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Author |
Trepanier, L.A.; Cribb, A.E.; Spielberg, S.P.; Ray, K. |
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Title |
Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene |
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Journal Article |
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1998 |
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Pharmacogenetics |
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8 |
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2 |
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169-179 |
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Acetylation; Amino; Acid; Sequence; Animal; Arylamine; N-Acetyltransferase; metabolism; Base; Blotting; Southern; Carnivora; genetics; Cats; Cytosol; enzymology; Dna; Human; Isoenzymes; Liver; Molecular; Data; Polymerase; Chain; Reaction; Rabbits; Homology; Nucleic Acid; Substrate; Specificity; Support; U.S.Gov't; P.H.S.; browse; nucleic; us; government; 130 |
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The purpose of this study was to determine the molecular basis for a relative deficiency in the cat of cytosolic arylamine N- acetyltransferase (NAT), an enzyme family that is important in the metabolism of xenobiotics and that normally consists of at least two related enzymes, NAT1 and NAT2. N-acetyltransferase in feline liver showed high affinity (mean Km = 2.1 microM) for p-aminobenzoic acid, an NAT1 selective substrate in humans and rabbits, but showed a very poor affinity (mean Km > 10 mM) for sulfamethazine, an NAT2 selective substrate in humans and rabbits. Immunoreactive N-acetyltransferase was detected in feline liver, bladder and colon using an NAT1-specific antipeptide antibody, but was not detected in any tissues using an NAT2- specific antibody. Southern blot analysis of genomic DNA demonstrated a single band in domestic cats using each of six restriction digests; single bands were also found on Southern blot analysis of six wild felids. The deduced amino acid sequence of the central portion of feline N-acetyltransferase, obtained by polymerase chain reaction amplification in both domestic cats and seven wild felids (lion, tiger, lynx, snow leopard, bobcat, Asian leopard cat and cheetah), contained three residues, Phe125, Arg127, and Tyr129, which determine NAT1-like substrate specificity in humans. These results support the conclusion that cytosolic arylamine N-acetylation activity is low in the cat because of the presence of a single N-acetyltransferase that has substrate specificity, immunogenicity and sequence characteristics similar to human NAT1, and that the unusual presence of only a single N- acetyltransferase gene appears to be a family wide trait shared by other felids. |
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0960-314x |
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Document Type: eng |
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SLN @ rana @ 345 |
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968 |
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Author |
Trivedi, P. |
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Title |
Project Snow Leopard: Participatory conservation model for the Indian Himalaya |
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Magazine Article |
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2009 |
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Mountain Forum Bulletin |
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Ix |
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2 |
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52-54 |
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assessment; biodiversity; biodiversity assessment; conservation; global; Himalaya; Icimod; indian; links; mountain; network; participatory; project; Project-snow-leopard; project snow leopard; projects; research; resource; snow-leopard; snow leopard; Support |
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Mountain Forum |
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1815-2139 |
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More details at: www.conservation.in or www.ncf-india.org and www.wii.gov.in Newsletter published biannually by Mountain Forum: www.mtnforum.org. Editorial Team: Marianne Heredge, Ujol Sherchan, Frans Neuman,
Laura Keenan, Sunita Chaudhary, Suman Jaiswal. This newlstter edition is a joint product of the Mountain Forum, GMBA and MRI with support from ICIMOD, and brings together contributions from the three networks and partners. It also has a section on links to interesting organisations, resources and projects on Mountain Biodiversity. Published by the Mountain Forum Secretariat in collaboration with the respective Nodes in
Africa, Asia-Pacific, Europe, Latin America and North America and with the assistance of the Mountain Research Initiative (MRI) and the Global Mountain Biodiversity Assessment (GMBA). |
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SLN @ rana @ 1054 |
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969 |
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Tserendeleg, J. |
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Title |
On Protection and Survey of Snow Leopards in Mongolia |
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Conference Article |
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1994 |
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43-46 |
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Mongolia; transects; survey; habitat; conservation; distribution; irbis; herders; Altay; Altai; predator; prey; ibex; argali; hunting; pelts; skins; furs; coats; killing; behavior; activity; scrapes; feces; scat; sprays; mating; breeding; gestation; Pregnancy; browse; Macne; blood-sucking; poison; Blood; sucking; 2890 |
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Islt |
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Usa |
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J.L.Fox; D.Jizeng |
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Full text at URLTitle, Monographic: Seventh International Snow Leopard SymposiumPlace of Meeting: ChinaDate of Copyright: 1994 |
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SLN @ rana @ 259 |
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970 |
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Tserendeleg, J. |
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Title |
Status and Conservation of Snow Leopard in Mongolia |
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1997 |
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42-47 |
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Mongolia; Macne; Altai; conservation; status; distribution; herder; herders; livestock; gobi; argali; ibex; scrapes; hunters; marmot; predator; prey; parks; park; reserve; reserves; refuge; protected-area; browse; protected area; protected; 2510 |
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International Snow Leopard Trust |
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Lahore, Pakistan |
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R.Jackson; A.Ahmad |
