Abstract: Caspian tiger, cheetah, moral have disappeared from the region's fauna. Species such as hyena, leopard, manul are endangered, honey badger and caracal available only on the south of Karakalpakstan, lynx, snow leopard and saiga are rare species. The implemented protection measures helped Iranian otter, Bukhara red deer, marchor, and Severtsev's sheep escape a total extermination. To preserve many valuable animals in Uzbekistan small investments in their habitats improvement are required. Nature reserves and preserves occupy a total area of more than 220,000 ha in the country. All rare species of Central Asia's fauna are under protection of the state.