Abstract: Origination of fauna complexes in Uzbekistan from the Mustier period to present time is described. The remains of brown bear, cave hyena, wolf, fox, corsac, stone marten, badger, and snow leopard were found in cave Amankutan (western extremities of the Zaravshan ridge). Cattle breeding and farming has begun since mesolite; cave bear, Stenon horse, Pleistocene donkey, camel and aurochs dropped from the region's fauna, while marchor and striped hyena moved to the Hissar ridge, Babatag and Kugitang mountains from south; jackal, chaus, tiger, and Iranian otter settled along the river valleys. In the Neolith and Bronze Age cattle breeding and farming continued to develop, while hunting was less important. Mass hinting for animals in the time of Alexander the Great, Chingiz Khan, and Babur, the ruler of Fergana, is described. Mass extermination of kulan, goitered gazelle, saiga, and other game species also took place later more than 12,000 saigas were killed during one hunt at the end of 19th century in the Volga region. Animals also die from natural disasters the “djut”. Data concerning a current status of goitered gazelle, saiga, Bukhara deer, marchor, Severtsev's sheep, and urial is given.