Abstract: The 30 species of mammals are presented in Sary Chelek nature reserve, Kyrgyzstan. Comparison of status of mammal's diversity in Soviet period and present time is made. Number decrease for some mammals is noted. Number of snow leopard in Sary Chelek is 2 individuals, Turkestan lynx 3, wolf 10, bear 20, badger 20, fox 25, jackal 25, wild boar 100 individuals. Snow leopard included in national Red data Book and Global Red List.