with domestic cat sperm (n = 3 embryos). These results demonstrate that immature ovarian oocytes from rare felid species can be stimulated to mature in vitro despite an excision-to-culture interval as long as 36 h.(ABSTRACT TRUNCATED AT 250 WORDS)
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ISSN (down) 0006-3363 ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 172 Serial 503
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Author Brown, J.L.; Wasser, S.K.; Wildt, D.E.; Graham, L.H.
Title Comparative Aspects of Steroid Hormone Metabolism and Ovarian Activity in Felids, Measured Noninvasively in Feces Type Journal Article
Year 1994 Publication Biol Reprod Abbreviated Journal
Volume 51 Issue 4 Pages 776-786
Keywords Animal; Carbon; Radioisotopes; Carnivora; Cats; Chromatography; High; Pressure; Liquid; Comparative Study; Estradiol; metabolism; Estrone; feces; chemistry; Female; Ovary; physiology; Pregnancy; Progesterone; Pseudopregnancy; Support; Non-U.S.Gov't; browse; non; government; gov't; us; 170
Abstract Noninvasive fecal assays were used to study steroid metabolism and ovarian activity in several felid species. Using the domestic cat (Felis catus) as model, the excretory products of injected [14C]estradiol (E2) and [14C]progesterone (P4) were determined. Within 2 days, 97.0 +/- 0.6% and 96.7 +/- 0.5% of recovered E2 and P4 radioactivity, respectively, was found in feces. E2 was excreted as unconjugated estradiol and estrone (40%) and as a non-enzyme- hydrolyzable conjugate (60%). P4 was excreted primarily as non-enzyme- hydrolyzable, conjugated metabolites (78%) and as unconjugated pregnenolone epimers. A simple method for extracting fecal steroid metabolites optimized extraction efficiencies of the E2 and P4 excretion products (90.1 +/- 0.8% and 87.2 +/- 1.4%, respectively). Analysis of HPLC fractions of extracted fecal samples from the radiolabel-injected domestic cats revealed that E2 immunoreactivity coincided primarily with the unconjugated metabolized [14C]E2 peak, whereas progestogen immunoreactivity coincided with a single conjugated epimer and multiple unconjugated pregnenolone epimers. After HPLC separation, similar immunoreactive E2 and P4 metabolite profiles were observed in the leopard cat (F. bengalensis), cheetah (Acinonyx jubatus), clouded leopard (Neofelis nebulosa), and snow leopard (Panthera uncia). Longitudinal analyses demonstrated that changes in fecal E2 and P4 metabolite concentrations reflected natural or artificially induced ovarian activity. For example, severalfold increases in E2 excretion were associated with overt estrus or exogenous gonadotropin treatment, and elevated fecal P4 metabolite concentrations occurred during pregnant and nonpregnant (pseudopregnant) luteal phases. Although overall concentrations were similar, the duration of elevated fecal P4 metabolites during pseudopregnancy was approximately half that observed during pregnancy. In summary, steroid metabolism mechanisms appear to be conserved among these physically diverse, taxonomically related species. Results indicate that this hormone-monitoring approach will be extremely useful for elucidating the hormonal regulatory mechanism associated with the reproductive cycle, pregnancy, and parturition of intractable and endangered felid species.
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ISSN (down) 0006-3363 ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 251 Serial 198
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Author Karesh, W.B.; Kunz, L.L.
Title Bilateral testicular seminoma in a snow leopard Type Journal Article
Year 1986 Publication J Am Vet Med Assoc Abbreviated Journal
Volume 189 Issue 9 Pages 1201
Keywords Animal; Carnivora; Case Report; Dysgerminoma; pathology; veterinary; Male; Testicular; neoplasms; Testis; browse; 300
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ISSN (down) 0003-1488 ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 98 Serial 514
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Author Paul, H.A.; Bargar, W.L.; Leininger, R.
Title Total hip replacement in a snow leopard Type Journal Article
Year 1985 Publication J Am Vet Med Assoc Abbreviated Journal
Volume 187 Issue 11 Pages 1262-1263
Keywords Animal; Carnivora; surgery; Case; Report; Hip; Dislocation; veterinary; Prosthesis; Male; browse; 310
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ISSN (down) 0003-1488 ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 82 Serial 760
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Author Mainka, S.A.
Title Bilateral separation of the olecranon and proximal epiphysis from the ulnar diaphysis in a snow leopard cub Type Journal Article
Year 1986 Publication J Am Vet Med Assoc Abbreviated Journal
Volume 189 Issue 9 Pages 1204-1205
Keywords Animal; Carnivora; injuries; Case-Report; Epiphyses; Forelimb; Male; Ulna; browse; 290
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ISSN (down) 0003-1488 ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 97 Serial 636
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