Abstract: Large carnivores are of vital importance to the stability and integrity of most ecosystems, but recent declines in free-ranging populations have highlighted the potentially devastating effect of infectious diseases on their conservation. We reviewed the literature on infectious diseases of 34 large (maximum body mass of adults >20 kg) terrestrial carnivore species, 18 of which are considered to be threatened in the wild, and examined reports of antibody prevalence (seroprevalence) and cases of infection, mortality and population decline. Of 52 diseases examined, 44% were viral, 31% bacterial and the remainder were protozoal or fungal. Many infections were endemic in carnivores and/or infected multiple taxonomic families, with the majority probably occurring via inhalation or ingestion. Most disease studies consisted of serological surveys for disease antibodies, and antibody detection tended to be widespread implying that exposure to micro-organisms was common. Seroprevalence was higher in tropical than temperate areas, and marginally higher for infections known to occur in multiple carnivore groups. Confirmation of active infection via micro-organism recovery was less common for ursids than other taxonomic groups. Published descriptions of disease-induced population decline or extinction were rare, and most outbreaks were allegedly the result of direct transmission of rabies or canine distemper virus (CDV) from abundant carnivore species to less-common large carnivores. We conclude that the threat of disease epidemics in large carnivores may be serious if otherwise lethal infections are endemic in reservoir hosts and transmitted horizontally among taxa. To prevent or mitigate future population declines, research efforts should be aimed at identifying both the diseases of potential importance to large carnivores and the ecological conditions associated with their spread and severity.

Abstract: Totally in Uzbekistan inhabited about 40 game species, but many of them became rare (Mellivora capensis indica, Lutra lutra seistanica, Hyaena hyaena, Felis pardus ciscaucasicus, Felis uncia, Felis ¤…a…c…l michaelis, F.manul ferrugineus, Cervus elaphus bactrianus, ¥…da… falconeri heptneri, Ovis orientalis bochariensis, I. about severtsovi, About ammon k…a†1ini), from fauna of region have disappeared Cuon alpinus hesperius, D…nthera tigris virgata, Acion¢o jubatus, Cervus elaphus sibiricus, Equus h†mionus, E. dazewalskii, Camelus bactrianus. For protection of valuable species of animals in Uzbekistan 6 nature reserves and 6 zakazniks were established.

Abstract: Phaeohyphomycosis caused by Cladophialophora bantiana was diagnosed in a 5-month-old snow leopard with spastic paralysis of the hind legs and inability to defaecate or urinate. At post-mortem examination, a greenish soft mass resembling an abscess was found on one side of the epidural space at the fourth lumbar vertebral body. Histological examination revealed a purulent meningitis with myelomalacia. Dematiaceous fungal hyphae, present within the inflammatory infiltrate, were identified as C. bantiana by culture and sequence analysis of the 18S ribosomal RNA gene. This neurotropic fungus rarely affects organs other than the brain in human beings and cats, and has been reported only occasionally in Europe. The case described suggests that phaeohyphomycosis due to C. bantiana infection may be recognized more frequently in the future and the possible involvement of organs other than the brain should be borne in mind.

Abstract: Status: rare (Category III). Distribution: Tien Shan mountains, Tarbagatai, Saur and Altai mountains. Total number in Kazakhstan does not exceed 200 individuals. The main threats are poaching and reduction number of preys. In Almaty Zoo captive breeding was successful in 1976 and 1985. Snow leopard is protected in Aksu Jabagly, Almaty and Markakol nature reserves. To ensure the survival of the species it is necessary to establish a reserve in Dzhungar mountains and to improve protection in existing nature reserves.