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Author Trepanier, L.A.; Cribb, A.E.; Spielberg, S.P.; Ray, K.
Title Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene Type Journal Article
Year 1998 Publication Pharmacogenetics Abbreviated Journal
Volume 8 Issue 2 Pages (down) 169-179
Keywords Acetylation; Amino; Acid; Sequence; Animal; Arylamine; N-Acetyltransferase; metabolism; Base; Blotting; Southern; Carnivora; genetics; Cats; Cytosol; enzymology; Dna; Human; Isoenzymes; Liver; Molecular; Data; Polymerase; Chain; Reaction; Rabbits; Homology; Nucleic Acid; Substrate; Specificity; Support; U.S.Gov't; P.H.S.; browse; nucleic; us; government; 130
Abstract The purpose of this study was to determine the molecular basis for a relative deficiency in the cat of cytosolic arylamine N- acetyltransferase (NAT), an enzyme family that is important in the metabolism of xenobiotics and that normally consists of at least two related enzymes, NAT1 and NAT2. N-acetyltransferase in feline liver showed high affinity (mean Km = 2.1 microM) for p-aminobenzoic acid, an NAT1 selective substrate in humans and rabbits, but showed a very poor affinity (mean Km > 10 mM) for sulfamethazine, an NAT2 selective substrate in humans and rabbits. Immunoreactive N-acetyltransferase was detected in feline liver, bladder and colon using an NAT1-specific antipeptide antibody, but was not detected in any tissues using an NAT2- specific antibody. Southern blot analysis of genomic DNA demonstrated a single band in domestic cats using each of six restriction digests; single bands were also found on Southern blot analysis of six wild felids. The deduced amino acid sequence of the central portion of feline N-acetyltransferase, obtained by polymerase chain reaction amplification in both domestic cats and seven wild felids (lion, tiger, lynx, snow leopard, bobcat, Asian leopard cat and cheetah), contained three residues, Phe125, Arg127, and Tyr129, which determine NAT1-like substrate specificity in humans. These results support the conclusion that cytosolic arylamine N-acetylation activity is low in the cat because of the presence of a single N-acetyltransferase that has substrate specificity, immunogenicity and sequence characteristics similar to human NAT1, and that the unusual presence of only a single N- acetyltransferase gene appears to be a family wide trait shared by other felids.
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Language Summary Language Original Title
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ISSN 0960-314x ISBN Medium
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Notes Document Type: eng Approved no
Call Number SLN @ rana @ 345 Serial 968
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Author Koshkarev E.P.
Title Key areas of snow leopard's habitat as main conservation objects Type Miscellaneous
Year 1990 Publication Abbreviated Journal
Volume Part. 1. Issue Pages (down) 97-98
Keywords Kazakhstan; Southern Siberia; Central Asia; Talass ridge; Chatkal ridge; Zeravshan ridge; Hissar ridge; species range; key sites; snow leopard; nature reserves.; 7260; Russian
Abstract The most vulnerable key areas within the snow leopard habitat are East Kazakhstan (an area of 48,000 square km) with no protected areas network established, and South Siberia (131,000 square km), where snow leopard is protected in three nature reserves. These areas are distant from main part of the habitat, isolated and have more extreme conditions. In Central Asia's key area (213,000 square km) linked to a main Chinese-Afghani part of the habitat, snow leopard was found in 11 nature reserves and two national parks. For reliable protection of this species it would be expedient to strengthen the role of the mountain nature reserves by means of extension and amalgamation of the areas, and other measures.
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Notes Full text available in Russian Journal Title: Environmental problems of wildlife protection. Approved no
Call Number SLN @ rana @ 704 Serial 560
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Author Farrington, J.
Title A Report on Protected Areas, Biodiversity, and Conservation in the Kyrgyzstan Tian Shan with Brief Notes on the Kyrgyzstan Pamir-Alai and the Tian Shan Mountains of Kazakhstan, Uzbekistan, and China Type Book Whole
Year 2005 Publication Abbreviated Journal
Volume Issue Pages (down) 1-276
Keywords Report; protected; protected areas; protected area; protected-areas; protected-area; areas; area; biodiversity; conservation; Kyrgyzstan; Tian; Tian-Shan; shan; Pamir-Alai; mountains; mountain; Kazakhstan; Uzbekistan; China; environmental; study; former; soviet; central; Central Asia; asia; land; Forest; snow; snow leopards; snow leopard; snow-leopards; snow-leopard; leopards; leopard; Chinese; range; republic; wildlife; International; research; land-use; land use; recent; inner; project; ecological; Middle; Middle Asia; Organization; awareness; region; preserve; species; ecosystems; ecosystem; potential; community; Biodiversity conservation; Xinjiang; information; Kyrgyz; Kyrgyz-Republic; protection; flora; fauna; mammals; birds; reptiles; amphibians; endemic; plants; plant; history; Southern; survey; protect; river; heart
Abstract Kyrgyzstan is a land of towering mountains, glaciers, rushing streams, wildflowercovered meadows, forests, snow leopards, soaring eagles, and yurt-dwelling nomads. The entire nation lies astride the Tian Shan1, Chinese for “Heavenly Mountains”, one of the world's highest mountain ranges, which is 7439 m (24,400 ft) in elevation at its highest point. The nation is the second smallest of the former Soviet Central Asian republics. In