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Full text at URLTitle, Monographic: Eighth International Snow Leopard SymposiumPlace of Meeting: Islamabad, PakistanDate of Copyright: 1997 |
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SLN @ rana @ 328 |
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971 |
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Author |
Tsherbakov B.V. |
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Title |
About rare and endangered mammal species in the East Kazakhstan region |
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Miscellaneous |
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1982 |
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203-204 |
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Kazakhstan; Eastern Kazakhstan province; distribution; number; rare species; snow leopard.; 8400; Russian |
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Given is data concerning numbers and distribution of yellow lemming on the Korjun cape and in the Karakas tract; dhole in the tundra zoneof the Azu-Tau ridge (South Alati) between Matabay and Urunkhaikoy, in the Salkanchok mountains; concering an encounter with snow leopard (March 25, 1981) in the upper river Bukhtarma near eastern extremity of the South Altai ridge, and argali in the mountain group Kalby-Baicha, the Taldy, Koktau, Monraka mountains (an area between Kusty and Kizil-Gain), near summit Shorbas. |
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Full text available in RussianJournal Title: Fauna of Kazakhstan and its conservation problems. |
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SLN @ rana @ 818 |
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972 |
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Author |
Tsherbina E.I. |
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Title |
Snow leopard or irbis |
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Miscellaneous |
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1970 |
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55-56 |
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Turkmenistan; snow leopard; distribution.; 8420; Russian |
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In the USSR, snow leopard is distributed in the mountains of Central Asia and South Siberia. A considerable number of snow leopards are met in the mountains of Tajikistan, Pamir, Tien Shan, Altai, and Tuva ASSR. Snow leopard is extremely rare in Turkmenistan. It is occasionally caught/shot in Kopet-Dag. |
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Full text available in RussianJournal Title: Commercial game species of Turkmenistan. |
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SLN @ rana @ 819 |
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973 |
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Author |
Turner, L. |
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Title |
Oklahoma City Zoo-Twenty Nine Snow Leopards |
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1980 |
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Int.Ped Book of Snow Leopards |
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2 |
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96-111 |
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zoos; captivity; husbandry; zoo; breeding; housing; browse; 3690 |
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Discusses breeding, housing, aquisition, history |
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SLN @ rana @ 66 |
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974 |
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Author |
Tursun, H.; Wenhu, Y.; Meng, X.H. |
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Title |
Great Exploitation of the West and the Basic Thoughts of the Great Development Strategy of Xinjiang |
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2000 |
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Arid Land Geography |
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23 |
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3 |
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193-198 |
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5410 |
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In Chinese. |
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SLN @ rana @ 525 |
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975 |
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Author |
Tursunov Kh. |
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The Ugam-Chatkal national park. The Chatkal state biosphere nature reserve |
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2003 |
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Uzbekistan; Ugam Chatkal national park; Chatkal nature reserve; flora; fauna; endangered species; snow leopard.; 8430; Russian |
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Established in 1990, the Ugam-Chatkal national park occupies an area of 668,350 ha and is the largest protected natural area in Uzbekistan. This area is famous for its rich species diversity. A number of rare and endangered plant and animal species, including among the others snow leopard, is found here. Being a core zone (strictly protected natural area), the Chatkal nature reserve is an integral part of the park. Snow leopard is periodically observed in the Tereksay river valley in the Maidantal area. |
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Full text available in RussianJournal Title: Ecologic problems of the West Tien Shan. |
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SLN @ rana @ 820 |
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976 |
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Uchitelskaya gazeta. |
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Title |
Return of snow leopard |
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Miscellaneous |
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1984 |
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Uzbekistan; Hissar ridge; Kyzylsu nature reserve; Miraki nature reserve; birds; mammals; snow leopard.; 8440; Russian |
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10 snow leopards have settled in western extremities of the Hissar ridge. Almost 25 years ago, disturbed by anthropogenic activity, this rarest fauna representative abandoned the area being threatened. In a habitat usual for this species have now been created the Kyzylsu and Miraki nature reserves and the species is now rendering the highlands inhabitable again. Wild boar, Turkestan lynx, long-tailed marmot, snow leopard and black vulture, a total of 200 animal and bird species, can be found now in this area. |
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January 3 1984 |
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Russian |
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Full text available in Russian Journal Title: Newspaper Uchitelskaya gazeta. |
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SLN @ rana @ 821 |
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977 |
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