Abstract: An attempt of analyzing the role of Uzbekistan' nature reserves in conservation of gene pool of the rare and endangered terrene vertebrate fauna is done. Of 21 rare vertebrate species, 11 mammal species, eight nesting bird species and two reptile species were detected to inhabit seven nature reserves. This makes up 36.2 percent within the total number of species included in the Red Data Book of the Uzbek SSR or 3.7 percent of the country's fauna. Single snow leopards were found in the Chatkal and Hissar nature reserves. Data of the species inhabiting the Zaamin nature reserve needs to be verified.