spite of Kyrgyzstan's diverse wildlife and stunning natural beauty, the nation remains little known, and, as yet, still on the frontier of international conservation efforts. The following report is the product of 12 months of research into the state of conservation and land-use in Kyrgyzstan. This effort was funded by the Fulbright Commission of the U.S. State Department, and represents the most recent findings of the author's personal environmental journey through Inner Asia, which began in 1999. When I first started my preliminary research for this project, I was extremely surprised to learn that, even though the Tian Shan Range has tremendous ecological significance for conservation efforts in middle Asia, there wasn't a single major international conservation organization with an office in the former Soviet Central Asian republics. Even more surprising was how little awareness there is of conservation issues in the Tian Shan region amongst conservation workers in neighboring areas who are attempting to preserve similar species assemblages and ecosystems to those found in the Tian Shan. Given this lack of awareness, and the great potential for the international community to make a positive contribution towards improving the current state of biodiversity conservation in Kyrgyzstan and Central Asia, I have summarized my findings on protected areas and conservation in Kyrgyzstan and the Tian Shan of Kazakhstan, Uzbekistan, and Xinjiang in the chapters below. The report begins with some brief background information on geography and society in the Kyrgyz Republic, followed by an overview of biodiversity and the state of conservation in the nation, which at the present time closely parallels the state of conservation in the other former Soviet Central Asian republics. Part IV of the report provides a catalog of all major protected areas in Kyrgyzstan and the other Tian Shan nations, followed by a list of sites in Kyrgyzstan that are as yet unprotected but merit protection. In the appendices the reader will find fairly comprehensive species lists of flora and fauna found in the Kyrgyz Republic, including lists of mammals, birds, fish, reptiles, amphibians, trees and shrubs, wildflowers, and endemic plants. In addition, a

draft paper on the history and current practice of pastoral nomadism in Kyrgyzstan has been included in Appendix A. While the research emphasis for this study was on eastern Kyrgyzstan, over the course of the study the author did have the opportunity to make brief journeys to southern Kyrgyzstan, Uzbekistan, Kazakhstan, and Xinjiang. While falling short of being a definitive survey of protected areas of the Tian Shan, the informational review which

