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Trepanier, L.A.; Cribb, A.E.; Spielberg, S.P.; Ray, K. |
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Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene |
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1998 |
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Pharmacogenetics |
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8 |
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2 |
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169-179 |
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Acetylation; Amino; Acid; Sequence; Animal; Arylamine; N-Acetyltransferase; metabolism; Base; Blotting; Southern; Carnivora; genetics; Cats; Cytosol; enzymology; Dna; Human; Isoenzymes; Liver; Molecular; Data; Polymerase; Chain; Reaction; Rabbits; Homology; Nucleic Acid; Substrate; Specificity; Support; U.S.Gov't; P.H.S.; browse; nucleic; us; government; 130 |
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The purpose of this study was to determine the molecular basis for a relative deficiency in the cat of cytosolic arylamine N- acetyltransferase (NAT), an enzyme family that is important in the metabolism of xenobiotics and that normally consists of at least two related enzymes, NAT1 and NAT2. N-acetyltransferase in feline liver showed high affinity (mean Km = 2.1 microM) for p-aminobenzoic acid, an NAT1 selective substrate in humans and rabbits, but showed a very poor affinity (mean Km > 10 mM) for sulfamethazine, an NAT2 selective substrate in humans and rabbits. Immunoreactive N-acetyltransferase was detected in feline liver, bladder and colon using an NAT1-specific antipeptide antibody, but was not detected in any tissues using an NAT2- specific antibody. Southern blot analysis of genomic DNA demonstrated a single band in domestic cats using each of six restriction digests; single bands were also found on Southern blot analysis of six wild felids. The deduced amino acid sequence of the central portion of feline N-acetyltransferase, obtained by polymerase chain reaction amplification in both domestic cats and seven wild felids (lion, tiger, lynx, snow leopard, bobcat, Asian leopard cat and cheetah), contained three residues, Phe125, Arg127, and Tyr129, which determine NAT1-like substrate specificity in humans. These results support the conclusion that cytosolic arylamine N-acetylation activity is low in the cat because of the presence of a single N-acetyltransferase that has substrate specificity, immunogenicity and sequence characteristics similar to human NAT1, and that the unusual presence of only a single N- acetyltransferase gene appears to be a family wide trait shared by other felids. |
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0960-314x |
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Document Type: eng |
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SLN @ rana @ 345 |
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968 |
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Author |
Sunquist, F. |
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Title |
Where cats and herders mix. (snow leopards in Tibet and Mongolia) |
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Journal Article |
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Year |
1997 |
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International Wildlife |
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27 |
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1 |
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27-33 |
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Mongolia; Tibet; herder; livestock; snow-leopard; predator; prey; World-Wildlife-Foundation; habitat; reserve; park; refuge; Pakistan; China; herders; parks; protected-area; snow leopard; browse; Wwf; world wildlife foundation; 1110; snow; leopard; range; territory; central; Central Asia; asia; Animal; region; conservation; wildlife; foundation; border; sheep; Baltistan; enclosures; area; home; snow leopards; snow-leopards; leopards; countries; country; Feed; Cats; cat; mountain; peoples; people |
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The snow leopard inhabits a huge range of territory which encompasses some of Central Asia's most bleak and inhospitable terrains. The animal herders in these regions are desperately poor and yet they have agreed to cooperate with conservation groups in protecting the snow leopard. The World Wildlife Foundation has worked to create a refuge on the Pakistan-China border. Sheep herders near Askole, a village in the Baltistan region of northern Paksitan, drive their flocks past stone enclosures. The area is also home to snow leopards. With their natural prey dminished, leopards in 13 countries of central Asia occasionally feed on livestock, putting the cats on a collision course with mountain peoples. |
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COPYRIGHT 1997 National Wildlife Federation , Jan-Feb 1997 v27 n1 p26(8) Document Type: English |
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SLN @ rana @ 330 |
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950 |
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Macdonald, A.A.; Johnstone, M. |
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Comparative anatomy of the cardiac foramen ovale in cats (Felidae), dogs (Canidae), bears (Ursidae) and hyaenas (Hyaenidae) |
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1995 |
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J Anat |
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186 ( Pt 2) |
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235-243 |
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Animal; Newborn; Bears: anatomy & histology; Carnivora: anatomy & histology: embryology; Cats: anatomy & histology; Dogs: anatomy & histology; Heart Septum: anatomy & histology: embryology; Support,Non-U.S.Gov't; bear; anatomy; histology; Carnivora; embryology; Cats; cat; bears; Dog; Dogs; heart; septum; browse; non; gov't; us; government; 160 |
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The structure of the foramen ovale from 16 species representing 4 carnivore families, the Felidae, Canidae, Ursidae and Hyaenidae, was studied using the scanning electron microscope. The Felidae were represented by 9 domestic cat fetuses (Felis catus), 2 snow leopard neonates (Uncia uncia), an ocelot neonate (Leopardus pardalis), 2 lion neonates (Panthera leo), a panther neonate (Panthera pardus) and 3 tigers (Neofelis tigris), comprising 2 fetuses and a neonate. The Canidae were represented by a golden jackal neonate (Canis aureus), a newborn wolf (Canis lupus), 8 domestic dog fetuses (Canis familiaris), 3 red fox neonates (Vulpes vulpes) and a dhole neonate (Cuon alpinus). The Ursidae were represented by a brown bear neonate (Ursus arctos), a day-old grizzly bear cub (Ursus arctos horribilis), a polar bear neonate (Ursus maritimus), and 2 additional bear fetuses (species unknown). The Hyaenidae were represented by a striped hyaena neonate (Hyaena hyaena). In each species, the foramen ovale, when viewed from the terminal part of the caudal vena cava, had the appearance of a short tunnel. A thin fold of tissue, the developed remains of the embryonic septum primum, extended from the distal end of the caudal vena cava for a variable distance into the lumen of the left atrium and contributed towards the 'tunnel' appearance in all specimens. It constituted a large proportion of the tube, and its distal end was straight-edged. There was fibrous material underlying the endothelium of the flap, the apparent morphology of which suggested that it comprised cardiac muscle.(ABSTRACT TRUNCATED AT 250 WORDS) |
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0021-8782 |
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Document Type: eng |
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SLN @ rana @ 269 |
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632 |
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Kyes, R.; Chalise, M.K. |
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Assessing the Status of the Snow Leopard Population in Langtang National Park, Nepal |
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2005 |
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1-22 |
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status; snow; snow leopard; snow-leopard; leopard; population; Langtang; national; national park; National-park; park; Nepal; project; International; international snow leopard trust; International-Snow-Leopard-Trust; trust; program; biodiversity; research; study; Support; Islt; approach; Data; conservation; snow leopards; snow-leopards; leopards; survey; distribution; abundance; prey; prey species; prey-species; species; populations; programs; local; sign; pugmarks; scats; scat; primary; Himalayan; areas; area; Response; Pressure; domestic; domestic livestock; livestock; grazing |
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This project is part of an ongoing snow leopard study established in 2003 with support from the ISLT. The study involves a multifaceted approach designed to provide important baseline data on the status of the snow leopard population in Langtang National Park (LNP), Nepal and to generate long-term support and commitment to the conservation of snow leopards in the park. The specific aims include: 1) conducting a population survey of the snow leopards in LNP, focusing on distribution and abundance; 2) assessing the status of prey species populations in the park; and 3) providing educational outreach programs on snow leopard conservation for local school children (K-8) living in the park. During the 2004 study period, snow leopard signs were observed (including pugmarks and scats) although somewhat fewer than in 2003. Similarly, the average herd size of the snow leopards' primary prey species in LNP (the Himalayan thar) was a bit lower than in 2003. There is speculation that the thar populations and the snow leopards may be moving to more remotes areas of the park perhaps in response to increasing pressure from domestic livestock grazing. This possibility is being addressed during the 2005 study period. |
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Project funded by International Snow Leopard Trust Small Grants Program, 2004. University of Washington and Nepal Biodiversity Research Society/Tribhuvan University. |
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SLN @ rana @ 1072 |
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607 |
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