follows is the first attempt at bringing the details of conservation efforts throughout the entire Tian Shan Range together in one place. It is hoped that this summary of biodiversity and conservation in the Tian Shan will generate interest in the region amongst conservationists, and help increase efforts to protect this surprisingly unknown range that forms an island of meadows, rivers, lakes, and forests in the arid heart of Asia.
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Corporate Author Thesis Ph.D. thesis
Publisher Place of Publication Kyrgyzstan Editor
Language Summary Language Original Title
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Notes Fulbright Fellow – Environmental Studies, Kyrgyzstan, Former Soviet Central Asia 2003-2004 Approved no
Call Number SLN @ rana @ 1060 Serial 269
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Author The Snow Leopard Conservancy
Title Visitor Satisfaction and Opportunity Survey, Manang, Nepal: Market Opportunities for Linking Community-Based Ecotourism with the Conservation of Snow Leopards in the Annpurna Conservation Area. Report prepared for WWF-Nepal Programme Type Report
Year 2002 Publication Abbreviated Journal
Volume SLC Field Document Series No 3 Issue Pages (down) 1-18
Keywords survey; Manang; Nepal; linking; community-based; ecotourism; conservation; snow; snow leopards; snow leopard; snow-leopards; snow-leopard; leopards; leopard; area; Report; valley; trekking; Southern; annapurna; Tibet; landscape; mountain; Culture; region; habitat; endangered; High; density; densities; abundance; blue; blue sheep; blue-sheep; sheep; primary; large; prey; prey species; prey-species; species; Himalayan; mountains; tibetan; tibetan plateau; tibetan-plateau; plateau
Abstract For the past two decades, the Manang or Nyeshang Valley has become one of the most popular

trekking routes in Nepal, attracting over 15,000 trekkers annually (Ale, 2001). The 21-day

circular trek takes the visitor from the lush southern slopes of the Annapurna massif around to

its dry northern slopes more reminiscent of Tibet, through a landscape of spectacular mountain

scenes, interesting villages and diverse cultures. The Manang region also offers prime habitat

for the endangered snow leopard, supporting an estimated 4.8 – 6.7 snow leopards per 100 sq.

km (Oli 1992). This high density has been attributed to the abundance of blue sheep, the snow

leopard's primary large prey species across the Himalayan Mountains and Tibetan Plateau.
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Notes Approved no
Call Number SLN @ rana @ 1021 Serial 961
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Author Maheshwari, A., Niraj, S. K
Title Monitoring illegal trade in snow leopards: 2003e2014 Type Journal Article
Year 2018 Publication Elsevier Abbreviated Journal
Volume Issue Pages (down) 1 -6
Keywords Snow leopard, Illegal trade, Central and southern Asia, Conservation
Abstract Illegal trade in snow leopards (Panthera uncia) has been identified as one of the major

threats to long-term survival of the species in the wild. To quantify severity of the threats

to dwindling snow leopard population, we examined market and questionnaire surveys,

and information from the published and unpublished literature on illegal trade and

poaching of snow leopards.We collected information from 11 of the 12 snow leopard range

counties in central and southern Asia, barring Kazakhstan, and reported 439 snow leopards

(88 records) in illegal trade during 2003e2014, which represents a loss of approximately

8.4%e10.9% snow leopard population (assuming mid-point population of 5240 to

minimum population of 4000 individuals) in a period of 12 years. Our data suggested a 61%

decadal increase in snow leopard trade during 2003e2012 compared with 1993e2002,

while taking the note of significant strengthening of wildlife enforcement and crime

control network in the decades of 2000s and 2010s. We found 50% prosecution rate of

snow leopard crimes resulting in only 20% conviction rate globally. Many limitations e.g.,

secretive nature of illegal trade, ill developed enforcement mechanism, poor and passive

documentation of snow leopards' seizures, restricted us to reflect actual trend of snow

leopards' illegal trade. Even on a conservative scale the present situation is alarming and

may detrimental to snow leopard conservation. We propose an effective networking of

enforcement efforts and coordination among the law enforcement agencies, efficient

collection of data and data management, and sharing of intelligence in snow leopard range

countries, could be useful in curbing illegal trade in snow leopards in central and southern

Asia.
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Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
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Area Expedition Conference
Notes Approved no
Call Number SLN @ rakhee @ Serial 1466
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